Virucidal activity and chemical composition of essential oils from aromatic plants of central west Argentina
The essential oils of seven aromatic plants from central west Argentina were isolated by steam distillation and analyzed by a gas chromatography/mass spectrometry technique. The oils were screened for cytotoxicity and in vitro inhibitory activity against herpes simplex virus type 1 (HSV-1), dengue v...
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todo:paper_1934578X_v5_n8_p1307_Garcia2023-10-03T16:36:15Z Virucidal activity and chemical composition of essential oils from aromatic plants of central west Argentina García, C.C. Acosta, E.G. Carro, A.C. Belmonte, M.C.F. Bomben, R. Duschatzky, C.B. Perotti, M. Schuff, C. Damonte, E.B. Dengue virus Essential oil Herpes simplex virus Junin virus Virucidal activity essential oil Lantana grisebachii essential oil unclassified drug antivirus agent essential oil animal cell antiviral activity article chemical composition controlled study Dengue virus 2 distillation drug cytotoxicity drug isolation Herpes simplex virus 1 IC 50 Junin virus Lantana Lantana grisebachii nonhuman virus inactivation virus strain Argentina chemistry Dengue virus drug effects isolation and purification medicinal plant Dengue virus Dengue virus type 2 Herpesviridae Human herpesvirus 1 Human herpesvirus 2 Junin virus Lantana Simplexvirus Antiviral Agents Argentina Dengue Virus Herpesvirus 1, Human Junin virus Lantana Oils, Volatile Plants, Medicinal The essential oils of seven aromatic plants from central west Argentina were isolated by steam distillation and analyzed by a gas chromatography/mass spectrometry technique. The oils were screened for cytotoxicity and in vitro inhibitory activity against herpes simplex virus type 1 (HSV-1), dengue virus type 2 (DENV-2) and Junin virus (JUNV). The oils showed a variable virucidal action according to the virus. JUNV was the least susceptible virus in comparison with HSV-1 and DENV-2. The better relationship between cytotoxicity and inhibitory activity was observed for the essential oil of Lantana grisebachiii (Seckt.) var. grisebachii against DENV-2 and HSV-1 with IC50 (inhibitory concentration 50%) values of 21.1 and 26.1 ppm, respectively. This effect was specific since the selectivity indices (ratio cytotoxicity/virucidal activity) were > 23.7 and > 19.1 for DENV-2 and HSV-1, respectively. Furthermore, the oil from L. grisebachii was also an effective inhibitor of HSV-2 and acyclovir resistant variants of herpes virus. This study demonstrates the effective and selective inhibitory activity of the essential oil from Lantana grisebachii against HSV and DENV by direct virus inactivation. Fil:García, C.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Acosta, E.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Damonte, E.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_1934578X_v5_n8_p1307_Garcia |
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Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Dengue virus Essential oil Herpes simplex virus Junin virus Virucidal activity essential oil Lantana grisebachii essential oil unclassified drug antivirus agent essential oil animal cell antiviral activity article chemical composition controlled study Dengue virus 2 distillation drug cytotoxicity drug isolation Herpes simplex virus 1 IC 50 Junin virus Lantana Lantana grisebachii nonhuman virus inactivation virus strain Argentina chemistry Dengue virus drug effects isolation and purification medicinal plant Dengue virus Dengue virus type 2 Herpesviridae Human herpesvirus 1 Human herpesvirus 2 Junin virus Lantana Simplexvirus Antiviral Agents Argentina Dengue Virus Herpesvirus 1, Human Junin virus Lantana Oils, Volatile Plants, Medicinal |
| spellingShingle |
Dengue virus Essential oil Herpes simplex virus Junin virus Virucidal activity essential oil Lantana grisebachii essential oil unclassified drug antivirus agent essential oil animal cell antiviral activity article chemical composition controlled study Dengue virus 2 distillation drug cytotoxicity drug isolation Herpes simplex virus 1 IC 50 Junin virus Lantana Lantana grisebachii nonhuman virus inactivation virus strain Argentina chemistry Dengue virus drug effects isolation and purification medicinal plant Dengue virus Dengue virus type 2 Herpesviridae Human herpesvirus 1 Human herpesvirus 2 Junin virus Lantana Simplexvirus Antiviral Agents Argentina Dengue Virus Herpesvirus 1, Human Junin virus Lantana Oils, Volatile Plants, Medicinal García, C.C. Acosta, E.G. Carro, A.C. Belmonte, M.C.F. Bomben, R. Duschatzky, C.B. Perotti, M. Schuff, C. Damonte, E.B. Virucidal activity and chemical composition of essential oils from aromatic plants of central west Argentina |
| topic_facet |
Dengue virus Essential oil Herpes simplex virus Junin virus Virucidal activity essential oil Lantana grisebachii essential oil unclassified drug antivirus agent essential oil animal cell antiviral activity article chemical composition controlled study Dengue virus 2 distillation drug cytotoxicity drug isolation Herpes simplex virus 1 IC 50 Junin virus Lantana Lantana grisebachii nonhuman virus inactivation virus strain Argentina chemistry Dengue virus drug effects isolation and purification medicinal plant Dengue virus Dengue virus type 2 Herpesviridae Human herpesvirus 1 Human herpesvirus 2 Junin virus Lantana Simplexvirus Antiviral Agents Argentina Dengue Virus Herpesvirus 1, Human Junin virus Lantana Oils, Volatile Plants, Medicinal |
| description |
The essential oils of seven aromatic plants from central west Argentina were isolated by steam distillation and analyzed by a gas chromatography/mass spectrometry technique. The oils were screened for cytotoxicity and in vitro inhibitory activity against herpes simplex virus type 1 (HSV-1), dengue virus type 2 (DENV-2) and Junin virus (JUNV). The oils showed a variable virucidal action according to the virus. JUNV was the least susceptible virus in comparison with HSV-1 and DENV-2. The better relationship between cytotoxicity and inhibitory activity was observed for the essential oil of Lantana grisebachiii (Seckt.) var. grisebachii against DENV-2 and HSV-1 with IC50 (inhibitory concentration 50%) values of 21.1 and 26.1 ppm, respectively. This effect was specific since the selectivity indices (ratio cytotoxicity/virucidal activity) were > 23.7 and > 19.1 for DENV-2 and HSV-1, respectively. Furthermore, the oil from L. grisebachii was also an effective inhibitor of HSV-2 and acyclovir resistant variants of herpes virus. This study demonstrates the effective and selective inhibitory activity of the essential oil from Lantana grisebachii against HSV and DENV by direct virus inactivation. |
| format |
JOUR |
| author |
García, C.C. Acosta, E.G. Carro, A.C. Belmonte, M.C.F. Bomben, R. Duschatzky, C.B. Perotti, M. Schuff, C. Damonte, E.B. |
| author_facet |
García, C.C. Acosta, E.G. Carro, A.C. Belmonte, M.C.F. Bomben, R. Duschatzky, C.B. Perotti, M. Schuff, C. Damonte, E.B. |
| author_sort |
García, C.C. |
| title |
Virucidal activity and chemical composition of essential oils from aromatic plants of central west Argentina |
| title_short |
Virucidal activity and chemical composition of essential oils from aromatic plants of central west Argentina |
| title_full |
Virucidal activity and chemical composition of essential oils from aromatic plants of central west Argentina |
| title_fullStr |
Virucidal activity and chemical composition of essential oils from aromatic plants of central west Argentina |
| title_full_unstemmed |
Virucidal activity and chemical composition of essential oils from aromatic plants of central west Argentina |
| title_sort |
virucidal activity and chemical composition of essential oils from aromatic plants of central west argentina |
| url |
http://hdl.handle.net/20.500.12110/paper_1934578X_v5_n8_p1307_Garcia |
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