Mice Brain nitric oxide synthase response induced by anaesthetics and other porphyrinogenic drugs

Porphyrias neuropathophysiology could be related to low levels of heme as a cofactor for nitric oxide synthase (NOS). We examined how anaesthetics and other porphyrinogenic agents affect mice NOS activity and expression. Brain response was differential depending on the cellular fraction analyzed. Mo...

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Autores principales:	Lavandera, J., Batlle, A., Buzaleh, A.M.
Formato:	JOUR
Materias:	Anaesthetics Brain Nitric oxide synthase Porphyric neuropathy Porphyrinogenic agent alcohol allylisopropylacetamide barbital enflurane griseofulvin inducible nitric oxide synthase isoflurane neuronal nitric oxide synthase nitric oxide synthase porphyrinogen animal experiment animal tissue article brain function cell fractionation comparative study controlled study enzyme activity liver metabolism male mouse nonhuman outcome assessment priority journal protein expression single drug dose starvation Western blotting Anesthetics Animals Cell Fractionation Cytosol Enzyme Induction Liver Male Mice Mitochondria Nitric Oxide Synthase Porphyrias Mus
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_18723128_v5_n1_p25_Lavandera
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_18723128_v5_n1_p25_Lavandera
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spelling	todo:paper_18723128_v5_n1_p25_Lavandera2023-10-03T16:33:59Z Mice Brain nitric oxide synthase response induced by anaesthetics and other porphyrinogenic drugs Lavandera, J. Batlle, A. Buzaleh, A.M. Anaesthetics Brain Nitric oxide synthase Porphyric neuropathy Porphyrinogenic agent alcohol allylisopropylacetamide barbital enflurane griseofulvin inducible nitric oxide synthase isoflurane neuronal nitric oxide synthase nitric oxide synthase porphyrinogen animal experiment animal tissue article brain function cell fractionation comparative study controlled study enzyme activity liver metabolism male mouse nonhuman outcome assessment priority journal protein expression single drug dose starvation Western blotting Anesthetics Animals Brain Cell Fractionation Cytosol Enzyme Induction Liver Male Mice Mitochondria Nitric Oxide Synthase Porphyrias Mus Porphyrias neuropathophysiology could be related to low levels of heme as a cofactor for nitric oxide synthase (NOS). We examined how anaesthetics and other porphyrinogenic agents affect mice NOS activity and expression. Brain response was differential depending on the cellular fraction analyzed. Most of the drugs diminished cytosolic activity. Instead, isoflurane, enflurane and ethanol increased mitochondrial activity. NOS expression also depended on the drug tested. A comparative study was performed in liver. Our present and previous results indicate the widespread action of porphyrinogenic agents in brain, which could be the reason why it is difficult to establish the onset of acute porphyria neurological manifestations. © 2011 Bentham Science Publishers Ltd. Fil:Lavandera, J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Batlle, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Buzaleh, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_18723128_v5_n1_p25_Lavandera
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Anaesthetics Brain Nitric oxide synthase Porphyric neuropathy Porphyrinogenic agent alcohol allylisopropylacetamide barbital enflurane griseofulvin inducible nitric oxide synthase isoflurane neuronal nitric oxide synthase nitric oxide synthase porphyrinogen animal experiment animal tissue article brain function cell fractionation comparative study controlled study enzyme activity liver metabolism male mouse nonhuman outcome assessment priority journal protein expression single drug dose starvation Western blotting Anesthetics Animals Brain Cell Fractionation Cytosol Enzyme Induction Liver Male Mice Mitochondria Nitric Oxide Synthase Porphyrias Mus
spellingShingle	Anaesthetics Brain Nitric oxide synthase Porphyric neuropathy Porphyrinogenic agent alcohol allylisopropylacetamide barbital enflurane griseofulvin inducible nitric oxide synthase isoflurane neuronal nitric oxide synthase nitric oxide synthase porphyrinogen animal experiment animal tissue article brain function cell fractionation comparative study controlled study enzyme activity liver metabolism male mouse nonhuman outcome assessment priority journal protein expression single drug dose starvation Western blotting Anesthetics Animals Brain Cell Fractionation Cytosol Enzyme Induction Liver Male Mice Mitochondria Nitric Oxide Synthase Porphyrias Mus Lavandera, J. Batlle, A. Buzaleh, A.M. Mice Brain nitric oxide synthase response induced by anaesthetics and other porphyrinogenic drugs
topic_facet	Anaesthetics Brain Nitric oxide synthase Porphyric neuropathy Porphyrinogenic agent alcohol allylisopropylacetamide barbital enflurane griseofulvin inducible nitric oxide synthase isoflurane neuronal nitric oxide synthase nitric oxide synthase porphyrinogen animal experiment animal tissue article brain function cell fractionation comparative study controlled study enzyme activity liver metabolism male mouse nonhuman outcome assessment priority journal protein expression single drug dose starvation Western blotting Anesthetics Animals Brain Cell Fractionation Cytosol Enzyme Induction Liver Male Mice Mitochondria Nitric Oxide Synthase Porphyrias Mus
description	Porphyrias neuropathophysiology could be related to low levels of heme as a cofactor for nitric oxide synthase (NOS). We examined how anaesthetics and other porphyrinogenic agents affect mice NOS activity and expression. Brain response was differential depending on the cellular fraction analyzed. Most of the drugs diminished cytosolic activity. Instead, isoflurane, enflurane and ethanol increased mitochondrial activity. NOS expression also depended on the drug tested. A comparative study was performed in liver. Our present and previous results indicate the widespread action of porphyrinogenic agents in brain, which could be the reason why it is difficult to establish the onset of acute porphyria neurological manifestations. © 2011 Bentham Science Publishers Ltd.
format	JOUR
author	Lavandera, J. Batlle, A. Buzaleh, A.M.
author_facet	Lavandera, J. Batlle, A. Buzaleh, A.M.
author_sort	Lavandera, J.
title	Mice Brain nitric oxide synthase response induced by anaesthetics and other porphyrinogenic drugs
title_short	Mice Brain nitric oxide synthase response induced by anaesthetics and other porphyrinogenic drugs
title_full	Mice Brain nitric oxide synthase response induced by anaesthetics and other porphyrinogenic drugs
title_fullStr	Mice Brain nitric oxide synthase response induced by anaesthetics and other porphyrinogenic drugs
title_full_unstemmed	Mice Brain nitric oxide synthase response induced by anaesthetics and other porphyrinogenic drugs
title_sort	mice brain nitric oxide synthase response induced by anaesthetics and other porphyrinogenic drugs
url	http://hdl.handle.net/20.500.12110/paper_18723128_v5_n1_p25_Lavandera
work_keys_str_mv	AT lavanderaj micebrainnitricoxidesynthaseresponseinducedbyanaestheticsandotherporphyrinogenicdrugs AT batllea micebrainnitricoxidesynthaseresponseinducedbyanaestheticsandotherporphyrinogenicdrugs AT buzaleham micebrainnitricoxidesynthaseresponseinducedbyanaestheticsandotherporphyrinogenicdrugs
_version_	1782029603674521600

Mice Brain nitric oxide synthase response induced by anaesthetics and other porphyrinogenic drugs

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