Isolation of three new ent-labdane diterpenes from Dodonaea viscosa Jacquin (Sapindaceae): Preliminary evaluation of antiherpes activity

Investigation of the crude ethanolic extract obtained from the aerial parts of Dodonaea viscosa led to the isolation of three new ent-labdane diterpenes (1-3). The structures were established on the basis of their ESI-MS, UV, IR and NMR spectral data. The crude extract, fractions and compounds were...

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Autores principales:	Oliveira, S.Q.D., Almeida, M.T.R.D., Maraslis, F., Silva, I.T., Sincero, T.C.M., Palermo, J.A., Cabrera, G.M., Caro, M.S.B., Simões, C.M.O., Schenkel, E.P.
Formato:	JOUR
Materias:	Antiherpes Diterpenes Dodonaea viscosa ent-Labdanes HSV-1 Sapindaceae 8beta hydroxy 3 o beta dextro glucopyranosyl ent labda 13 en 15,16 diol antivirus agent diterpene ent 15epsilon ethoxylabdan 3alpha,8beta dihydroxy 13(14) en 15,16 olide ent 16epsilon hydroxylabdan 3alpha,8beta dihydroxy 13(14) en 15,16 olide plant extract unclassified drug antiviral activity article carbon nuclear magnetic resonance drug mechanism drug structure electrospray mass spectrometry Herpes simplex virus 1 heteronuclear multiple bond correlation heteronuclear single quantum coherence IC 50 infrared spectroscopy nonhuman nuclear Overhauser effect priority journal proton nuclear magnetic resonance ultraviolet spectroscopy Human herpesvirus 1
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_18743900_v5_n3_p500_Oliveira
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_18743900_v5_n3_p500_Oliveira
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spelling	todo:paper_18743900_v5_n3_p500_Oliveira2023-10-03T16:34:05Z Isolation of three new ent-labdane diterpenes from Dodonaea viscosa Jacquin (Sapindaceae): Preliminary evaluation of antiherpes activity Oliveira, S.Q.D. Almeida, M.T.R.D. Maraslis, F. Silva, I.T. Sincero, T.C.M. Palermo, J.A. Cabrera, G.M. Caro, M.S.B. Simões, C.M.O. Schenkel, E.P. Antiherpes Diterpenes Dodonaea viscosa ent-Labdanes HSV-1 Sapindaceae 8beta hydroxy 3 o beta dextro glucopyranosyl ent labda 13 en 15,16 diol antivirus agent diterpene ent 15epsilon ethoxylabdan 3alpha,8beta dihydroxy 13(14) en 15,16 olide ent 16epsilon hydroxylabdan 3alpha,8beta dihydroxy 13(14) en 15,16 olide plant extract unclassified drug antiviral activity article carbon nuclear magnetic resonance Dodonaea viscosa drug mechanism drug structure electrospray mass spectrometry Herpes simplex virus 1 heteronuclear multiple bond correlation heteronuclear single quantum coherence IC 50 infrared spectroscopy nonhuman nuclear Overhauser effect priority journal proton nuclear magnetic resonance ultraviolet spectroscopy Dodonaea viscosa Human herpesvirus 1 Sapindaceae Investigation of the crude ethanolic extract obtained from the aerial parts of Dodonaea viscosa led to the isolation of three new ent-labdane diterpenes (1-3). The structures were established on the basis of their ESI-MS, UV, IR and NMR spectral data. The crude extract, fractions and compounds were evaluated for in vitro antiviral activity against Herpes Simplex Virus type 1 (HSV-1). The crude extract showed promising antiherpes activity expressed by a selectivity index of 6.2. © 2012 Phytochemical Society of Europe. Fil:Palermo, J.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Cabrera, G.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_18743900_v5_n3_p500_Oliveira
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Antiherpes Diterpenes Dodonaea viscosa ent-Labdanes HSV-1 Sapindaceae 8beta hydroxy 3 o beta dextro glucopyranosyl ent labda 13 en 15,16 diol antivirus agent diterpene ent 15epsilon ethoxylabdan 3alpha,8beta dihydroxy 13(14) en 15,16 olide ent 16epsilon hydroxylabdan 3alpha,8beta dihydroxy 13(14) en 15,16 olide plant extract unclassified drug antiviral activity article carbon nuclear magnetic resonance Dodonaea viscosa drug mechanism drug structure electrospray mass spectrometry Herpes simplex virus 1 heteronuclear multiple bond correlation heteronuclear single quantum coherence IC 50 infrared spectroscopy nonhuman nuclear Overhauser effect priority journal proton nuclear magnetic resonance ultraviolet spectroscopy Dodonaea viscosa Human herpesvirus 1 Sapindaceae
spellingShingle	Antiherpes Diterpenes Dodonaea viscosa ent-Labdanes HSV-1 Sapindaceae 8beta hydroxy 3 o beta dextro glucopyranosyl ent labda 13 en 15,16 diol antivirus agent diterpene ent 15epsilon ethoxylabdan 3alpha,8beta dihydroxy 13(14) en 15,16 olide ent 16epsilon hydroxylabdan 3alpha,8beta dihydroxy 13(14) en 15,16 olide plant extract unclassified drug antiviral activity article carbon nuclear magnetic resonance Dodonaea viscosa drug mechanism drug structure electrospray mass spectrometry Herpes simplex virus 1 heteronuclear multiple bond correlation heteronuclear single quantum coherence IC 50 infrared spectroscopy nonhuman nuclear Overhauser effect priority journal proton nuclear magnetic resonance ultraviolet spectroscopy Dodonaea viscosa Human herpesvirus 1 Sapindaceae Oliveira, S.Q.D. Almeida, M.T.R.D. Maraslis, F. Silva, I.T. Sincero, T.C.M. Palermo, J.A. Cabrera, G.M. Caro, M.S.B. Simões, C.M.O. Schenkel, E.P. Isolation of three new ent-labdane diterpenes from Dodonaea viscosa Jacquin (Sapindaceae): Preliminary evaluation of antiherpes activity
topic_facet	Antiherpes Diterpenes Dodonaea viscosa ent-Labdanes HSV-1 Sapindaceae 8beta hydroxy 3 o beta dextro glucopyranosyl ent labda 13 en 15,16 diol antivirus agent diterpene ent 15epsilon ethoxylabdan 3alpha,8beta dihydroxy 13(14) en 15,16 olide ent 16epsilon hydroxylabdan 3alpha,8beta dihydroxy 13(14) en 15,16 olide plant extract unclassified drug antiviral activity article carbon nuclear magnetic resonance Dodonaea viscosa drug mechanism drug structure electrospray mass spectrometry Herpes simplex virus 1 heteronuclear multiple bond correlation heteronuclear single quantum coherence IC 50 infrared spectroscopy nonhuman nuclear Overhauser effect priority journal proton nuclear magnetic resonance ultraviolet spectroscopy Dodonaea viscosa Human herpesvirus 1 Sapindaceae
description	Investigation of the crude ethanolic extract obtained from the aerial parts of Dodonaea viscosa led to the isolation of three new ent-labdane diterpenes (1-3). The structures were established on the basis of their ESI-MS, UV, IR and NMR spectral data. The crude extract, fractions and compounds were evaluated for in vitro antiviral activity against Herpes Simplex Virus type 1 (HSV-1). The crude extract showed promising antiherpes activity expressed by a selectivity index of 6.2. © 2012 Phytochemical Society of Europe.
format	JOUR
author	Oliveira, S.Q.D. Almeida, M.T.R.D. Maraslis, F. Silva, I.T. Sincero, T.C.M. Palermo, J.A. Cabrera, G.M. Caro, M.S.B. Simões, C.M.O. Schenkel, E.P.
author_facet	Oliveira, S.Q.D. Almeida, M.T.R.D. Maraslis, F. Silva, I.T. Sincero, T.C.M. Palermo, J.A. Cabrera, G.M. Caro, M.S.B. Simões, C.M.O. Schenkel, E.P.
author_sort	Oliveira, S.Q.D.
title	Isolation of three new ent-labdane diterpenes from Dodonaea viscosa Jacquin (Sapindaceae): Preliminary evaluation of antiherpes activity
title_short	Isolation of three new ent-labdane diterpenes from Dodonaea viscosa Jacquin (Sapindaceae): Preliminary evaluation of antiherpes activity
title_full	Isolation of three new ent-labdane diterpenes from Dodonaea viscosa Jacquin (Sapindaceae): Preliminary evaluation of antiherpes activity
title_fullStr	Isolation of three new ent-labdane diterpenes from Dodonaea viscosa Jacquin (Sapindaceae): Preliminary evaluation of antiherpes activity
title_full_unstemmed	Isolation of three new ent-labdane diterpenes from Dodonaea viscosa Jacquin (Sapindaceae): Preliminary evaluation of antiherpes activity
title_sort	isolation of three new ent-labdane diterpenes from dodonaea viscosa jacquin (sapindaceae): preliminary evaluation of antiherpes activity
url	http://hdl.handle.net/20.500.12110/paper_18743900_v5_n3_p500_Oliveira
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Isolation of three new ent-labdane diterpenes from Dodonaea viscosa Jacquin (Sapindaceae): Preliminary evaluation of antiherpes activity

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