Defining the fate and function of effector T cells through galectin-1-galectin-1 ligand-binding interactions: Implications in tumor immunity
Galectin-1 (Gal-1), a member of an ancient family of animal glycan-binding proteins, has been implicated in a variety of biological events. Interactions between Gal-1 and Gal-1 ligands on T cells are critically involved in regulating the nature and intensity of T-cell-mediated inflammation and antit...
Guardado en:
| Autores principales: | , |
|---|---|
| Formato: | CHAP |
| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_97814899_v_n_p347_Dimitroff |
| Aporte de: |
| id |
todo:paper_97814899_v_n_p347_Dimitroff |
|---|---|
| record_format |
dspace |
| spelling |
todo:paper_97814899_v_n_p347_Dimitroff2023-10-03T16:43:43Z Defining the fate and function of effector T cells through galectin-1-galectin-1 ligand-binding interactions: Implications in tumor immunity Dimitroff, C.J. Rabinovich, G.A. Adaptive immunity Galectin-1 Galectin-1 ligands Galectin-1 therapeutics Galectins Inflammation Tumor immunology Galectin-1 (Gal-1), a member of an ancient family of animal glycan-binding proteins, has been implicated in a variety of biological events. Interactions between Gal-1 and Gal-1 ligands on T cells are critically involved in regulating the nature and intensity of T-cell-mediated inflammation and antitumor immunity. Appropriately glycosylated T-cell-membrane glycoconjugates operationally defined as Gal-1 ligands bind Gal-1 and elicit downstream cellular activities that dampen effector T-cell function. Together, these biological constituents represent promising targets in the development of novel anti-inflammatory and antitumor immune therapies. Whether through characteristic elevations in tumor-derived Gal-1 or an imbalance in regulatory and Gal-1 ligand+ effector T-cell subsets during inflammation, the Gal-1-Gal-1 ligand-binding axis offers numerous cellular/tissue contexts to strategically interfere with Gal-1 efficacy. In this chapter, we will examine recent assessments of (1) Gal-1 expression and function in controlling both adaptive and antitumor T-cell immunity, (2) identity and function of T-cell Gal-1 ligands, and (3) targeting of the Gal-1-Gal-1 ligand axis to regulate inflammation or boost antitumor immune responses. These research disciplines collectively highlight the importance of understanding the identity and functional nature of Gal-1 and its ligands to strategically and safely manipulate the immune system to control immunopathologic conditions. © Springer Science+Business Media, LLC 2014. All rights are reserved. CHAP info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_97814899_v_n_p347_Dimitroff |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Adaptive immunity Galectin-1 Galectin-1 ligands Galectin-1 therapeutics Galectins Inflammation Tumor immunology |
| spellingShingle |
Adaptive immunity Galectin-1 Galectin-1 ligands Galectin-1 therapeutics Galectins Inflammation Tumor immunology Dimitroff, C.J. Rabinovich, G.A. Defining the fate and function of effector T cells through galectin-1-galectin-1 ligand-binding interactions: Implications in tumor immunity |
| topic_facet |
Adaptive immunity Galectin-1 Galectin-1 ligands Galectin-1 therapeutics Galectins Inflammation Tumor immunology |
| description |
Galectin-1 (Gal-1), a member of an ancient family of animal glycan-binding proteins, has been implicated in a variety of biological events. Interactions between Gal-1 and Gal-1 ligands on T cells are critically involved in regulating the nature and intensity of T-cell-mediated inflammation and antitumor immunity. Appropriately glycosylated T-cell-membrane glycoconjugates operationally defined as Gal-1 ligands bind Gal-1 and elicit downstream cellular activities that dampen effector T-cell function. Together, these biological constituents represent promising targets in the development of novel anti-inflammatory and antitumor immune therapies. Whether through characteristic elevations in tumor-derived Gal-1 or an imbalance in regulatory and Gal-1 ligand+ effector T-cell subsets during inflammation, the Gal-1-Gal-1 ligand-binding axis offers numerous cellular/tissue contexts to strategically interfere with Gal-1 efficacy. In this chapter, we will examine recent assessments of (1) Gal-1 expression and function in controlling both adaptive and antitumor T-cell immunity, (2) identity and function of T-cell Gal-1 ligands, and (3) targeting of the Gal-1-Gal-1 ligand axis to regulate inflammation or boost antitumor immune responses. These research disciplines collectively highlight the importance of understanding the identity and functional nature of Gal-1 and its ligands to strategically and safely manipulate the immune system to control immunopathologic conditions. © Springer Science+Business Media, LLC 2014. All rights are reserved. |
| format |
CHAP |
| author |
Dimitroff, C.J. Rabinovich, G.A. |
| author_facet |
Dimitroff, C.J. Rabinovich, G.A. |
| author_sort |
Dimitroff, C.J. |
| title |
Defining the fate and function of effector T cells through galectin-1-galectin-1 ligand-binding interactions: Implications in tumor immunity |
| title_short |
Defining the fate and function of effector T cells through galectin-1-galectin-1 ligand-binding interactions: Implications in tumor immunity |
| title_full |
Defining the fate and function of effector T cells through galectin-1-galectin-1 ligand-binding interactions: Implications in tumor immunity |
| title_fullStr |
Defining the fate and function of effector T cells through galectin-1-galectin-1 ligand-binding interactions: Implications in tumor immunity |
| title_full_unstemmed |
Defining the fate and function of effector T cells through galectin-1-galectin-1 ligand-binding interactions: Implications in tumor immunity |
| title_sort |
defining the fate and function of effector t cells through galectin-1-galectin-1 ligand-binding interactions: implications in tumor immunity |
| url |
http://hdl.handle.net/20.500.12110/paper_97814899_v_n_p347_Dimitroff |
| work_keys_str_mv |
AT dimitroffcj definingthefateandfunctionofeffectortcellsthroughgalectin1galectin1ligandbindinginteractionsimplicationsintumorimmunity AT rabinovichga definingthefateandfunctionofeffectortcellsthroughgalectin1galectin1ligandbindinginteractionsimplicationsintumorimmunity |
| _version_ |
1807321437939171328 |