A Visible-Light-Sensitive Caged Serotonin
Serotonin, or 5-hydroxytryptamine (5HT), is an important neurotransmitter in the nervous system of both vertebrates and invertebrates. Deficits in 5HT signaling are responsible for many disabling psychiatric conditions, and its molecular machinery is the target of many pharmaceuticals. We present a...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_19487193_v8_n5_p1036_Cabrera |
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todo:paper_19487193_v8_n5_p1036_Cabrera2023-10-03T16:37:13Z A Visible-Light-Sensitive Caged Serotonin Cabrera, R. Filevich, O. García-Acosta, B. Athilingam, J. Bender, K.J. Poskanzer, K.E. Etchenique, R. neurophysiology phototriggers Ruthenium complex serotonin serotonin ruthenium serotonin animal cell Article light absorption mouse nerve cell excitability nonhuman pH photochemistry photolysis photosensitivity priority journal proton nuclear magnetic resonance pyramidal nerve cell quantum yield animal chemistry drug effects light metabolism nerve cell prefrontal cortex Animals Light Mice Neurons Prefrontal Cortex Ruthenium Serotonin Serotonin, or 5-hydroxytryptamine (5HT), is an important neurotransmitter in the nervous system of both vertebrates and invertebrates. Deficits in 5HT signaling are responsible for many disabling psychiatric conditions, and its molecular machinery is the target of many pharmaceuticals. We present a new 5HT phototrigger, the compound [Ru(bpy)2(PMe3)(5HT)]2+, where PMe3 is trimethylphosphine. As with other ruthenium-bipyridyl based caged compounds, [Ru(bpy)2(PMe3)(5HT)]2+ presents activity in the visible region of the spectrum. We characterize and discuss the photochemical properties of the caged compound, and demonstrate its use by modulating the excitability of mouse prefrontal principal neurons. © 2017 American Chemical Society. Fil:Filevich, O. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:García-Acosta, B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Etchenique, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_19487193_v8_n5_p1036_Cabrera |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
neurophysiology phototriggers Ruthenium complex serotonin serotonin ruthenium serotonin animal cell Article light absorption mouse nerve cell excitability nonhuman pH photochemistry photolysis photosensitivity priority journal proton nuclear magnetic resonance pyramidal nerve cell quantum yield animal chemistry drug effects light metabolism nerve cell prefrontal cortex Animals Light Mice Neurons Prefrontal Cortex Ruthenium Serotonin |
| spellingShingle |
neurophysiology phototriggers Ruthenium complex serotonin serotonin ruthenium serotonin animal cell Article light absorption mouse nerve cell excitability nonhuman pH photochemistry photolysis photosensitivity priority journal proton nuclear magnetic resonance pyramidal nerve cell quantum yield animal chemistry drug effects light metabolism nerve cell prefrontal cortex Animals Light Mice Neurons Prefrontal Cortex Ruthenium Serotonin Cabrera, R. Filevich, O. García-Acosta, B. Athilingam, J. Bender, K.J. Poskanzer, K.E. Etchenique, R. A Visible-Light-Sensitive Caged Serotonin |
| topic_facet |
neurophysiology phototriggers Ruthenium complex serotonin serotonin ruthenium serotonin animal cell Article light absorption mouse nerve cell excitability nonhuman pH photochemistry photolysis photosensitivity priority journal proton nuclear magnetic resonance pyramidal nerve cell quantum yield animal chemistry drug effects light metabolism nerve cell prefrontal cortex Animals Light Mice Neurons Prefrontal Cortex Ruthenium Serotonin |
| description |
Serotonin, or 5-hydroxytryptamine (5HT), is an important neurotransmitter in the nervous system of both vertebrates and invertebrates. Deficits in 5HT signaling are responsible for many disabling psychiatric conditions, and its molecular machinery is the target of many pharmaceuticals. We present a new 5HT phototrigger, the compound [Ru(bpy)2(PMe3)(5HT)]2+, where PMe3 is trimethylphosphine. As with other ruthenium-bipyridyl based caged compounds, [Ru(bpy)2(PMe3)(5HT)]2+ presents activity in the visible region of the spectrum. We characterize and discuss the photochemical properties of the caged compound, and demonstrate its use by modulating the excitability of mouse prefrontal principal neurons. © 2017 American Chemical Society. |
| format |
JOUR |
| author |
Cabrera, R. Filevich, O. García-Acosta, B. Athilingam, J. Bender, K.J. Poskanzer, K.E. Etchenique, R. |
| author_facet |
Cabrera, R. Filevich, O. García-Acosta, B. Athilingam, J. Bender, K.J. Poskanzer, K.E. Etchenique, R. |
| author_sort |
Cabrera, R. |
| title |
A Visible-Light-Sensitive Caged Serotonin |
| title_short |
A Visible-Light-Sensitive Caged Serotonin |
| title_full |
A Visible-Light-Sensitive Caged Serotonin |
| title_fullStr |
A Visible-Light-Sensitive Caged Serotonin |
| title_full_unstemmed |
A Visible-Light-Sensitive Caged Serotonin |
| title_sort |
visible-light-sensitive caged serotonin |
| url |
http://hdl.handle.net/20.500.12110/paper_19487193_v8_n5_p1036_Cabrera |
| work_keys_str_mv |
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| _version_ |
1782024321587216384 |