A Visible-Light-Sensitive Caged Serotonin

Serotonin, or 5-hydroxytryptamine (5HT), is an important neurotransmitter in the nervous system of both vertebrates and invertebrates. Deficits in 5HT signaling are responsible for many disabling psychiatric conditions, and its molecular machinery is the target of many pharmaceuticals. We present a...

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Detalles Bibliográficos
Autores principales: Cabrera, R., Filevich, O., García-Acosta, B., Athilingam, J., Bender, K.J., Poskanzer, K.E., Etchenique, R.
Formato: JOUR
Materias:
neurophysiology
phototriggers
Ruthenium complex
serotonin
ruthenium
animal cell
Article
light absorption
mouse
nerve cell excitability
nonhuman
pH
photochemistry
photolysis
photosensitivity
priority journal
proton nuclear magnetic resonance
pyramidal nerve cell
quantum yield
animal
chemistry
drug effects
light
metabolism
nerve cell
prefrontal cortex
Animals
Light
Mice
Neurons
Prefrontal Cortex
Ruthenium
Serotonin
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_19487193_v8_n5_p1036_Cabrera
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Serotonin, or 5-hydroxytryptamine (5HT), is an important neurotransmitter in the nervous system of both vertebrates and invertebrates. Deficits in 5HT signaling are responsible for many disabling psychiatric conditions, and its molecular machinery is the target of many pharmaceuticals. We present a new 5HT phototrigger, the compound [Ru(bpy)2(PMe3)(5HT)]2+, where PMe3 is trimethylphosphine. As with other ruthenium-bipyridyl based caged compounds, [Ru(bpy)2(PMe3)(5HT)]2+ presents activity in the visible region of the spectrum. We characterize and discuss the photochemical properties of the caged compound, and demonstrate its use by modulating the excitability of mouse prefrontal principal neurons. © 2017 American Chemical Society.

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