Structure and electroporation of lipid bilayers: A molecular dynamics study

Pore formation in lipid bilayers subjected to a transverse electric field is studied by means of Molecular Dynamics simulations of 1,2-dipalmitoyl-sn- glycero-3-phosphatidylcholine (DOPC). The physical characteristics of the lipid membrane are crucial to understand the electroporation conditions. Fo...

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Autores principales:	Reigada, R., Fernandez, M.L.
Formato:	CONF
Materias:	Electroporation Lipid membranes Membrane electroporation Membrane permeabilization Membrane properties Molecular dynamics simulations Physical characteristics Pore formation Transverse electric field Dimethyl sulfoxide Dynamics Electric fields Membranes Molecular dynamics Organic solvents Lipid bilayers
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_97814244_v_n_p_Reigada
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_97814244_v_n_p_Reigada
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spelling	todo:paper_97814244_v_n_p_Reigada2023-10-03T16:43:13Z Structure and electroporation of lipid bilayers: A molecular dynamics study Reigada, R. Fernandez, M.L. Electroporation Lipid membranes Membrane electroporation Membrane permeabilization Membrane properties Molecular dynamics simulations Physical characteristics Pore formation Transverse electric field Dimethyl sulfoxide Dynamics Electric fields Membranes Molecular dynamics Organic solvents Lipid bilayers Pore formation in lipid bilayers subjected to a transverse electric field is studied by means of Molecular Dynamics simulations of 1,2-dipalmitoyl-sn- glycero-3-phosphatidylcholine (DOPC). The physical characteristics of the lipid membrane are crucial to understand the electroporation conditions. For example, addition of cholesterol (Chol) causes a substantial increment of membrane cohesion that results in an increase of the minimum electric field needed for membrane permeabilization. Instead, dimethyl sulfoxide (DMSO) is known to produce an opposite effect on membrane properties by increasing its fluidity and disorder that may open the possibility to facilitate the membrane electroporation process. © 2011 IEEE. CONF info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_97814244_v_n_p_Reigada
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Electroporation Lipid membranes Membrane electroporation Membrane permeabilization Membrane properties Molecular dynamics simulations Physical characteristics Pore formation Transverse electric field Dimethyl sulfoxide Dynamics Electric fields Membranes Molecular dynamics Organic solvents Lipid bilayers
spellingShingle	Electroporation Lipid membranes Membrane electroporation Membrane permeabilization Membrane properties Molecular dynamics simulations Physical characteristics Pore formation Transverse electric field Dimethyl sulfoxide Dynamics Electric fields Membranes Molecular dynamics Organic solvents Lipid bilayers Reigada, R. Fernandez, M.L. Structure and electroporation of lipid bilayers: A molecular dynamics study
topic_facet	Electroporation Lipid membranes Membrane electroporation Membrane permeabilization Membrane properties Molecular dynamics simulations Physical characteristics Pore formation Transverse electric field Dimethyl sulfoxide Dynamics Electric fields Membranes Molecular dynamics Organic solvents Lipid bilayers
description	Pore formation in lipid bilayers subjected to a transverse electric field is studied by means of Molecular Dynamics simulations of 1,2-dipalmitoyl-sn- glycero-3-phosphatidylcholine (DOPC). The physical characteristics of the lipid membrane are crucial to understand the electroporation conditions. For example, addition of cholesterol (Chol) causes a substantial increment of membrane cohesion that results in an increase of the minimum electric field needed for membrane permeabilization. Instead, dimethyl sulfoxide (DMSO) is known to produce an opposite effect on membrane properties by increasing its fluidity and disorder that may open the possibility to facilitate the membrane electroporation process. © 2011 IEEE.
format	CONF
author	Reigada, R. Fernandez, M.L.
author_facet	Reigada, R. Fernandez, M.L.
author_sort	Reigada, R.
title	Structure and electroporation of lipid bilayers: A molecular dynamics study
title_short	Structure and electroporation of lipid bilayers: A molecular dynamics study
title_full	Structure and electroporation of lipid bilayers: A molecular dynamics study
title_fullStr	Structure and electroporation of lipid bilayers: A molecular dynamics study
title_full_unstemmed	Structure and electroporation of lipid bilayers: A molecular dynamics study
title_sort	structure and electroporation of lipid bilayers: a molecular dynamics study
url	http://hdl.handle.net/20.500.12110/paper_97814244_v_n_p_Reigada
work_keys_str_mv	AT reigadar structureandelectroporationoflipidbilayersamoleculardynamicsstudy AT fernandezml structureandelectroporationoflipidbilayersamoleculardynamicsstudy
_version_	1782023942102319104

Structure and electroporation of lipid bilayers: A molecular dynamics study

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