Theoretical biology: Response to comment on "'Load-induced modulation of signal transduction networks': Reconciling ultrasensitivity with bifunctionality?"
Straube suggests that a model that reflects the bifunctional nature of the cycle enzyme uridylyltransferase/uridylyl-removing enzyme (UTase/UR) should be used, in which the UT and UR activities are distinct and reciprocally regulated activity states of the enzyme, and notes that if such a model is u...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_19450877_v5_n205_p_Jiang |
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todo:paper_19450877_v5_n205_p_Jiang2023-10-03T16:37:05Z Theoretical biology: Response to comment on "'Load-induced modulation of signal transduction networks': Reconciling ultrasensitivity with bifunctionality?" Jiang, P. Ventura, A.C. Sontag, E.D. Merajver, S.D. Ninfa, A.J. Del Vecchio, D. hexose 1 phosphate uridylyltransferase article enzyme activation enzyme activity enzyme regulation Escherichia coli modulation nonhuman prediction priority journal signal transduction Straube suggests that a model that reflects the bifunctional nature of the cycle enzyme uridylyltransferase/uridylyl-removing enzyme (UTase/UR) should be used, in which the UT and UR activities are distinct and reciprocally regulated activity states of the enzyme, and notes that if such a model is used, the effects of retroactivity at intermediate stimulation will be different. However, such a model does not accurately match the observed enzyme regulatory properties and fails to predict the ultrasensitive response obtained in the experiments. Here, we argue that modeling the UTase/UR enzyme as a bifunctional enzyme with reciprocally regulated activity states misses important aspects of the system. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_19450877_v5_n205_p_Jiang |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
hexose 1 phosphate uridylyltransferase article enzyme activation enzyme activity enzyme regulation Escherichia coli modulation nonhuman prediction priority journal signal transduction |
| spellingShingle |
hexose 1 phosphate uridylyltransferase article enzyme activation enzyme activity enzyme regulation Escherichia coli modulation nonhuman prediction priority journal signal transduction Jiang, P. Ventura, A.C. Sontag, E.D. Merajver, S.D. Ninfa, A.J. Del Vecchio, D. Theoretical biology: Response to comment on "'Load-induced modulation of signal transduction networks': Reconciling ultrasensitivity with bifunctionality?" |
| topic_facet |
hexose 1 phosphate uridylyltransferase article enzyme activation enzyme activity enzyme regulation Escherichia coli modulation nonhuman prediction priority journal signal transduction |
| description |
Straube suggests that a model that reflects the bifunctional nature of the cycle enzyme uridylyltransferase/uridylyl-removing enzyme (UTase/UR) should be used, in which the UT and UR activities are distinct and reciprocally regulated activity states of the enzyme, and notes that if such a model is used, the effects of retroactivity at intermediate stimulation will be different. However, such a model does not accurately match the observed enzyme regulatory properties and fails to predict the ultrasensitive response obtained in the experiments. Here, we argue that modeling the UTase/UR enzyme as a bifunctional enzyme with reciprocally regulated activity states misses important aspects of the system. |
| format |
JOUR |
| author |
Jiang, P. Ventura, A.C. Sontag, E.D. Merajver, S.D. Ninfa, A.J. Del Vecchio, D. |
| author_facet |
Jiang, P. Ventura, A.C. Sontag, E.D. Merajver, S.D. Ninfa, A.J. Del Vecchio, D. |
| author_sort |
Jiang, P. |
| title |
Theoretical biology: Response to comment on "'Load-induced modulation of signal transduction networks': Reconciling ultrasensitivity with bifunctionality?" |
| title_short |
Theoretical biology: Response to comment on "'Load-induced modulation of signal transduction networks': Reconciling ultrasensitivity with bifunctionality?" |
| title_full |
Theoretical biology: Response to comment on "'Load-induced modulation of signal transduction networks': Reconciling ultrasensitivity with bifunctionality?" |
| title_fullStr |
Theoretical biology: Response to comment on "'Load-induced modulation of signal transduction networks': Reconciling ultrasensitivity with bifunctionality?" |
| title_full_unstemmed |
Theoretical biology: Response to comment on "'Load-induced modulation of signal transduction networks': Reconciling ultrasensitivity with bifunctionality?" |
| title_sort |
theoretical biology: response to comment on "'load-induced modulation of signal transduction networks': reconciling ultrasensitivity with bifunctionality?" |
| url |
http://hdl.handle.net/20.500.12110/paper_19450877_v5_n205_p_Jiang |
| work_keys_str_mv |
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