Delineating the "galectin signature" of the tumor microenvironment
Galectins, a family of glycan-binding proteins, can control tumor progression by promoting transformation, angiogenesis and immune escape. We identified a dynamically regulated 'galectin signature', which delineates the progression of prostate cancer, highlighting galectin-1 as an attracti...
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| Formato: | JOUR |
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_21624011_v2_n4_p_Compagno |
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todo:paper_21624011_v2_n4_p_Compagno2023-10-03T16:39:36Z Delineating the "galectin signature" of the tumor microenvironment Compagno, D. Laderach, J.D. Gentilini, L. Jaworski, M.F. Rabinovich, A.G. Angiogenesis Galectins Gene signature Metastasis Prostate cancer angiogenesis inhibitor ecalectin galectin galectin 1 galectin 12 galectin 3 galectin 4 galectin 8 messenger RNA short hairpin RNA unclassified drug advanced cancer antiangiogenic therapy article cancer cell culture cancer growth cancer prognosis cancer staging cancer therapy castration resistant prostate cancer cell invasion cell migration cellular immunity down regulation human hypoxia Kaposi sarcoma molecular mechanics prostate cancer prostatectomy protein carbohydrate interaction protein expression protein function protein structure protein synthesis inhibition protein targeting structure analysis tumor microenvironment tumor vascularization upregulation Galectins, a family of glycan-binding proteins, can control tumor progression by promoting transformation, angiogenesis and immune escape. We identified a dynamically regulated 'galectin signature', which delineates the progression of prostate cancer, highlighting galectin-1 as an attractive target for anti-angiogenic therapy in advanced stages of the disease. © 2013 Landes Bioscience. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_21624011_v2_n4_p_Compagno |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Angiogenesis Galectins Gene signature Metastasis Prostate cancer angiogenesis inhibitor ecalectin galectin galectin 1 galectin 12 galectin 3 galectin 4 galectin 8 messenger RNA short hairpin RNA unclassified drug advanced cancer antiangiogenic therapy article cancer cell culture cancer growth cancer prognosis cancer staging cancer therapy castration resistant prostate cancer cell invasion cell migration cellular immunity down regulation human hypoxia Kaposi sarcoma molecular mechanics prostate cancer prostatectomy protein carbohydrate interaction protein expression protein function protein structure protein synthesis inhibition protein targeting structure analysis tumor microenvironment tumor vascularization upregulation |
| spellingShingle |
Angiogenesis Galectins Gene signature Metastasis Prostate cancer angiogenesis inhibitor ecalectin galectin galectin 1 galectin 12 galectin 3 galectin 4 galectin 8 messenger RNA short hairpin RNA unclassified drug advanced cancer antiangiogenic therapy article cancer cell culture cancer growth cancer prognosis cancer staging cancer therapy castration resistant prostate cancer cell invasion cell migration cellular immunity down regulation human hypoxia Kaposi sarcoma molecular mechanics prostate cancer prostatectomy protein carbohydrate interaction protein expression protein function protein structure protein synthesis inhibition protein targeting structure analysis tumor microenvironment tumor vascularization upregulation Compagno, D. Laderach, J.D. Gentilini, L. Jaworski, M.F. Rabinovich, A.G. Delineating the "galectin signature" of the tumor microenvironment |
| topic_facet |
Angiogenesis Galectins Gene signature Metastasis Prostate cancer angiogenesis inhibitor ecalectin galectin galectin 1 galectin 12 galectin 3 galectin 4 galectin 8 messenger RNA short hairpin RNA unclassified drug advanced cancer antiangiogenic therapy article cancer cell culture cancer growth cancer prognosis cancer staging cancer therapy castration resistant prostate cancer cell invasion cell migration cellular immunity down regulation human hypoxia Kaposi sarcoma molecular mechanics prostate cancer prostatectomy protein carbohydrate interaction protein expression protein function protein structure protein synthesis inhibition protein targeting structure analysis tumor microenvironment tumor vascularization upregulation |
| description |
Galectins, a family of glycan-binding proteins, can control tumor progression by promoting transformation, angiogenesis and immune escape. We identified a dynamically regulated 'galectin signature', which delineates the progression of prostate cancer, highlighting galectin-1 as an attractive target for anti-angiogenic therapy in advanced stages of the disease. © 2013 Landes Bioscience. |
| format |
JOUR |
| author |
Compagno, D. Laderach, J.D. Gentilini, L. Jaworski, M.F. Rabinovich, A.G. |
| author_facet |
Compagno, D. Laderach, J.D. Gentilini, L. Jaworski, M.F. Rabinovich, A.G. |
| author_sort |
Compagno, D. |
| title |
Delineating the "galectin signature" of the tumor microenvironment |
| title_short |
Delineating the "galectin signature" of the tumor microenvironment |
| title_full |
Delineating the "galectin signature" of the tumor microenvironment |
| title_fullStr |
Delineating the "galectin signature" of the tumor microenvironment |
| title_full_unstemmed |
Delineating the "galectin signature" of the tumor microenvironment |
| title_sort |
delineating the "galectin signature" of the tumor microenvironment |
| url |
http://hdl.handle.net/20.500.12110/paper_21624011_v2_n4_p_Compagno |
| work_keys_str_mv |
AT compagnod delineatingthegalectinsignatureofthetumormicroenvironment AT laderachjd delineatingthegalectinsignatureofthetumormicroenvironment AT gentilinil delineatingthegalectinsignatureofthetumormicroenvironment AT jaworskimf delineatingthegalectinsignatureofthetumormicroenvironment AT rabinovichag delineatingthegalectinsignatureofthetumormicroenvironment |
| _version_ |
1807324376851283968 |