How to Find an HNO Needle in a (Bio)-Chemical Haystack

Azanone (also called nitroxyl or simply HNO) is an intrinsic elusive molecule, with a proven history of chemically and biologically relevant reactivity. The chapter describes many HNO donors, potential HNO production reactions, and azanone potential biological effects. Azanone donors are based mainl...

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Detalles Bibliográficos
Autores principales:	Doctorovich, F., Bikiel, D.E., Pellegrino, J., Suárez, S.A., Martí, M.A.
Formato:	CHAP
Materias:	Azanone Biochemical reactions Chemical reactions HNO releasing agents Real-time detection method Therapeutic compounds Trapping method Amines Reaction kinetics Signal detection Real-time detection Releasing agent Trapping methods Chemical detection
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_97811187_v58_n_p145_Doctorovich
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_97811187_v58_n_p145_Doctorovich
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spelling	todo:paper_97811187_v58_n_p145_Doctorovich2023-10-03T16:42:55Z How to Find an HNO Needle in a (Bio)-Chemical Haystack Doctorovich, F. Bikiel, D.E. Pellegrino, J. Suárez, S.A. Martí, M.A. Azanone Biochemical reactions Chemical reactions HNO releasing agents Real-time detection method Therapeutic compounds Trapping method Amines Chemical reactions Reaction kinetics Signal detection Azanone Biochemical reactions Real-time detection Releasing agent Therapeutic compounds Trapping methods Chemical detection Azanone (also called nitroxyl or simply HNO) is an intrinsic elusive molecule, with a proven history of chemically and biologically relevant reactivity. The chapter describes many HNO donors, potential HNO production reactions, and azanone potential biological effects. Azanone donors are based mainly on hydroxylamine and its derivatives, NONOates, and C-nitroso compounds. HNO releasing agents have interesting perspectives as potential therapeutic compounds. However, more work, where HNO detections methods are critical, is needed to understand the chemical mechanisms underlying the observed physiological effects. Quantification of HNO is challenging because it is a very reactive species with a high rate for dimerization. Two different methodologies, trapping and real-time detection methods, have been explored in order to quantify HNO. The chapter reviews the recent advances in both types of azanone detection methods. © 2014 by John Wiley & Sons, Inc. All rights reserved. CHAP info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_97811187_v58_n_p145_Doctorovich
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Azanone Biochemical reactions Chemical reactions HNO releasing agents Real-time detection method Therapeutic compounds Trapping method Amines Chemical reactions Reaction kinetics Signal detection Azanone Biochemical reactions Real-time detection Releasing agent Therapeutic compounds Trapping methods Chemical detection
spellingShingle	Azanone Biochemical reactions Chemical reactions HNO releasing agents Real-time detection method Therapeutic compounds Trapping method Amines Chemical reactions Reaction kinetics Signal detection Azanone Biochemical reactions Real-time detection Releasing agent Therapeutic compounds Trapping methods Chemical detection Doctorovich, F. Bikiel, D.E. Pellegrino, J. Suárez, S.A. Martí, M.A. How to Find an HNO Needle in a (Bio)-Chemical Haystack
topic_facet	Azanone Biochemical reactions Chemical reactions HNO releasing agents Real-time detection method Therapeutic compounds Trapping method Amines Chemical reactions Reaction kinetics Signal detection Azanone Biochemical reactions Real-time detection Releasing agent Therapeutic compounds Trapping methods Chemical detection
description	Azanone (also called nitroxyl or simply HNO) is an intrinsic elusive molecule, with a proven history of chemically and biologically relevant reactivity. The chapter describes many HNO donors, potential HNO production reactions, and azanone potential biological effects. Azanone donors are based mainly on hydroxylamine and its derivatives, NONOates, and C-nitroso compounds. HNO releasing agents have interesting perspectives as potential therapeutic compounds. However, more work, where HNO detections methods are critical, is needed to understand the chemical mechanisms underlying the observed physiological effects. Quantification of HNO is challenging because it is a very reactive species with a high rate for dimerization. Two different methodologies, trapping and real-time detection methods, have been explored in order to quantify HNO. The chapter reviews the recent advances in both types of azanone detection methods. © 2014 by John Wiley & Sons, Inc. All rights reserved.
format	CHAP
author	Doctorovich, F. Bikiel, D.E. Pellegrino, J. Suárez, S.A. Martí, M.A.
author_facet	Doctorovich, F. Bikiel, D.E. Pellegrino, J. Suárez, S.A. Martí, M.A.
author_sort	Doctorovich, F.
title	How to Find an HNO Needle in a (Bio)-Chemical Haystack
title_short	How to Find an HNO Needle in a (Bio)-Chemical Haystack
title_full	How to Find an HNO Needle in a (Bio)-Chemical Haystack
title_fullStr	How to Find an HNO Needle in a (Bio)-Chemical Haystack
title_full_unstemmed	How to Find an HNO Needle in a (Bio)-Chemical Haystack
title_sort	how to find an hno needle in a (bio)-chemical haystack
url	http://hdl.handle.net/20.500.12110/paper_97811187_v58_n_p145_Doctorovich
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How to Find an HNO Needle in a (Bio)-Chemical Haystack

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