The neural basis of decision-making and reward processing in adults with euthymic bipolar disorder or attention-deficit/hyperactivity disorder (ADHD)
Background: Attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BD) share DSM-IV criteria in adults and cause problems in decision-making. Nevertheless, no previous report has assessed a decision-making task that includes the examination of the neural correlates of reward and gambl...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | JOUR |
| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_19326203_v7_n5_p_Ibanez |
| Aporte de: |
| id |
todo:paper_19326203_v7_n5_p_Ibanez |
|---|---|
| record_format |
dspace |
| spelling |
todo:paper_19326203_v7_n5_p_Ibanez2023-10-03T16:35:21Z The neural basis of decision-making and reward processing in adults with euthymic bipolar disorder or attention-deficit/hyperactivity disorder (ADHD) Ibanez, A. Cetkovich, M. Petroni, A. Urquina, H. Baez, S. Gonzalez-Gadea, M.L. Kamienkowski, J.E. Torralva, T. Torrente, F. Strejilevich, S. Teitelbaum, J. Hurtado, E. Guex, R. Melloni, M. Lischinsky, A. Sigman, M. Manes, F. adult anterior cingulate article attention deficit disorder behavior bipolar disorder clinical article controlled study decision making event related potential executive function feedback system female human hyperactivity impulsiveness Iowa Gambling Task learning disorder male mood disorder motivation neurobiology neurophysiology neuropsychological test rapid decision gambling task response time reward working memory analysis of variance biological model cingulate gyrus learning pathological gambling pathophysiology physiology reinforcement reward risk Filicophyta Adult Analysis of Variance Attention Deficit Disorder with Hyperactivity Bipolar Disorder Decision Making Gambling Gyrus Cinguli Humans Learning Models, Neurological Neuropsychological Tests Reinforcement (Psychology) Reward Risk Background: Attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BD) share DSM-IV criteria in adults and cause problems in decision-making. Nevertheless, no previous report has assessed a decision-making task that includes the examination of the neural correlates of reward and gambling in adults with ADHD and those with BD. Methodology/Principal Findings: We used the Iowa gambling task (IGT), a task of rational decision-making under risk (RDMUR) and a rapid-decision gambling task (RDGT) which elicits behavioral measures as well as event-related potentials (ERPs: fERN and P3) in connection to the motivational impact of events. We did not observe between-group differences for decision-making under risk or ambiguity (RDMUR and IGT); however, there were significant differences for the ERP-assessed RDGT. Compared to controls, the ADHD group showed a pattern of impaired learning by feedback (fERN) and insensitivity to reward magnitude (P3). This ERP pattern (fERN and P3) was associated with impulsivity, hyperactivity, executive function and working memory. Compared to controls, the BD group showed fERN- and P3-enhanced responses to reward magnitude regardless of valence. This ERP pattern (fERN and P3) was associated with mood and inhibitory control. Consistent with the ERP findings, an analysis of source location revealed reduced responses of the cingulate cortex to the valence and magnitude of rewards in patients with ADHD and BD. Conclusions/Significance: Our data suggest that neurophysiological (ERPs) paradigms such as the RDGT are well suited to assess subclinical decision-making processes in patients with ADHD and BD as well as for linking the cingulate cortex with action monitoring systems. © 2012 Ibanez et al. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_19326203_v7_n5_p_Ibanez |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
adult anterior cingulate article attention deficit disorder behavior bipolar disorder clinical article controlled study decision making event related potential executive function feedback system female human hyperactivity impulsiveness Iowa Gambling Task learning disorder male mood disorder motivation neurobiology neurophysiology neuropsychological test rapid decision gambling task response time reward working memory analysis of variance biological model cingulate gyrus learning pathological gambling pathophysiology physiology reinforcement reward risk Filicophyta Adult Analysis of Variance Attention Deficit Disorder with Hyperactivity Bipolar Disorder Decision Making Gambling Gyrus Cinguli Humans Learning Models, Neurological Neuropsychological Tests Reinforcement (Psychology) Reward Risk |
| spellingShingle |
adult anterior cingulate article attention deficit disorder behavior bipolar disorder clinical article controlled study decision making event related potential executive function feedback system female human hyperactivity impulsiveness Iowa Gambling Task learning disorder male mood disorder motivation neurobiology neurophysiology neuropsychological test rapid decision gambling task response time reward working memory analysis of variance biological model cingulate gyrus learning pathological gambling pathophysiology physiology reinforcement reward risk Filicophyta Adult Analysis of Variance Attention Deficit Disorder with Hyperactivity Bipolar Disorder Decision Making Gambling Gyrus Cinguli Humans Learning Models, Neurological Neuropsychological Tests Reinforcement (Psychology) Reward Risk Ibanez, A. Cetkovich, M. Petroni, A. Urquina, H. Baez, S. Gonzalez-Gadea, M.L. Kamienkowski, J.E. Torralva, T. Torrente, F. Strejilevich, S. Teitelbaum, J. Hurtado, E. Guex, R. Melloni, M. Lischinsky, A. Sigman, M. Manes, F. The neural basis of decision-making and reward processing in adults with euthymic bipolar disorder or attention-deficit/hyperactivity disorder (ADHD) |
| topic_facet |
adult anterior cingulate article attention deficit disorder behavior bipolar disorder clinical article controlled study decision making event related potential executive function feedback system female human hyperactivity impulsiveness Iowa Gambling Task learning disorder male mood disorder motivation neurobiology neurophysiology neuropsychological test rapid decision gambling task response time reward working memory analysis of variance biological model cingulate gyrus learning pathological gambling pathophysiology physiology reinforcement reward risk Filicophyta Adult Analysis of Variance Attention Deficit Disorder with Hyperactivity Bipolar Disorder Decision Making Gambling Gyrus Cinguli Humans Learning Models, Neurological Neuropsychological Tests Reinforcement (Psychology) Reward Risk |
| description |
Background: Attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BD) share DSM-IV criteria in adults and cause problems in decision-making. Nevertheless, no previous report has assessed a decision-making task that includes the examination of the neural correlates of reward and gambling in adults with ADHD and those with BD. Methodology/Principal Findings: We used the Iowa gambling task (IGT), a task of rational decision-making under risk (RDMUR) and a rapid-decision gambling task (RDGT) which elicits behavioral measures as well as event-related potentials (ERPs: fERN and P3) in connection to the motivational impact of events. We did not observe between-group differences for decision-making under risk or ambiguity (RDMUR and IGT); however, there were significant differences for the ERP-assessed RDGT. Compared to controls, the ADHD group showed a pattern of impaired learning by feedback (fERN) and insensitivity to reward magnitude (P3). This ERP pattern (fERN and P3) was associated with impulsivity, hyperactivity, executive function and working memory. Compared to controls, the BD group showed fERN- and P3-enhanced responses to reward magnitude regardless of valence. This ERP pattern (fERN and P3) was associated with mood and inhibitory control. Consistent with the ERP findings, an analysis of source location revealed reduced responses of the cingulate cortex to the valence and magnitude of rewards in patients with ADHD and BD. Conclusions/Significance: Our data suggest that neurophysiological (ERPs) paradigms such as the RDGT are well suited to assess subclinical decision-making processes in patients with ADHD and BD as well as for linking the cingulate cortex with action monitoring systems. © 2012 Ibanez et al. |
| format |
JOUR |
| author |
Ibanez, A. Cetkovich, M. Petroni, A. Urquina, H. Baez, S. Gonzalez-Gadea, M.L. Kamienkowski, J.E. Torralva, T. Torrente, F. Strejilevich, S. Teitelbaum, J. Hurtado, E. Guex, R. Melloni, M. Lischinsky, A. Sigman, M. Manes, F. |
| author_facet |
Ibanez, A. Cetkovich, M. Petroni, A. Urquina, H. Baez, S. Gonzalez-Gadea, M.L. Kamienkowski, J.E. Torralva, T. Torrente, F. Strejilevich, S. Teitelbaum, J. Hurtado, E. Guex, R. Melloni, M. Lischinsky, A. Sigman, M. Manes, F. |
| author_sort |
Ibanez, A. |
| title |
The neural basis of decision-making and reward processing in adults with euthymic bipolar disorder or attention-deficit/hyperactivity disorder (ADHD) |
| title_short |
The neural basis of decision-making and reward processing in adults with euthymic bipolar disorder or attention-deficit/hyperactivity disorder (ADHD) |
| title_full |
The neural basis of decision-making and reward processing in adults with euthymic bipolar disorder or attention-deficit/hyperactivity disorder (ADHD) |
| title_fullStr |
The neural basis of decision-making and reward processing in adults with euthymic bipolar disorder or attention-deficit/hyperactivity disorder (ADHD) |
| title_full_unstemmed |
The neural basis of decision-making and reward processing in adults with euthymic bipolar disorder or attention-deficit/hyperactivity disorder (ADHD) |
| title_sort |
neural basis of decision-making and reward processing in adults with euthymic bipolar disorder or attention-deficit/hyperactivity disorder (adhd) |
| url |
http://hdl.handle.net/20.500.12110/paper_19326203_v7_n5_p_Ibanez |
| work_keys_str_mv |
AT ibaneza theneuralbasisofdecisionmakingandrewardprocessinginadultswitheuthymicbipolardisorderorattentiondeficithyperactivitydisorderadhd AT cetkovichm theneuralbasisofdecisionmakingandrewardprocessinginadultswitheuthymicbipolardisorderorattentiondeficithyperactivitydisorderadhd AT petronia theneuralbasisofdecisionmakingandrewardprocessinginadultswitheuthymicbipolardisorderorattentiondeficithyperactivitydisorderadhd AT urquinah theneuralbasisofdecisionmakingandrewardprocessinginadultswitheuthymicbipolardisorderorattentiondeficithyperactivitydisorderadhd AT baezs theneuralbasisofdecisionmakingandrewardprocessinginadultswitheuthymicbipolardisorderorattentiondeficithyperactivitydisorderadhd AT gonzalezgadeaml theneuralbasisofdecisionmakingandrewardprocessinginadultswitheuthymicbipolardisorderorattentiondeficithyperactivitydisorderadhd AT kamienkowskije theneuralbasisofdecisionmakingandrewardprocessinginadultswitheuthymicbipolardisorderorattentiondeficithyperactivitydisorderadhd AT torralvat theneuralbasisofdecisionmakingandrewardprocessinginadultswitheuthymicbipolardisorderorattentiondeficithyperactivitydisorderadhd AT torrentef theneuralbasisofdecisionmakingandrewardprocessinginadultswitheuthymicbipolardisorderorattentiondeficithyperactivitydisorderadhd AT strejilevichs theneuralbasisofdecisionmakingandrewardprocessinginadultswitheuthymicbipolardisorderorattentiondeficithyperactivitydisorderadhd AT teitelbaumj theneuralbasisofdecisionmakingandrewardprocessinginadultswitheuthymicbipolardisorderorattentiondeficithyperactivitydisorderadhd AT hurtadoe theneuralbasisofdecisionmakingandrewardprocessinginadultswitheuthymicbipolardisorderorattentiondeficithyperactivitydisorderadhd AT guexr theneuralbasisofdecisionmakingandrewardprocessinginadultswitheuthymicbipolardisorderorattentiondeficithyperactivitydisorderadhd AT mellonim theneuralbasisofdecisionmakingandrewardprocessinginadultswitheuthymicbipolardisorderorattentiondeficithyperactivitydisorderadhd AT lischinskya theneuralbasisofdecisionmakingandrewardprocessinginadultswitheuthymicbipolardisorderorattentiondeficithyperactivitydisorderadhd AT sigmanm theneuralbasisofdecisionmakingandrewardprocessinginadultswitheuthymicbipolardisorderorattentiondeficithyperactivitydisorderadhd AT manesf theneuralbasisofdecisionmakingandrewardprocessinginadultswitheuthymicbipolardisorderorattentiondeficithyperactivitydisorderadhd AT ibaneza neuralbasisofdecisionmakingandrewardprocessinginadultswitheuthymicbipolardisorderorattentiondeficithyperactivitydisorderadhd AT cetkovichm neuralbasisofdecisionmakingandrewardprocessinginadultswitheuthymicbipolardisorderorattentiondeficithyperactivitydisorderadhd AT petronia neuralbasisofdecisionmakingandrewardprocessinginadultswitheuthymicbipolardisorderorattentiondeficithyperactivitydisorderadhd AT urquinah neuralbasisofdecisionmakingandrewardprocessinginadultswitheuthymicbipolardisorderorattentiondeficithyperactivitydisorderadhd AT baezs neuralbasisofdecisionmakingandrewardprocessinginadultswitheuthymicbipolardisorderorattentiondeficithyperactivitydisorderadhd AT gonzalezgadeaml neuralbasisofdecisionmakingandrewardprocessinginadultswitheuthymicbipolardisorderorattentiondeficithyperactivitydisorderadhd AT kamienkowskije neuralbasisofdecisionmakingandrewardprocessinginadultswitheuthymicbipolardisorderorattentiondeficithyperactivitydisorderadhd AT torralvat neuralbasisofdecisionmakingandrewardprocessinginadultswitheuthymicbipolardisorderorattentiondeficithyperactivitydisorderadhd AT torrentef neuralbasisofdecisionmakingandrewardprocessinginadultswitheuthymicbipolardisorderorattentiondeficithyperactivitydisorderadhd AT strejilevichs neuralbasisofdecisionmakingandrewardprocessinginadultswitheuthymicbipolardisorderorattentiondeficithyperactivitydisorderadhd AT teitelbaumj neuralbasisofdecisionmakingandrewardprocessinginadultswitheuthymicbipolardisorderorattentiondeficithyperactivitydisorderadhd AT hurtadoe neuralbasisofdecisionmakingandrewardprocessinginadultswitheuthymicbipolardisorderorattentiondeficithyperactivitydisorderadhd AT guexr neuralbasisofdecisionmakingandrewardprocessinginadultswitheuthymicbipolardisorderorattentiondeficithyperactivitydisorderadhd AT mellonim neuralbasisofdecisionmakingandrewardprocessinginadultswitheuthymicbipolardisorderorattentiondeficithyperactivitydisorderadhd AT lischinskya neuralbasisofdecisionmakingandrewardprocessinginadultswitheuthymicbipolardisorderorattentiondeficithyperactivitydisorderadhd AT sigmanm neuralbasisofdecisionmakingandrewardprocessinginadultswitheuthymicbipolardisorderorattentiondeficithyperactivitydisorderadhd AT manesf neuralbasisofdecisionmakingandrewardprocessinginadultswitheuthymicbipolardisorderorattentiondeficithyperactivitydisorderadhd |
| _version_ |
1782024321213923328 |