Adiponectin and waist circumference as predictors of insulin-resistance in women
Background and aims: The initial disturbance of insulin resistance seems to focus on adipose tissue is a dynamic organ involved in many physiological and metabolic processes. Expresses and secretes a variety of active peptides, adipocytokines. To evaluate the prevalence of insulin-resistance in an h...
Guardado en:
| Autores principales: | , , |
|---|---|
| Formato: | INPR |
| Lenguaje: | English |
| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_18714021_v_n_p_Bonneau |
| Aporte de: |
| id |
todo:paper_18714021_v_n_p_Bonneau |
|---|---|
| record_format |
dspace |
| spelling |
todo:paper_18714021_v_n_p_Bonneau2023-10-03T16:33:56Z Adiponectin and waist circumference as predictors of insulin-resistance in women Bonneau, G.A. Pedrozo, W.R. Berg, G. Abdominal obesity Adiponectin Female gender Insulin-resistance Post-menopause Background and aims: The initial disturbance of insulin resistance seems to focus on adipose tissue is a dynamic organ involved in many physiological and metabolic processes. Expresses and secretes a variety of active peptides, adipocytokines. To evaluate the prevalence of insulin-resistance in an healthy urban middle age population and to explore the role of adiponectin, inflammatory biomarkers (hs-CRP) and traditional cardiovascular risk factors as predictors of the insulin-resistance state. Materials and methods: We studied of 176 participants (117 women and 59 men, 25-74 years), individuals with diabetes, hypothyroidism or hyperthyroidism, infectious disease, renal, or hepatic neoplasms and pregnant women were excluded. We evaluated glucose, insulin, adiponectin and hs-CRP. Results: We found that 17.2% of individuals presented insulin-resistance. Correlation was found between waist circumference, body mass index, blood pressure and HOMA index (p < 0.01). Adiponectin was associated with the insulin-resistance (p < 0.001) but not hs-CRP. Adiponectin (β = 0.385, p = 0.004) and waist circumference (β = 0.116, p = 0.02) were predictors of IR only in women, meanwhile none of the analyzed biomarkers predicted insulin-resistance in men. Besides, postmenopausal women presented higher adiponectin levels than premenopausal 7.63 (4.46-9.58) vs 5.50 (3.83-7.40) μg/ml, p = 0.01. Conclusions: Adiponectin and waist circumference are important predictors of insulin-resistance even in healthy non-diabetic women, they may open a new opportunity to improve current risk estimation. © 2013 Diabetes India. INPR English info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_18714021_v_n_p_Bonneau |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| language |
English |
| orig_language_str_mv |
English |
| topic |
Abdominal obesity Adiponectin Female gender Insulin-resistance Post-menopause |
| spellingShingle |
Abdominal obesity Adiponectin Female gender Insulin-resistance Post-menopause Bonneau, G.A. Pedrozo, W.R. Berg, G. Adiponectin and waist circumference as predictors of insulin-resistance in women |
| topic_facet |
Abdominal obesity Adiponectin Female gender Insulin-resistance Post-menopause |
| description |
Background and aims: The initial disturbance of insulin resistance seems to focus on adipose tissue is a dynamic organ involved in many physiological and metabolic processes. Expresses and secretes a variety of active peptides, adipocytokines. To evaluate the prevalence of insulin-resistance in an healthy urban middle age population and to explore the role of adiponectin, inflammatory biomarkers (hs-CRP) and traditional cardiovascular risk factors as predictors of the insulin-resistance state. Materials and methods: We studied of 176 participants (117 women and 59 men, 25-74 years), individuals with diabetes, hypothyroidism or hyperthyroidism, infectious disease, renal, or hepatic neoplasms and pregnant women were excluded. We evaluated glucose, insulin, adiponectin and hs-CRP. Results: We found that 17.2% of individuals presented insulin-resistance. Correlation was found between waist circumference, body mass index, blood pressure and HOMA index (p < 0.01). Adiponectin was associated with the insulin-resistance (p < 0.001) but not hs-CRP. Adiponectin (β = 0.385, p = 0.004) and waist circumference (β = 0.116, p = 0.02) were predictors of IR only in women, meanwhile none of the analyzed biomarkers predicted insulin-resistance in men. Besides, postmenopausal women presented higher adiponectin levels than premenopausal 7.63 (4.46-9.58) vs 5.50 (3.83-7.40) μg/ml, p = 0.01. Conclusions: Adiponectin and waist circumference are important predictors of insulin-resistance even in healthy non-diabetic women, they may open a new opportunity to improve current risk estimation. © 2013 Diabetes India. |
| format |
INPR |
| author |
Bonneau, G.A. Pedrozo, W.R. Berg, G. |
| author_facet |
Bonneau, G.A. Pedrozo, W.R. Berg, G. |
| author_sort |
Bonneau, G.A. |
| title |
Adiponectin and waist circumference as predictors of insulin-resistance in women |
| title_short |
Adiponectin and waist circumference as predictors of insulin-resistance in women |
| title_full |
Adiponectin and waist circumference as predictors of insulin-resistance in women |
| title_fullStr |
Adiponectin and waist circumference as predictors of insulin-resistance in women |
| title_full_unstemmed |
Adiponectin and waist circumference as predictors of insulin-resistance in women |
| title_sort |
adiponectin and waist circumference as predictors of insulin-resistance in women |
| url |
http://hdl.handle.net/20.500.12110/paper_18714021_v_n_p_Bonneau |
| work_keys_str_mv |
AT bonneauga adiponectinandwaistcircumferenceaspredictorsofinsulinresistanceinwomen AT pedrozowr adiponectinandwaistcircumferenceaspredictorsofinsulinresistanceinwomen AT bergg adiponectinandwaistcircumferenceaspredictorsofinsulinresistanceinwomen |
| _version_ |
1807316576268976128 |