Regulatory and mechanistic actions of glucocorticoids on T and inflammatory cells

Glucocorticoids (GCs) play an important role in regulating the inflammatory and immune response and have been used since decades to treat various inflammatory and autoimmune disorders. Fine-tuning the glucocorticoid receptor (GR) activity is instrumental in the search for novel therapeutic strategie...

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Autores principales: Liberman, A.C., Budziñski, M.L., Sokn, C., Gobbini, R.P., Steininger, A., Arzt, E.
Formato: JOUR
Materias:
FKBP51
Glucocorticoids
Inflammation
Transactivation
Transrepression
glucocorticoid
glucocorticoid receptor
heat shock protein 90
histone acetyltransferase
interleukin 12
interleukin 6
lipocortin 1
matrix metalloproteinase
phospholipase A2
tumor necrosis factor
alternative RNA splicing
chronic stress
DNA binding
gene expression
immune response
inflammatory cell
nerve cell degeneration
phagocytosis
protein processing
Review
sensitivity and specificity
sumoylation
T lymphocyte
transactivation
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_16642392_v9_nMAY_p_Liberman
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_16642392_v9_nMAY_p_Liberman
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spelling todo:paper_16642392_v9_nMAY_p_Liberman2023-10-03T16:29:05Z Regulatory and mechanistic actions of glucocorticoids on T and inflammatory cells Liberman, A.C. Budziñski, M.L. Sokn, C. Gobbini, R.P. Steininger, A. Arzt, E. FKBP51 Glucocorticoids Inflammation Transactivation Transrepression glucocorticoid glucocorticoid receptor heat shock protein 90 histone acetyltransferase interleukin 12 interleukin 6 lipocortin 1 matrix metalloproteinase phospholipase A2 tumor necrosis factor alternative RNA splicing chronic stress DNA binding gene expression immune response inflammatory cell nerve cell degeneration phagocytosis protein processing Review sensitivity and specificity sumoylation T lymphocyte transactivation Glucocorticoids (GCs) play an important role in regulating the inflammatory and immune response and have been used since decades to treat various inflammatory and autoimmune disorders. Fine-tuning the glucocorticoid receptor (GR) activity is instrumental in the search for novel therapeutic strategies aimed to reduce pathological signaling and restoring homeostasis. Despite the primary anti-inflammatory actions of GCs, there are studies suggesting that under certain conditions GCs may also exert pro-inflammatory responses. For these reasons the understanding of the GR basic mechanisms of action on different immune cells in the periphery (e.g., macrophages, dendritic cells, neutrophils, and T cells) and in the brain (microglia) contexts, that we review in this chapter, is a continuous matter of interest and may reveal novel therapeutic targets for the treatment of immune and inflammatory response. © 2018 Liberman, Budziñski, Sokn, Gobbini, Steininger and Arzt. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_16642392_v9_nMAY_p_Liberman
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic FKBP51
Glucocorticoids
Inflammation
Transactivation
Transrepression
glucocorticoid
glucocorticoid receptor
heat shock protein 90
histone acetyltransferase
interleukin 12
interleukin 6
lipocortin 1
matrix metalloproteinase
phospholipase A2
tumor necrosis factor
alternative RNA splicing
chronic stress
DNA binding
gene expression
immune response
inflammatory cell
nerve cell degeneration
phagocytosis
protein processing
Review
sensitivity and specificity
sumoylation
T lymphocyte
transactivation
spellingShingle FKBP51
Glucocorticoids
Inflammation
Transactivation
Transrepression
glucocorticoid
glucocorticoid receptor
heat shock protein 90
histone acetyltransferase
interleukin 12
interleukin 6
lipocortin 1
matrix metalloproteinase
phospholipase A2
tumor necrosis factor
alternative RNA splicing
chronic stress
DNA binding
gene expression
immune response
inflammatory cell
nerve cell degeneration
phagocytosis
protein processing
Review
sensitivity and specificity
sumoylation
T lymphocyte
transactivation
Liberman, A.C.
Budziñski, M.L.
Sokn, C.
Gobbini, R.P.
Steininger, A.
Arzt, E.
Regulatory and mechanistic actions of glucocorticoids on T and inflammatory cells
topic_facet FKBP51
Glucocorticoids
Inflammation
Transactivation
Transrepression
glucocorticoid
glucocorticoid receptor
heat shock protein 90
histone acetyltransferase
interleukin 12
interleukin 6
lipocortin 1
matrix metalloproteinase
phospholipase A2
tumor necrosis factor
alternative RNA splicing
chronic stress
DNA binding
gene expression
immune response
inflammatory cell
nerve cell degeneration
phagocytosis
protein processing
Review
sensitivity and specificity
sumoylation
T lymphocyte
transactivation
description Glucocorticoids (GCs) play an important role in regulating the inflammatory and immune response and have been used since decades to treat various inflammatory and autoimmune disorders. Fine-tuning the glucocorticoid receptor (GR) activity is instrumental in the search for novel therapeutic strategies aimed to reduce pathological signaling and restoring homeostasis. Despite the primary anti-inflammatory actions of GCs, there are studies suggesting that under certain conditions GCs may also exert pro-inflammatory responses. For these reasons the understanding of the GR basic mechanisms of action on different immune cells in the periphery (e.g., macrophages, dendritic cells, neutrophils, and T cells) and in the brain (microglia) contexts, that we review in this chapter, is a continuous matter of interest and may reveal novel therapeutic targets for the treatment of immune and inflammatory response. © 2018 Liberman, Budziñski, Sokn, Gobbini, Steininger and Arzt.
format JOUR
author Liberman, A.C.
Budziñski, M.L.
Sokn, C.
Gobbini, R.P.
Steininger, A.
Arzt, E.
author_facet Liberman, A.C.
Budziñski, M.L.
Sokn, C.
Gobbini, R.P.
Steininger, A.
Arzt, E.
author_sort Liberman, A.C.
title Regulatory and mechanistic actions of glucocorticoids on T and inflammatory cells
title_short Regulatory and mechanistic actions of glucocorticoids on T and inflammatory cells
title_full Regulatory and mechanistic actions of glucocorticoids on T and inflammatory cells
title_fullStr Regulatory and mechanistic actions of glucocorticoids on T and inflammatory cells
title_full_unstemmed Regulatory and mechanistic actions of glucocorticoids on T and inflammatory cells
title_sort regulatory and mechanistic actions of glucocorticoids on t and inflammatory cells
url http://hdl.handle.net/20.500.12110/paper_16642392_v9_nMAY_p_Liberman
work_keys_str_mv AT libermanac regulatoryandmechanisticactionsofglucocorticoidsontandinflammatorycells
AT budzinskiml regulatoryandmechanisticactionsofglucocorticoidsontandinflammatorycells
AT soknc regulatoryandmechanisticactionsofglucocorticoidsontandinflammatorycells
AT gobbinirp regulatoryandmechanisticactionsofglucocorticoidsontandinflammatorycells
AT steiningera regulatoryandmechanisticactionsofglucocorticoidsontandinflammatorycells
AT arzte regulatoryandmechanisticactionsofglucocorticoidsontandinflammatorycells
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