The actin/spectrin membrane-associated periodic skeleton in neurons

Neurons are the most asymmetric cell types, with their axons commonly extending over lengths that are thousand times longer than the diameter of the cell soma. Fluorescence nanoscopy has recently unveiled that actin, spectrin and accompanying proteins form a membrane-associated periodic skeleton (MP...

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Detalles Bibliográficos
Autores principales:	Unsain, N., Stefani, F.D., Cáceres, A.
Formato:	JOUR
Materias:	actin Axon Cytoskeleton Dendrites Fluorescence nanoscopy Spectrin Super resolution microscopy spectrin axon cell body cell membrane cells by body anatomy dendrite dendritic spine endocytosis exocytosis fluorescence analysis fluorescence nanoscopy human microglia nerve cell oligodendroglia protein domain protein structure Short Survey supramolecular chemistry
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_16633563_v10_nMAY_p_Unsain
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_16633563_v10_nMAY_p_Unsain
record_format	dspace
spelling	todo:paper_16633563_v10_nMAY_p_Unsain2023-10-03T16:28:56Z The actin/spectrin membrane-associated periodic skeleton in neurons Unsain, N. Stefani, F.D. Cáceres, A. actin Axon Cytoskeleton Dendrites Fluorescence nanoscopy Spectrin Super resolution microscopy actin spectrin axon cell body cell membrane cells by body anatomy dendrite dendritic spine endocytosis exocytosis fluorescence analysis fluorescence nanoscopy human microglia nerve cell oligodendroglia protein domain protein structure Short Survey supramolecular chemistry Neurons are the most asymmetric cell types, with their axons commonly extending over lengths that are thousand times longer than the diameter of the cell soma. Fluorescence nanoscopy has recently unveiled that actin, spectrin and accompanying proteins form a membrane-associated periodic skeleton (MPS) that is ubiquitously present in mature axons from all neuronal types evaluated so far. The MPS is a regular supramolecular protein structure consisting of actin "rings" separated by spectrin tetramer "spacers". Although the MPS is best organized in axons, it is also present in dendrites, dendritic spine necks and thin cellular extensions of non-neuronal cells such as oligodendrocytes and microglia. The unique organization of the actin/spectrin skeleton has raised the hypothesis that it might serve to support the extreme physical and structural conditions that axons must resist during the lifespan of an organism. Another plausible function of the MPS consists of membrane compartmentalization and subsequent organization of protein domains. This review focuses on what we know so far about the structure of the MPS in different neuronal subdomains, its dynamics and the emerging evidence of its impact in axonal biology. © 2018 Unsain, Stefani and Cáceres. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_16633563_v10_nMAY_p_Unsain
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	actin Axon Cytoskeleton Dendrites Fluorescence nanoscopy Spectrin Super resolution microscopy actin spectrin axon cell body cell membrane cells by body anatomy dendrite dendritic spine endocytosis exocytosis fluorescence analysis fluorescence nanoscopy human microglia nerve cell oligodendroglia protein domain protein structure Short Survey supramolecular chemistry
spellingShingle	actin Axon Cytoskeleton Dendrites Fluorescence nanoscopy Spectrin Super resolution microscopy actin spectrin axon cell body cell membrane cells by body anatomy dendrite dendritic spine endocytosis exocytosis fluorescence analysis fluorescence nanoscopy human microglia nerve cell oligodendroglia protein domain protein structure Short Survey supramolecular chemistry Unsain, N. Stefani, F.D. Cáceres, A. The actin/spectrin membrane-associated periodic skeleton in neurons
topic_facet	actin Axon Cytoskeleton Dendrites Fluorescence nanoscopy Spectrin Super resolution microscopy actin spectrin axon cell body cell membrane cells by body anatomy dendrite dendritic spine endocytosis exocytosis fluorescence analysis fluorescence nanoscopy human microglia nerve cell oligodendroglia protein domain protein structure Short Survey supramolecular chemistry
description	Neurons are the most asymmetric cell types, with their axons commonly extending over lengths that are thousand times longer than the diameter of the cell soma. Fluorescence nanoscopy has recently unveiled that actin, spectrin and accompanying proteins form a membrane-associated periodic skeleton (MPS) that is ubiquitously present in mature axons from all neuronal types evaluated so far. The MPS is a regular supramolecular protein structure consisting of actin "rings" separated by spectrin tetramer "spacers". Although the MPS is best organized in axons, it is also present in dendrites, dendritic spine necks and thin cellular extensions of non-neuronal cells such as oligodendrocytes and microglia. The unique organization of the actin/spectrin skeleton has raised the hypothesis that it might serve to support the extreme physical and structural conditions that axons must resist during the lifespan of an organism. Another plausible function of the MPS consists of membrane compartmentalization and subsequent organization of protein domains. This review focuses on what we know so far about the structure of the MPS in different neuronal subdomains, its dynamics and the emerging evidence of its impact in axonal biology. © 2018 Unsain, Stefani and Cáceres.
format	JOUR
author	Unsain, N. Stefani, F.D. Cáceres, A.
author_facet	Unsain, N. Stefani, F.D. Cáceres, A.
author_sort	Unsain, N.
title	The actin/spectrin membrane-associated periodic skeleton in neurons
title_short	The actin/spectrin membrane-associated periodic skeleton in neurons
title_full	The actin/spectrin membrane-associated periodic skeleton in neurons
title_fullStr	The actin/spectrin membrane-associated periodic skeleton in neurons
title_full_unstemmed	The actin/spectrin membrane-associated periodic skeleton in neurons
title_sort	actin/spectrin membrane-associated periodic skeleton in neurons
url	http://hdl.handle.net/20.500.12110/paper_16633563_v10_nMAY_p_Unsain
work_keys_str_mv	AT unsainn theactinspectrinmembraneassociatedperiodicskeletoninneurons AT stefanifd theactinspectrinmembraneassociatedperiodicskeletoninneurons AT caceresa theactinspectrinmembraneassociatedperiodicskeletoninneurons AT unsainn actinspectrinmembraneassociatedperiodicskeletoninneurons AT stefanifd actinspectrinmembraneassociatedperiodicskeletoninneurons AT caceresa actinspectrinmembraneassociatedperiodicskeletoninneurons
_version_	1807322305173389312

The actin/spectrin membrane-associated periodic skeleton in neurons

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