The Role of the Phosphorus Atom in Drug Design
Although the phosphorus atom is found in a variety of oxidation states, most of the phosphorus-containing molecules of pharmacological importance possess phosphorus in the form of phosphonate or phosphinate functional groups, or in a major oxidation state as a phosphate group. The most common occurr...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_18607179_v14_n2_p190_Rodriguez |
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todo:paper_18607179_v14_n2_p190_Rodriguez2023-10-03T16:33:20Z The Role of the Phosphorus Atom in Drug Design Rodriguez, J.B. Gallo-Rodriguez, C. bisphosphonates nucleotides organophosphorus compounds phosphorus prodrugs bisphosphonic acid derivative geranyltransferase heterocyclic compound miscellaneous drugs and agents nucleotide phosphorus derivative prodrug squalene synthase atom drug conjugation drug design drug structure drug targeting human molecular weight nonhuman priority journal Review Although the phosphorus atom is found in a variety of oxidation states, most of the phosphorus-containing molecules of pharmacological importance possess phosphorus in the form of phosphonate or phosphinate functional groups, or in a major oxidation state as a phosphate group. The most common occurrence of phosphorus in drugs is either in prodrugs or in compounds for which the phosphorus atom plays a role in the biological activity, such as in modified nucleotides, in metabolically stable analogues of metabolites bearing phosphate groups, and as bioisosteric analogues of carboxyl groups. © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_18607179_v14_n2_p190_Rodriguez |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
bisphosphonates nucleotides organophosphorus compounds phosphorus prodrugs bisphosphonic acid derivative geranyltransferase heterocyclic compound miscellaneous drugs and agents nucleotide phosphorus derivative prodrug squalene synthase atom drug conjugation drug design drug structure drug targeting human molecular weight nonhuman priority journal Review |
| spellingShingle |
bisphosphonates nucleotides organophosphorus compounds phosphorus prodrugs bisphosphonic acid derivative geranyltransferase heterocyclic compound miscellaneous drugs and agents nucleotide phosphorus derivative prodrug squalene synthase atom drug conjugation drug design drug structure drug targeting human molecular weight nonhuman priority journal Review Rodriguez, J.B. Gallo-Rodriguez, C. The Role of the Phosphorus Atom in Drug Design |
| topic_facet |
bisphosphonates nucleotides organophosphorus compounds phosphorus prodrugs bisphosphonic acid derivative geranyltransferase heterocyclic compound miscellaneous drugs and agents nucleotide phosphorus derivative prodrug squalene synthase atom drug conjugation drug design drug structure drug targeting human molecular weight nonhuman priority journal Review |
| description |
Although the phosphorus atom is found in a variety of oxidation states, most of the phosphorus-containing molecules of pharmacological importance possess phosphorus in the form of phosphonate or phosphinate functional groups, or in a major oxidation state as a phosphate group. The most common occurrence of phosphorus in drugs is either in prodrugs or in compounds for which the phosphorus atom plays a role in the biological activity, such as in modified nucleotides, in metabolically stable analogues of metabolites bearing phosphate groups, and as bioisosteric analogues of carboxyl groups. © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim |
| format |
JOUR |
| author |
Rodriguez, J.B. Gallo-Rodriguez, C. |
| author_facet |
Rodriguez, J.B. Gallo-Rodriguez, C. |
| author_sort |
Rodriguez, J.B. |
| title |
The Role of the Phosphorus Atom in Drug Design |
| title_short |
The Role of the Phosphorus Atom in Drug Design |
| title_full |
The Role of the Phosphorus Atom in Drug Design |
| title_fullStr |
The Role of the Phosphorus Atom in Drug Design |
| title_full_unstemmed |
The Role of the Phosphorus Atom in Drug Design |
| title_sort |
role of the phosphorus atom in drug design |
| url |
http://hdl.handle.net/20.500.12110/paper_18607179_v14_n2_p190_Rodriguez |
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| _version_ |
1807315826735316992 |