article controlled study enzyme activity nonhuman 241 priority journal 188 Animals 150 animal tissue 99 animal experiment 97 unclassified drug 78 male 72 rat 69 mouse 63 animal cell 62 protein expression 60 human 57 Male 56 Mice 56 Rats 53 Humans 52 Female 51 animal model 51 female 51 human cell 46 enzyme inhibition 45 Animalia 42 metabolism 36 signal transduction 36 Liver 30 enzyme activation 28 oxidative stress 27