The Role of Heterotypic DENV-specific CD8+ T Lymphocytes in an Immunocompetent Mouse Model of Secondary Dengue Virus Infection

Dengue is the most prevalent arthropod-borne viral disease worldwide and is caused by the four dengue virus serotypes (DENV-1-4). Sequential heterologous DENV infections can be associated with severe disease manifestations. Here, we present an immunocompetent mouse model of secondary DENV infection...

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Detalles Bibliográficos
Autores principales: Talarico, L.B., Batalle, J.P., Byrne, A.B., Brahamian, J.M., Ferretti, A., García, A.G., Mauri, A., Simonetto, C., Hijano, D.R., Lawrence, A., Acosta, P.L., Caballero, M.T., Paredes Rojas, Y., Ibañez, L.I., Melendi, G.A., Rey, F.A., Damonte, E.B., Harris, E., Polack, F.P.
Formato: JOUR
Materias:
CD8+ T lymphocytes
Dengue virus
Immune response
Immunocompetent mouse model
Secondary infection
enrofloxacin
granzyme B
ketamine
tramadol
xylazine
immunoglobulin G
neutralizing antibody
T lymphocyte receptor
virus antibody
adoptive transfer
Aedes albopictus
alanine aminotransferase blood level
alkaline phosphatase blood level
animal cell
animal model
animal tissue
antibody response
antisepsis
Article
aspartate aminotransferase blood level
bleeding time
blood vessel permeability
CD8+ T lymphocyte
controlled study
creatine kinase blood level
dengue
Dengue virus 1
Dengue virus 2
depilation
female
flow cytometry
histopathology
Human respiratory syncytial virus
humoral immune deficiency
immunoassay
lactate dehydrogenase blood level
male
mouse
nonhuman
priority journal
real time polymerase chain reaction
RNA extraction
T cell depletion
thrombocyte count
ultraviolet irradiation
virus neutralization
virus titration
wound healing
animal
cell line
classification
cross reaction
disease model
immunology
knockout mouse
lymphocyte depletion
metabolism
serotype
severity of illness index
T lymphocyte subpopulation
virology
virus load
Animals
Antibodies, Neutralizing
Antibodies, Viral
CD8-Positive T-Lymphocytes
Cell Line
Cross Reactions
Dengue
Dengue Virus
Disease Models, Animal
Immunoglobulin G
Lymphocyte Depletion
Mice
Mice, Knockout
Serogroup
Severity of Illness Index
T-Cell Antigen Receptor Specificity
T-Lymphocyte Subsets
Viral Load
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_23523964_v20_n_p202_Talarico
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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