Cocaine Enhances Gamma-Aminobutyric Acid Release From Reticular Thalamic Nucleus: Role of T-Type Calcium Channels.

This chapter discusses cocaine-mediated actions on thalamic networks gamma-aminobutyric acid (GABA) transmission. Cocaine effects are associated with catecholamine reuptake inhibitions but local anesthetic mechanisms have been described. We focused our attention on the cocaine effects on thalamic re...

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Autores principales: Urbano, F.J., Bisagno, V.
Formato: CHAP
Materias:
Cocaine
GABAA receptors
Serotonin receptors
Thalamic reticular nucleus
Thalamocortical
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_97801280_v_n_p511_Urbano
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
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spelling todo:paper_97801280_v_n_p511_Urbano2023-10-03T16:42:42Z Cocaine Enhances Gamma-Aminobutyric Acid Release From Reticular Thalamic Nucleus: Role of T-Type Calcium Channels. Urbano, F.J. Bisagno, V. Cocaine GABAA receptors Serotonin receptors Thalamic reticular nucleus Thalamocortical This chapter discusses cocaine-mediated actions on thalamic networks gamma-aminobutyric acid (GABA) transmission. Cocaine effects are associated with catecholamine reuptake inhibitions but local anesthetic mechanisms have been described. We focused our attention on the cocaine effects on thalamic reticular nucleus, the main GABAergic afferents to sensory thalamic nuclei in rodents. Although cocaine can inhibit GABA release throughout the upregulation of presyanptic inhibitory serotonin (5-HT) 5-HT1A-typereceptors, local anesthetic-like effects of cocaine on thalamic reticular neurons can also contribute to the long-term thalamocortical alteration by this psychostimulant. Cocaine-mediated disruption of GABA neurotransmission might underlie aberrant thalamocortical physiology described in humans after repetitive cocaine use. © 2017 Elsevier Inc. All rights reserved. CHAP info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_97801280_v_n_p511_Urbano
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Cocaine
GABAA receptors
Serotonin receptors
Thalamic reticular nucleus
Thalamocortical
spellingShingle Cocaine
GABAA receptors
Serotonin receptors
Thalamic reticular nucleus
Thalamocortical
Urbano, F.J.
Bisagno, V.
Cocaine Enhances Gamma-Aminobutyric Acid Release From Reticular Thalamic Nucleus: Role of T-Type Calcium Channels.
topic_facet Cocaine
GABAA receptors
Serotonin receptors
Thalamic reticular nucleus
Thalamocortical
description This chapter discusses cocaine-mediated actions on thalamic networks gamma-aminobutyric acid (GABA) transmission. Cocaine effects are associated with catecholamine reuptake inhibitions but local anesthetic mechanisms have been described. We focused our attention on the cocaine effects on thalamic reticular nucleus, the main GABAergic afferents to sensory thalamic nuclei in rodents. Although cocaine can inhibit GABA release throughout the upregulation of presyanptic inhibitory serotonin (5-HT) 5-HT1A-typereceptors, local anesthetic-like effects of cocaine on thalamic reticular neurons can also contribute to the long-term thalamocortical alteration by this psychostimulant. Cocaine-mediated disruption of GABA neurotransmission might underlie aberrant thalamocortical physiology described in humans after repetitive cocaine use. © 2017 Elsevier Inc. All rights reserved.
format CHAP
author Urbano, F.J.
Bisagno, V.
author_facet Urbano, F.J.
Bisagno, V.
author_sort Urbano, F.J.
title Cocaine Enhances Gamma-Aminobutyric Acid Release From Reticular Thalamic Nucleus: Role of T-Type Calcium Channels.
title_short Cocaine Enhances Gamma-Aminobutyric Acid Release From Reticular Thalamic Nucleus: Role of T-Type Calcium Channels.
title_full Cocaine Enhances Gamma-Aminobutyric Acid Release From Reticular Thalamic Nucleus: Role of T-Type Calcium Channels.
title_fullStr Cocaine Enhances Gamma-Aminobutyric Acid Release From Reticular Thalamic Nucleus: Role of T-Type Calcium Channels.
title_full_unstemmed Cocaine Enhances Gamma-Aminobutyric Acid Release From Reticular Thalamic Nucleus: Role of T-Type Calcium Channels.
title_sort cocaine enhances gamma-aminobutyric acid release from reticular thalamic nucleus: role of t-type calcium channels.
url http://hdl.handle.net/20.500.12110/paper_97801280_v_n_p511_Urbano
work_keys_str_mv AT urbanofj cocaineenhancesgammaaminobutyricacidreleasefromreticularthalamicnucleusroleofttypecalciumchannels
AT bisagnov cocaineenhancesgammaaminobutyricacidreleasefromreticularthalamicnucleusroleofttypecalciumchannels
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