Toward biomedical application of amino-functionalized silicon nanoparticles

Silicon blue-emitting nanoparticles (NPs) are promising effectors for photodynamic therapy and radiotherapy, because of their production of reactive oxygen species (ROS) upon irradiation. Results: Amino-functionalized silicon NPs (NH2SiNP) were intrinsically nontoxic below 100 μg/ml in vitro (on two...

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Detalles Bibliográficos
Autores principales:	Lillo, C.R., Natalia Calienni, M., Gorojod, R.M., Rivas Aiello, M.B., Rodriguez Sartori, D., Prieto, M.J., Alonso, S.D.V., Kotler, M.L., Gonzalez, M.C., Montanari, J.
Formato:	JOUR
Materias:	PDT radiotherapy silicon nanoparticles skin penetration ultradeformable liposomes zebrafish amino functionalized silicon nanoparticle liposome nanoparticle photosensitizing agent reactive oxygen metabolite unclassified drug silicon adult animal cell Article cell viability controlled study cytotoxicity drug delivery system embryo epidermis female human human cell human tissue in vitro study in vivo study incubation time nanoencapsulation nonhuman particle size photodynamic therapy priority journal rat tumor cell line zebra fish animal cell survival chemistry drug effect growth, development and aging metabolism photochemotherapy Animals Cell Survival Drug Delivery Systems Humans Liposomes Nanoparticles Photochemotherapy Photosensitizing Agents Reactive Oxygen Species Silicon Zebrafish
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_17435889_v13_n11_p1349_Lillo
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_17435889_v13_n11_p1349_Lillo
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spelling	todo:paper_17435889_v13_n11_p1349_Lillo2023-10-03T16:31:23Z Toward biomedical application of amino-functionalized silicon nanoparticles Lillo, C.R. Natalia Calienni, M. Gorojod, R.M. Rivas Aiello, M.B. Rodriguez Sartori, D. Prieto, M.J. Alonso, S.D.V. Kotler, M.L. Gonzalez, M.C. Montanari, J. PDT radiotherapy silicon nanoparticles skin penetration ultradeformable liposomes zebrafish amino functionalized silicon nanoparticle liposome nanoparticle photosensitizing agent reactive oxygen metabolite unclassified drug liposome nanoparticle photosensitizing agent silicon adult animal cell Article cell viability controlled study cytotoxicity drug delivery system embryo epidermis female human human cell human tissue in vitro study in vivo study incubation time nanoencapsulation nonhuman particle size photodynamic therapy priority journal radiotherapy rat skin penetration tumor cell line zebra fish animal cell survival chemistry drug delivery system drug effect growth, development and aging metabolism photochemotherapy Animals Cell Survival Drug Delivery Systems Humans Liposomes Nanoparticles Photochemotherapy Photosensitizing Agents Reactive Oxygen Species Silicon Zebrafish Silicon blue-emitting nanoparticles (NPs) are promising effectors for photodynamic therapy and radiotherapy, because of their production of reactive oxygen species (ROS) upon irradiation. Results: Amino-functionalized silicon NPs (NH2SiNP) were intrinsically nontoxic below 100 μg/ml in vitro (on two tumor cell lines) and in vivo (zebrafish larvae and embryos). NH2SiNP showed a moderate effect as a photosensitizer for photodynamic therapy and reduced ROS generation in radiotherapy, which could be indicative of a ROS scavenging effect. Encapsulation of NH2SiNP into ultradeformable liposomes improved their skin penetration after topical application, reaching the viable epidermis where neoplastic events occur. Conclusion: Subsequent derivatizations after amino-functionalization and incorporation to nanodrug delivery systems could expand the spectrum of the biomedical application of these kind of silicon NPs. © 2018 Future Medicine Ltd. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_17435889_v13_n11_p1349_Lillo
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	PDT radiotherapy silicon nanoparticles skin penetration ultradeformable liposomes zebrafish amino functionalized silicon nanoparticle liposome nanoparticle photosensitizing agent reactive oxygen metabolite unclassified drug liposome nanoparticle photosensitizing agent silicon adult animal cell Article cell viability controlled study cytotoxicity drug delivery system embryo epidermis female human human cell human tissue in vitro study in vivo study incubation time nanoencapsulation nonhuman particle size photodynamic therapy priority journal radiotherapy rat skin penetration tumor cell line zebra fish animal cell survival chemistry drug delivery system drug effect growth, development and aging metabolism photochemotherapy Animals Cell Survival Drug Delivery Systems Humans Liposomes Nanoparticles Photochemotherapy Photosensitizing Agents Reactive Oxygen Species Silicon Zebrafish
spellingShingle	PDT radiotherapy silicon nanoparticles skin penetration ultradeformable liposomes zebrafish amino functionalized silicon nanoparticle liposome nanoparticle photosensitizing agent reactive oxygen metabolite unclassified drug liposome nanoparticle photosensitizing agent silicon adult animal cell Article cell viability controlled study cytotoxicity drug delivery system embryo epidermis female human human cell human tissue in vitro study in vivo study incubation time nanoencapsulation nonhuman particle size photodynamic therapy priority journal radiotherapy rat skin penetration tumor cell line zebra fish animal cell survival chemistry drug delivery system drug effect growth, development and aging metabolism photochemotherapy Animals Cell Survival Drug Delivery Systems Humans Liposomes Nanoparticles Photochemotherapy Photosensitizing Agents Reactive Oxygen Species Silicon Zebrafish Lillo, C.R. Natalia Calienni, M. Gorojod, R.M. Rivas Aiello, M.B. Rodriguez Sartori, D. Prieto, M.J. Alonso, S.D.V. Kotler, M.L. Gonzalez, M.C. Montanari, J. Toward biomedical application of amino-functionalized silicon nanoparticles
topic_facet	PDT radiotherapy silicon nanoparticles skin penetration ultradeformable liposomes zebrafish amino functionalized silicon nanoparticle liposome nanoparticle photosensitizing agent reactive oxygen metabolite unclassified drug liposome nanoparticle photosensitizing agent silicon adult animal cell Article cell viability controlled study cytotoxicity drug delivery system embryo epidermis female human human cell human tissue in vitro study in vivo study incubation time nanoencapsulation nonhuman particle size photodynamic therapy priority journal radiotherapy rat skin penetration tumor cell line zebra fish animal cell survival chemistry drug delivery system drug effect growth, development and aging metabolism photochemotherapy Animals Cell Survival Drug Delivery Systems Humans Liposomes Nanoparticles Photochemotherapy Photosensitizing Agents Reactive Oxygen Species Silicon Zebrafish
description	Silicon blue-emitting nanoparticles (NPs) are promising effectors for photodynamic therapy and radiotherapy, because of their production of reactive oxygen species (ROS) upon irradiation. Results: Amino-functionalized silicon NPs (NH2SiNP) were intrinsically nontoxic below 100 μg/ml in vitro (on two tumor cell lines) and in vivo (zebrafish larvae and embryos). NH2SiNP showed a moderate effect as a photosensitizer for photodynamic therapy and reduced ROS generation in radiotherapy, which could be indicative of a ROS scavenging effect. Encapsulation of NH2SiNP into ultradeformable liposomes improved their skin penetration after topical application, reaching the viable epidermis where neoplastic events occur. Conclusion: Subsequent derivatizations after amino-functionalization and incorporation to nanodrug delivery systems could expand the spectrum of the biomedical application of these kind of silicon NPs. © 2018 Future Medicine Ltd.
format	JOUR
author	Lillo, C.R. Natalia Calienni, M. Gorojod, R.M. Rivas Aiello, M.B. Rodriguez Sartori, D. Prieto, M.J. Alonso, S.D.V. Kotler, M.L. Gonzalez, M.C. Montanari, J.
author_facet	Lillo, C.R. Natalia Calienni, M. Gorojod, R.M. Rivas Aiello, M.B. Rodriguez Sartori, D. Prieto, M.J. Alonso, S.D.V. Kotler, M.L. Gonzalez, M.C. Montanari, J.
author_sort	Lillo, C.R.
title	Toward biomedical application of amino-functionalized silicon nanoparticles
title_short	Toward biomedical application of amino-functionalized silicon nanoparticles
title_full	Toward biomedical application of amino-functionalized silicon nanoparticles
title_fullStr	Toward biomedical application of amino-functionalized silicon nanoparticles
title_full_unstemmed	Toward biomedical application of amino-functionalized silicon nanoparticles
title_sort	toward biomedical application of amino-functionalized silicon nanoparticles
url	http://hdl.handle.net/20.500.12110/paper_17435889_v13_n11_p1349_Lillo
work_keys_str_mv	AT lillocr towardbiomedicalapplicationofaminofunctionalizedsiliconnanoparticles AT nataliacaliennim towardbiomedicalapplicationofaminofunctionalizedsiliconnanoparticles AT gorojodrm towardbiomedicalapplicationofaminofunctionalizedsiliconnanoparticles AT rivasaiellomb towardbiomedicalapplicationofaminofunctionalizedsiliconnanoparticles AT rodriguezsartorid towardbiomedicalapplicationofaminofunctionalizedsiliconnanoparticles AT prietomj towardbiomedicalapplicationofaminofunctionalizedsiliconnanoparticles AT alonsosdv towardbiomedicalapplicationofaminofunctionalizedsiliconnanoparticles AT kotlerml towardbiomedicalapplicationofaminofunctionalizedsiliconnanoparticles AT gonzalezmc towardbiomedicalapplicationofaminofunctionalizedsiliconnanoparticles AT montanarij towardbiomedicalapplicationofaminofunctionalizedsiliconnanoparticles
_version_	1807319944742830080

Toward biomedical application of amino-functionalized silicon nanoparticles

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