Core promoter information content correlates with optimal growth temperature
The subtle mechanisms by which protein-DNA interactions remain functional across a wide range of temperatures are largely unknown. In this work, we manually curated available information relating fully sequenced archaeal genomes with organism growth temperatures. We built a motif that represents the...
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todo:paper_20452322_v8_n1_p_Aptekmann2023-10-03T16:38:22Z Core promoter information content correlates with optimal growth temperature Aptekmann, A.A. Nadra, A.D. transfer RNA archaeal genome archaeon DNA base composition genetics heat tolerance physiology promoter region Archaea Base Composition Genome, Archaeal Promoter Regions, Genetic RNA, Transfer Thermotolerance The subtle mechanisms by which protein-DNA interactions remain functional across a wide range of temperatures are largely unknown. In this work, we manually curated available information relating fully sequenced archaeal genomes with organism growth temperatures. We built a motif that represents the core promoter of each species and calculated its information content. We then studied the relation between optimal growth temperature (OGT) and information content (IC) in the promoter region.We found a positive correlation between G + C content and OGT in tRNA regions and not in overall genome. Furthermore, we found that there is a positive correlation between information content and optimal growth temperatures in Archaea. This can't be explained by an increased C+G composition nor by other obvious mechanisms. These findings suggest that increased information content could produce a positive fitness in organisms living at high temperatures. We suggest that molecular information theory may need to be adapted for hyperthermophiles. © 2018 The Author(s). JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_20452322_v8_n1_p_Aptekmann |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
transfer RNA archaeal genome archaeon DNA base composition genetics heat tolerance physiology promoter region Archaea Base Composition Genome, Archaeal Promoter Regions, Genetic RNA, Transfer Thermotolerance |
spellingShingle |
transfer RNA archaeal genome archaeon DNA base composition genetics heat tolerance physiology promoter region Archaea Base Composition Genome, Archaeal Promoter Regions, Genetic RNA, Transfer Thermotolerance Aptekmann, A.A. Nadra, A.D. Core promoter information content correlates with optimal growth temperature |
topic_facet |
transfer RNA archaeal genome archaeon DNA base composition genetics heat tolerance physiology promoter region Archaea Base Composition Genome, Archaeal Promoter Regions, Genetic RNA, Transfer Thermotolerance |
description |
The subtle mechanisms by which protein-DNA interactions remain functional across a wide range of temperatures are largely unknown. In this work, we manually curated available information relating fully sequenced archaeal genomes with organism growth temperatures. We built a motif that represents the core promoter of each species and calculated its information content. We then studied the relation between optimal growth temperature (OGT) and information content (IC) in the promoter region.We found a positive correlation between G + C content and OGT in tRNA regions and not in overall genome. Furthermore, we found that there is a positive correlation between information content and optimal growth temperatures in Archaea. This can't be explained by an increased C+G composition nor by other obvious mechanisms. These findings suggest that increased information content could produce a positive fitness in organisms living at high temperatures. We suggest that molecular information theory may need to be adapted for hyperthermophiles. © 2018 The Author(s). |
format |
JOUR |
author |
Aptekmann, A.A. Nadra, A.D. |
author_facet |
Aptekmann, A.A. Nadra, A.D. |
author_sort |
Aptekmann, A.A. |
title |
Core promoter information content correlates with optimal growth temperature |
title_short |
Core promoter information content correlates with optimal growth temperature |
title_full |
Core promoter information content correlates with optimal growth temperature |
title_fullStr |
Core promoter information content correlates with optimal growth temperature |
title_full_unstemmed |
Core promoter information content correlates with optimal growth temperature |
title_sort |
core promoter information content correlates with optimal growth temperature |
url |
http://hdl.handle.net/20.500.12110/paper_20452322_v8_n1_p_Aptekmann |
work_keys_str_mv |
AT aptekmannaa corepromoterinformationcontentcorrelateswithoptimalgrowthtemperature AT nadraad corepromoterinformationcontentcorrelateswithoptimalgrowthtemperature |
_version_ |
1782030531016261632 |