Novel mRNA-silencing bodies at the synapse: A never-ending story

Several cellular responses depend on translational regulation and in most cases, this involves the formation of cytoplasmic granules that contain repressed mRNAs. In neurons, numerous mRNAs travel along dendrites to be locally regulated upon synapse activity and we have recently shown that the exori...

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Detalles Bibliográficos
Autores principales: Thomas, M.G., Boccaccio, G.L.
Formato: JOUR
Materias:
DHPG
FMRP
NMDA
Samd4
Smaug
XRN1
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_19420889_v9_n2_p1_Thomas
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_19420889_v9_n2_p1_Thomas
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spelling todo:paper_19420889_v9_n2_p1_Thomas2023-10-03T16:36:57Z Novel mRNA-silencing bodies at the synapse: A never-ending story Thomas, M.G. Boccaccio, G.L. DHPG FMRP NMDA Samd4 Smaug XRN1 Several cellular responses depend on translational regulation and in most cases, this involves the formation of cytoplasmic granules that contain repressed mRNAs. In neurons, numerous mRNAs travel along dendrites to be locally regulated upon synapse activity and we have recently shown that the exoribonuclease XRN1 forms dynamic aggregates at the post synapse that respond to specific stimuli.1 These foci were termed SX-bodies and are distinct from stress granules (SGs), processing bodies (PBs) and other RNA granules previously described. Together with Smaug1-foci and FMRP-granules, the SX-bodies contribute to dynamically shape the transcriptome available for translation at the post-synapse. © 2016 María Gabriela Thomas and Graciela Lidia Boccaccio. Fil:Thomas, M.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Boccaccio, G.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_19420889_v9_n2_p1_Thomas
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic DHPG
FMRP
NMDA
Samd4
Smaug
XRN1
spellingShingle DHPG
FMRP
NMDA
Samd4
Smaug
XRN1
Thomas, M.G.
Boccaccio, G.L.
Novel mRNA-silencing bodies at the synapse: A never-ending story
topic_facet DHPG
FMRP
NMDA
Samd4
Smaug
XRN1
description Several cellular responses depend on translational regulation and in most cases, this involves the formation of cytoplasmic granules that contain repressed mRNAs. In neurons, numerous mRNAs travel along dendrites to be locally regulated upon synapse activity and we have recently shown that the exoribonuclease XRN1 forms dynamic aggregates at the post synapse that respond to specific stimuli.1 These foci were termed SX-bodies and are distinct from stress granules (SGs), processing bodies (PBs) and other RNA granules previously described. Together with Smaug1-foci and FMRP-granules, the SX-bodies contribute to dynamically shape the transcriptome available for translation at the post-synapse. © 2016 María Gabriela Thomas and Graciela Lidia Boccaccio.
format JOUR
author Thomas, M.G.
Boccaccio, G.L.
author_facet Thomas, M.G.
Boccaccio, G.L.
author_sort Thomas, M.G.
title Novel mRNA-silencing bodies at the synapse: A never-ending story
title_short Novel mRNA-silencing bodies at the synapse: A never-ending story
title_full Novel mRNA-silencing bodies at the synapse: A never-ending story
title_fullStr Novel mRNA-silencing bodies at the synapse: A never-ending story
title_full_unstemmed Novel mRNA-silencing bodies at the synapse: A never-ending story
title_sort novel mrna-silencing bodies at the synapse: a never-ending story
url http://hdl.handle.net/20.500.12110/paper_19420889_v9_n2_p1_Thomas
work_keys_str_mv AT thomasmg novelmrnasilencingbodiesatthesynapseaneverendingstory
AT boccacciogl novelmrnasilencingbodiesatthesynapseaneverendingstory
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