Mode of action on Trypanosoma and Leishmania spp.

In this chapter, the most common molecular targets and mechanisms of action of anti-trypanosomatid drugs are described: Biosynthesis of sterols, trypano-thione pathway, purine salvage pathway, cysteine proteinases, trans-sialidase, metallocarboxypeptidases, tubulin, calcium homeostasis and pyrophosp...

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Detalles Bibliográficos
Autores principales: Lombardo, M.E., Batlle, A.
Formato: CHAP
Materias:
Anti-trypanosomatid drugs
Apoptosis
Drug targets
Heme
Oxidative stress
Proteinases
Sterol biosynthesis
Trans-sialidase
Trypanothione pathway
Tubulin
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_97833197_v_n_p223_Lombardo
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_97833197_v_n_p223_Lombardo
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spelling todo:paper_97833197_v_n_p223_Lombardo2023-10-03T16:45:03Z Mode of action on Trypanosoma and Leishmania spp. Lombardo, M.E. Batlle, A. Anti-trypanosomatid drugs Apoptosis Drug targets Heme Oxidative stress Proteinases Sterol biosynthesis Trans-sialidase Trypanothione pathway Tubulin In this chapter, the most common molecular targets and mechanisms of action of anti-trypanosomatid drugs are described: Biosynthesis of sterols, trypano-thione pathway, purine salvage pathway, cysteine proteinases, trans-sialidase, metallocarboxypeptidases, tubulin, calcium homeostasis and pyrophosphate metabolism, heme uptake and degradation, glycolytic pathway, DNA interaction, oxidative stress and apoptosis. Interaction of the sesquiterpene lactones with hemin, the induction of oxidative stress, the inhibition of enzymes as cruzipain and trypano-thione reductase, the apoptosis induction and the ability of this type of compounds to inhibit sterol biosynthesis will be also discussed. © Springer International Publishing AG, part of Springer Nature 2018. CHAP info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_97833197_v_n_p223_Lombardo
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Anti-trypanosomatid drugs
Apoptosis
Drug targets
Heme
Oxidative stress
Proteinases
Sterol biosynthesis
Trans-sialidase
Trypanothione pathway
Tubulin
spellingShingle Anti-trypanosomatid drugs
Apoptosis
Drug targets
Heme
Oxidative stress
Proteinases
Sterol biosynthesis
Trans-sialidase
Trypanothione pathway
Tubulin
Lombardo, M.E.
Batlle, A.
Mode of action on Trypanosoma and Leishmania spp.
topic_facet Anti-trypanosomatid drugs
Apoptosis
Drug targets
Heme
Oxidative stress
Proteinases
Sterol biosynthesis
Trans-sialidase
Trypanothione pathway
Tubulin
description In this chapter, the most common molecular targets and mechanisms of action of anti-trypanosomatid drugs are described: Biosynthesis of sterols, trypano-thione pathway, purine salvage pathway, cysteine proteinases, trans-sialidase, metallocarboxypeptidases, tubulin, calcium homeostasis and pyrophosphate metabolism, heme uptake and degradation, glycolytic pathway, DNA interaction, oxidative stress and apoptosis. Interaction of the sesquiterpene lactones with hemin, the induction of oxidative stress, the inhibition of enzymes as cruzipain and trypano-thione reductase, the apoptosis induction and the ability of this type of compounds to inhibit sterol biosynthesis will be also discussed. © Springer International Publishing AG, part of Springer Nature 2018.
format CHAP
author Lombardo, M.E.
Batlle, A.
author_facet Lombardo, M.E.
Batlle, A.
author_sort Lombardo, M.E.
title Mode of action on Trypanosoma and Leishmania spp.
title_short Mode of action on Trypanosoma and Leishmania spp.
title_full Mode of action on Trypanosoma and Leishmania spp.
title_fullStr Mode of action on Trypanosoma and Leishmania spp.
title_full_unstemmed Mode of action on Trypanosoma and Leishmania spp.
title_sort mode of action on trypanosoma and leishmania spp.
url http://hdl.handle.net/20.500.12110/paper_97833197_v_n_p223_Lombardo
work_keys_str_mv AT lombardome modeofactionontrypanosomaandleishmaniaspp
AT batllea modeofactionontrypanosomaandleishmaniaspp
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