Neural Processing of Emotional Facial and Semantic Expressions in Euthymic Bipolar Disorder (BD) and Its Association with Theory of Mind (ToM)
Background: Adults with bipolar disorder (BD) have cognitive impairments that affect face processing and social cognition. However, it remains unknown whether these deficits in euthymic BD have impaired brain markers of emotional processing. Methodology/Principal Findings: We recruited twenty six pa...
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todo:paper_19326203_v7_n10_p_Ibanez2023-10-03T16:35:13Z Neural Processing of Emotional Facial and Semantic Expressions in Euthymic Bipolar Disorder (BD) and Its Association with Theory of Mind (ToM) Ibanez, A. Urquina, H. Petroni, A. Baez, S. Lopez, V. do Nascimento, M. Herrera, E. Guex, R. Hurtado, E. Blenkmann, A. Beltrachini, L. Gelormini, C. Sigman, M. Lischinsky, A. Torralva, T. Torrente, F. Cetkovich, M. Manes, F. adult anger article bipolar disorder clinical article controlled study depression dual valence task emotion event related potential facial expression female fusiform face area fusiform gyrus happiness human impulsiveness male mania neuropsychological test questionnaire right handedness semantic memory social cognition State Trait Anxiety Inventory stimulus response task performance theory of mind Acoustic Stimulation Adult Behavior Bipolar Disorder Emotions Evoked Potentials Facial Expression Female Humans Male Neuropsychological Tests Photic Stimulation Recognition (Psychology) Semantics Theory of Mind Background: Adults with bipolar disorder (BD) have cognitive impairments that affect face processing and social cognition. However, it remains unknown whether these deficits in euthymic BD have impaired brain markers of emotional processing. Methodology/Principal Findings: We recruited twenty six participants, 13 controls subjects with an equal number of euthymic BD participants. We used an event-related potential (ERP) assessment of a dual valence task (DVT), in which faces (angry and happy), words (pleasant and unpleasant), and face-word simultaneous combinations are presented to test the effects of the stimulus type (face vs word) and valence (positive vs. negative). All participants received clinical, neuropsychological and social cognition evaluations. ERP analysis revealed that both groups showed N170 modulation of stimulus type effects (face > word). BD patients exhibited reduced and enhanced N170 to facial and semantic valence, respectively. The neural source estimation of N170 was a posterior section of the fusiform gyrus (FG), including the face fusiform area (FFA). Neural generators of N170 for faces (FG and FFA) were reduced in BD. In these patients, N170 modulation was associated with social cognition (theory of mind). Conclusions/Significance: This is the first report of euthymic BD exhibiting abnormal N170 emotional discrimination associated with theory of mind impairments. © 2012 Ibanez et al. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_19326203_v7_n10_p_Ibanez |
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Universidad de Buenos Aires |
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I-28 |
| repository_str |
R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
adult anger article bipolar disorder clinical article controlled study depression dual valence task emotion event related potential facial expression female fusiform face area fusiform gyrus happiness human impulsiveness male mania neuropsychological test questionnaire right handedness semantic memory social cognition State Trait Anxiety Inventory stimulus response task performance theory of mind Acoustic Stimulation Adult Behavior Bipolar Disorder Emotions Evoked Potentials Facial Expression Female Humans Male Neuropsychological Tests Photic Stimulation Recognition (Psychology) Semantics Theory of Mind |
| spellingShingle |
adult anger article bipolar disorder clinical article controlled study depression dual valence task emotion event related potential facial expression female fusiform face area fusiform gyrus happiness human impulsiveness male mania neuropsychological test questionnaire right handedness semantic memory social cognition State Trait Anxiety Inventory stimulus response task performance theory of mind Acoustic Stimulation Adult Behavior Bipolar Disorder Emotions Evoked Potentials Facial Expression Female Humans Male Neuropsychological Tests Photic Stimulation Recognition (Psychology) Semantics Theory of Mind Ibanez, A. Urquina, H. Petroni, A. Baez, S. Lopez, V. do Nascimento, M. Herrera, E. Guex, R. Hurtado, E. Blenkmann, A. Beltrachini, L. Gelormini, C. Sigman, M. Lischinsky, A. Torralva, T. Torrente, F. Cetkovich, M. Manes, F. Neural Processing of Emotional Facial and Semantic Expressions in Euthymic Bipolar Disorder (BD) and Its Association with Theory of Mind (ToM) |
| topic_facet |
adult anger article bipolar disorder clinical article controlled study depression dual valence task emotion event related potential facial expression female fusiform face area fusiform gyrus happiness human impulsiveness male mania neuropsychological test questionnaire right handedness semantic memory social cognition State Trait Anxiety Inventory stimulus response task performance theory of mind Acoustic Stimulation Adult Behavior Bipolar Disorder Emotions Evoked Potentials Facial Expression Female Humans Male Neuropsychological Tests Photic Stimulation Recognition (Psychology) Semantics Theory of Mind |
| description |
Background: Adults with bipolar disorder (BD) have cognitive impairments that affect face processing and social cognition. However, it remains unknown whether these deficits in euthymic BD have impaired brain markers of emotional processing. Methodology/Principal Findings: We recruited twenty six participants, 13 controls subjects with an equal number of euthymic BD participants. We used an event-related potential (ERP) assessment of a dual valence task (DVT), in which faces (angry and happy), words (pleasant and unpleasant), and face-word simultaneous combinations are presented to test the effects of the stimulus type (face vs word) and valence (positive vs. negative). All participants received clinical, neuropsychological and social cognition evaluations. ERP analysis revealed that both groups showed N170 modulation of stimulus type effects (face > word). BD patients exhibited reduced and enhanced N170 to facial and semantic valence, respectively. The neural source estimation of N170 was a posterior section of the fusiform gyrus (FG), including the face fusiform area (FFA). Neural generators of N170 for faces (FG and FFA) were reduced in BD. In these patients, N170 modulation was associated with social cognition (theory of mind). Conclusions/Significance: This is the first report of euthymic BD exhibiting abnormal N170 emotional discrimination associated with theory of mind impairments. © 2012 Ibanez et al. |
| format |
JOUR |
| author |
Ibanez, A. Urquina, H. Petroni, A. Baez, S. Lopez, V. do Nascimento, M. Herrera, E. Guex, R. Hurtado, E. Blenkmann, A. Beltrachini, L. Gelormini, C. Sigman, M. Lischinsky, A. Torralva, T. Torrente, F. Cetkovich, M. Manes, F. |
| author_facet |
Ibanez, A. Urquina, H. Petroni, A. Baez, S. Lopez, V. do Nascimento, M. Herrera, E. Guex, R. Hurtado, E. Blenkmann, A. Beltrachini, L. Gelormini, C. Sigman, M. Lischinsky, A. Torralva, T. Torrente, F. Cetkovich, M. Manes, F. |
| author_sort |
Ibanez, A. |
| title |
Neural Processing of Emotional Facial and Semantic Expressions in Euthymic Bipolar Disorder (BD) and Its Association with Theory of Mind (ToM) |
| title_short |
Neural Processing of Emotional Facial and Semantic Expressions in Euthymic Bipolar Disorder (BD) and Its Association with Theory of Mind (ToM) |
| title_full |
Neural Processing of Emotional Facial and Semantic Expressions in Euthymic Bipolar Disorder (BD) and Its Association with Theory of Mind (ToM) |
| title_fullStr |
Neural Processing of Emotional Facial and Semantic Expressions in Euthymic Bipolar Disorder (BD) and Its Association with Theory of Mind (ToM) |
| title_full_unstemmed |
Neural Processing of Emotional Facial and Semantic Expressions in Euthymic Bipolar Disorder (BD) and Its Association with Theory of Mind (ToM) |
| title_sort |
neural processing of emotional facial and semantic expressions in euthymic bipolar disorder (bd) and its association with theory of mind (tom) |
| url |
http://hdl.handle.net/20.500.12110/paper_19326203_v7_n10_p_Ibanez |
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