enzyme activity nonhuman article 353 controlled study 310 priority journal 274 Animals 222 animal experiment 149 animal tissue 147 unclassified drug 137 animal cell 100 metabolism 99 male 98 mouse 95 protein expression 89 rat 88 Article 82 Mice 73 animal model 72 Rats 66 female 66 Male 64 enzyme inhibition 64 animal 63 Female 62 Animalia 60 Trypanosoma cruzi 50 oxidative stress 50 signal transduction 49 Humans 42 human 42