Lateral Habenula determines long-term storage of aversive memories

The Lateral Habenula (LHb) is a small brain structure that codifies negative motivational value and has been related to major depression. It has been shown recently that LHb activation is sufficient to induce aversive associative learning; however the key question about whether LHb activation is req...

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Autores principales: Tomaiuolo, M., Gonzalez, C., Medina, J.H., Piriz, J.
Formato: JOUR
Materias:
Fear memory
Inhibitory avoidance learning
Lateral Habenula
Memory persistence
Rats
Wistar
animal experiment
animal tissue
article
controlled study
elevated plus maze test
fear
habenula
lateral habenula
long term memory
male
memory consolidation
nonhuman
open field test
passive avoidance test
rat
state dependent learning
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_16625153_v8_nMAY_p_Tomaiuolo
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_16625153_v8_nMAY_p_Tomaiuolo
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spelling todo:paper_16625153_v8_nMAY_p_Tomaiuolo2023-10-03T16:28:52Z Lateral Habenula determines long-term storage of aversive memories Tomaiuolo, M. Gonzalez, C. Medina, J.H. Piriz, J. Fear memory Inhibitory avoidance learning Lateral Habenula Memory persistence Rats Wistar animal experiment animal tissue article controlled study elevated plus maze test fear habenula lateral habenula long term memory male memory consolidation nonhuman open field test passive avoidance test rat state dependent learning The Lateral Habenula (LHb) is a small brain structure that codifies negative motivational value and has been related to major depression. It has been shown recently that LHb activation is sufficient to induce aversive associative learning; however the key question about whether LHb activation is required for an aversive memory to be formed has not been addressed. In this article we studied the function of the LHb in memory formation using the Inhibitory Avoidance task (IA). We found that LHb inactivation during IA training does not disrupt memory when assessed 24 h after, but abolishes it 7 days later, indicating that LHb activity during memory acquisition is not necessary for memory formation, but regulates its temporal stability. These effects suggest that LHb inactivation modifies subjective perception of the training experience. © 2014 Tomaiuolo, Gonzalez, Medina and Piriz. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_16625153_v8_nMAY_p_Tomaiuolo
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Fear memory
Inhibitory avoidance learning
Lateral Habenula
Memory persistence
Rats
Wistar
animal experiment
animal tissue
article
controlled study
elevated plus maze test
fear
habenula
lateral habenula
long term memory
male
memory consolidation
nonhuman
open field test
passive avoidance test
rat
state dependent learning
spellingShingle Fear memory
Inhibitory avoidance learning
Lateral Habenula
Memory persistence
Rats
Wistar
animal experiment
animal tissue
article
controlled study
elevated plus maze test
fear
habenula
lateral habenula
long term memory
male
memory consolidation
nonhuman
open field test
passive avoidance test
rat
state dependent learning
Tomaiuolo, M.
Gonzalez, C.
Medina, J.H.
Piriz, J.
Lateral Habenula determines long-term storage of aversive memories
topic_facet Fear memory
Inhibitory avoidance learning
Lateral Habenula
Memory persistence
Rats
Wistar
animal experiment
animal tissue
article
controlled study
elevated plus maze test
fear
habenula
lateral habenula
long term memory
male
memory consolidation
nonhuman
open field test
passive avoidance test
rat
state dependent learning
description The Lateral Habenula (LHb) is a small brain structure that codifies negative motivational value and has been related to major depression. It has been shown recently that LHb activation is sufficient to induce aversive associative learning; however the key question about whether LHb activation is required for an aversive memory to be formed has not been addressed. In this article we studied the function of the LHb in memory formation using the Inhibitory Avoidance task (IA). We found that LHb inactivation during IA training does not disrupt memory when assessed 24 h after, but abolishes it 7 days later, indicating that LHb activity during memory acquisition is not necessary for memory formation, but regulates its temporal stability. These effects suggest that LHb inactivation modifies subjective perception of the training experience. © 2014 Tomaiuolo, Gonzalez, Medina and Piriz.
format JOUR
author Tomaiuolo, M.
Gonzalez, C.
Medina, J.H.
Piriz, J.
author_facet Tomaiuolo, M.
Gonzalez, C.
Medina, J.H.
Piriz, J.
author_sort Tomaiuolo, M.
title Lateral Habenula determines long-term storage of aversive memories
title_short Lateral Habenula determines long-term storage of aversive memories
title_full Lateral Habenula determines long-term storage of aversive memories
title_fullStr Lateral Habenula determines long-term storage of aversive memories
title_full_unstemmed Lateral Habenula determines long-term storage of aversive memories
title_sort lateral habenula determines long-term storage of aversive memories
url http://hdl.handle.net/20.500.12110/paper_16625153_v8_nMAY_p_Tomaiuolo
work_keys_str_mv AT tomaiuolom lateralhabenuladetermineslongtermstorageofaversivememories
AT gonzalezc lateralhabenuladetermineslongtermstorageofaversivememories
AT medinajh lateralhabenuladetermineslongtermstorageofaversivememories
AT pirizj lateralhabenuladetermineslongtermstorageofaversivememories
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