Host cell factors as antiviral targets in arenavirus infection
Among the members of the Arenaviridae family, Lassa virus and Junin virus generate periodic annual outbreaks of severe human hemorrhagic fever (HF) in endemic areas of West Africa and Argentina, respectively. Given the human health threat that arenaviruses represent and the lack of a specific and sa...
Guardado en:
| Autores principales: | , , , , , , |
|---|---|
| Formato: | JOUR |
| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_19994915_v4_n9_p1569_Linero |
| Aporte de: |
| id |
todo:paper_19994915_v4_n9_p1569_Linero |
|---|---|
| record_format |
dspace |
| spelling |
todo:paper_19994915_v4_n9_p1569_Linero2023-10-03T16:37:36Z Host cell factors as antiviral targets in arenavirus infection Linero, F.N. Sepúlveda, C.S. Giovannoni, F. Castilla, V. García, C.C. Scolaro, L.A. Damonte, E.B. Antiviral Arenavirus Hemorrhagic fever Host cell target Junin virus cell protein heterogeneous nuclear ribonucleoprotein host factor interferon nucleoside phosphotransferase arenavirus infection down regulation host cell human immune response nonhuman outcome assessment protein expression protein localization protein phosphorylation review RNA processing RNA synthesis target cell upregulation virus cell interaction virus entry virus infectivity virus replication virus resistance Antiviral Agents Arenaviridae Infections Arenavirus Host-Pathogen Interactions Humans Arenaviridae Arenavirus Junin virus Lassa virus RNA viruses Among the members of the Arenaviridae family, Lassa virus and Junin virus generate periodic annual outbreaks of severe human hemorrhagic fever (HF) in endemic areas of West Africa and Argentina, respectively. Given the human health threat that arenaviruses represent and the lack of a specific and safe chemotherapy, the search for effective antiviral compounds is a continuous demanding effort. Since diverse host cell pathways and enzymes are used by RNA viruses to fulfill their replicative cycle, the targeting of a host process has turned an attractive antiviral approach in the last years for many unrelated virus types. This strategy has the additional benefit to reduce the serious challenge for therapy of RNA viruses to escape from drug effects through selection of resistant variants triggered by their high mutation rate. This article focuses on novel strategies to identify inhibitors for arenavirus therapy, analyzing the potential for antiviral developments of diverse host factors essential for virus infection. © 2012 by the authors licensee MDPI, Basel, Switzerland. Fil:Linero, F.N. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Sepúlveda, C.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Castilla, V. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:García, C.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Scolaro, L.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Damonte, E.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_19994915_v4_n9_p1569_Linero |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Antiviral Arenavirus Hemorrhagic fever Host cell target Junin virus cell protein heterogeneous nuclear ribonucleoprotein host factor interferon nucleoside phosphotransferase arenavirus infection down regulation host cell human immune response nonhuman outcome assessment protein expression protein localization protein phosphorylation review RNA processing RNA synthesis target cell upregulation virus cell interaction virus entry virus infectivity virus replication virus resistance Antiviral Agents Arenaviridae Infections Arenavirus Host-Pathogen Interactions Humans Arenaviridae Arenavirus Junin virus Lassa virus RNA viruses |
| spellingShingle |
Antiviral Arenavirus Hemorrhagic fever Host cell target Junin virus cell protein heterogeneous nuclear ribonucleoprotein host factor interferon nucleoside phosphotransferase arenavirus infection down regulation host cell human immune response nonhuman outcome assessment protein expression protein localization protein phosphorylation review RNA processing RNA synthesis target cell upregulation virus cell interaction virus entry virus infectivity virus replication virus resistance Antiviral Agents Arenaviridae Infections Arenavirus Host-Pathogen Interactions Humans Arenaviridae Arenavirus Junin virus Lassa virus RNA viruses Linero, F.N. Sepúlveda, C.S. Giovannoni, F. Castilla, V. García, C.C. Scolaro, L.A. Damonte, E.B. Host cell factors as antiviral targets in arenavirus infection |
| topic_facet |
Antiviral Arenavirus Hemorrhagic fever Host cell target Junin virus cell protein heterogeneous nuclear ribonucleoprotein host factor interferon nucleoside phosphotransferase arenavirus infection down regulation host cell human immune response nonhuman outcome assessment protein expression protein localization protein phosphorylation review RNA processing RNA synthesis target cell upregulation virus cell interaction virus entry virus infectivity virus replication virus resistance Antiviral Agents Arenaviridae Infections Arenavirus Host-Pathogen Interactions Humans Arenaviridae Arenavirus Junin virus Lassa virus RNA viruses |
| description |
Among the members of the Arenaviridae family, Lassa virus and Junin virus generate periodic annual outbreaks of severe human hemorrhagic fever (HF) in endemic areas of West Africa and Argentina, respectively. Given the human health threat that arenaviruses represent and the lack of a specific and safe chemotherapy, the search for effective antiviral compounds is a continuous demanding effort. Since diverse host cell pathways and enzymes are used by RNA viruses to fulfill their replicative cycle, the targeting of a host process has turned an attractive antiviral approach in the last years for many unrelated virus types. This strategy has the additional benefit to reduce the serious challenge for therapy of RNA viruses to escape from drug effects through selection of resistant variants triggered by their high mutation rate. This article focuses on novel strategies to identify inhibitors for arenavirus therapy, analyzing the potential for antiviral developments of diverse host factors essential for virus infection. © 2012 by the authors licensee MDPI, Basel, Switzerland. |
| format |
JOUR |
| author |
Linero, F.N. Sepúlveda, C.S. Giovannoni, F. Castilla, V. García, C.C. Scolaro, L.A. Damonte, E.B. |
| author_facet |
Linero, F.N. Sepúlveda, C.S. Giovannoni, F. Castilla, V. García, C.C. Scolaro, L.A. Damonte, E.B. |
| author_sort |
Linero, F.N. |
| title |
Host cell factors as antiviral targets in arenavirus infection |
| title_short |
Host cell factors as antiviral targets in arenavirus infection |
| title_full |
Host cell factors as antiviral targets in arenavirus infection |
| title_fullStr |
Host cell factors as antiviral targets in arenavirus infection |
| title_full_unstemmed |
Host cell factors as antiviral targets in arenavirus infection |
| title_sort |
host cell factors as antiviral targets in arenavirus infection |
| url |
http://hdl.handle.net/20.500.12110/paper_19994915_v4_n9_p1569_Linero |
| work_keys_str_mv |
AT linerofn hostcellfactorsasantiviraltargetsinarenavirusinfection AT sepulvedacs hostcellfactorsasantiviraltargetsinarenavirusinfection AT giovannonif hostcellfactorsasantiviraltargetsinarenavirusinfection AT castillav hostcellfactorsasantiviraltargetsinarenavirusinfection AT garciacc hostcellfactorsasantiviraltargetsinarenavirusinfection AT scolarola hostcellfactorsasantiviraltargetsinarenavirusinfection AT damonteeb hostcellfactorsasantiviraltargetsinarenavirusinfection |
| _version_ |
1782023658722557952 |