CaMKII isoforms in learning and memory: Localization and function

Calcium/calmodulin-dependent protein kinase II (CaMKII) is a key protein kinase in neural plasticity and memory, as have been shown in several studies since the first evidence in long-term potentiation (LTP) 30 years ago. However, most of the studies were focused mainly in one of the four isoforms o...

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Autores principales:	Zalcman, G., Federman, N., Romano, A.
Formato:	JOUR
Materias:	CaMKII CaMKIIα CaMKIIβ CaMKIIγ CaMKIIδ Learning Memory calcium calmodulin dependent protein kinase II calcium calmodulin dependent protein kinase II alpha calcium calmodulin dependent protein kinase II beta calcium calmodulin dependent protein kinase II delta calcium calmodulin dependent protein kinase II gamma isoprotein n methyl dextro aspartic acid receptor unclassified drug autophosphorylation brain injury calcium signaling cell migration gene expression glutamatergic synapse human learning learning disorder long term potentiation memory nerve cell plasticity nerve growth neurite outgrowth neurotransmitter release nonhuman protein expression protein phosphorylation protein processing regulatory mechanism reperfusion injury Review signal transduction spatial memory
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_16625099_v11_n_p_Zalcman
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_16625099_v11_n_p_Zalcman
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spelling	todo:paper_16625099_v11_n_p_Zalcman2023-10-03T16:28:45Z CaMKII isoforms in learning and memory: Localization and function Zalcman, G. Federman, N. Romano, A. CaMKII CaMKIIα CaMKIIβ CaMKIIγ CaMKIIδ Learning Memory calcium calmodulin dependent protein kinase II calcium calmodulin dependent protein kinase II alpha calcium calmodulin dependent protein kinase II beta calcium calmodulin dependent protein kinase II delta calcium calmodulin dependent protein kinase II gamma isoprotein n methyl dextro aspartic acid receptor unclassified drug autophosphorylation brain injury calcium signaling cell migration gene expression glutamatergic synapse human learning learning disorder long term potentiation memory nerve cell plasticity nerve growth neurite outgrowth neurotransmitter release nonhuman protein expression protein phosphorylation protein processing regulatory mechanism reperfusion injury Review signal transduction spatial memory Calcium/calmodulin-dependent protein kinase II (CaMKII) is a key protein kinase in neural plasticity and memory, as have been shown in several studies since the first evidence in long-term potentiation (LTP) 30 years ago. However, most of the studies were focused mainly in one of the four isoforms of this protein kinase, the CaMKIIα. Here we review the characteristics and the role of each of the four isoforms in learning, memory and neural plasticity, considering the well known local role of α and β isoforms in dendritic terminals as well as recent findings about the γ isoform as calcium signals transducers from synapse to nucleus and δ isoform as a kinase required for a more persistent memory trace. © 2018 Zalcman, Federman and Romano. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_16625099_v11_n_p_Zalcman
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	CaMKII CaMKIIα CaMKIIβ CaMKIIγ CaMKIIδ Learning Memory calcium calmodulin dependent protein kinase II calcium calmodulin dependent protein kinase II alpha calcium calmodulin dependent protein kinase II beta calcium calmodulin dependent protein kinase II delta calcium calmodulin dependent protein kinase II gamma isoprotein n methyl dextro aspartic acid receptor unclassified drug autophosphorylation brain injury calcium signaling cell migration gene expression glutamatergic synapse human learning learning disorder long term potentiation memory nerve cell plasticity nerve growth neurite outgrowth neurotransmitter release nonhuman protein expression protein phosphorylation protein processing regulatory mechanism reperfusion injury Review signal transduction spatial memory
spellingShingle	CaMKII CaMKIIα CaMKIIβ CaMKIIγ CaMKIIδ Learning Memory calcium calmodulin dependent protein kinase II calcium calmodulin dependent protein kinase II alpha calcium calmodulin dependent protein kinase II beta calcium calmodulin dependent protein kinase II delta calcium calmodulin dependent protein kinase II gamma isoprotein n methyl dextro aspartic acid receptor unclassified drug autophosphorylation brain injury calcium signaling cell migration gene expression glutamatergic synapse human learning learning disorder long term potentiation memory nerve cell plasticity nerve growth neurite outgrowth neurotransmitter release nonhuman protein expression protein phosphorylation protein processing regulatory mechanism reperfusion injury Review signal transduction spatial memory Zalcman, G. Federman, N. Romano, A. CaMKII isoforms in learning and memory: Localization and function
topic_facet	CaMKII CaMKIIα CaMKIIβ CaMKIIγ CaMKIIδ Learning Memory calcium calmodulin dependent protein kinase II calcium calmodulin dependent protein kinase II alpha calcium calmodulin dependent protein kinase II beta calcium calmodulin dependent protein kinase II delta calcium calmodulin dependent protein kinase II gamma isoprotein n methyl dextro aspartic acid receptor unclassified drug autophosphorylation brain injury calcium signaling cell migration gene expression glutamatergic synapse human learning learning disorder long term potentiation memory nerve cell plasticity nerve growth neurite outgrowth neurotransmitter release nonhuman protein expression protein phosphorylation protein processing regulatory mechanism reperfusion injury Review signal transduction spatial memory
description	Calcium/calmodulin-dependent protein kinase II (CaMKII) is a key protein kinase in neural plasticity and memory, as have been shown in several studies since the first evidence in long-term potentiation (LTP) 30 years ago. However, most of the studies were focused mainly in one of the four isoforms of this protein kinase, the CaMKIIα. Here we review the characteristics and the role of each of the four isoforms in learning, memory and neural plasticity, considering the well known local role of α and β isoforms in dendritic terminals as well as recent findings about the γ isoform as calcium signals transducers from synapse to nucleus and δ isoform as a kinase required for a more persistent memory trace. © 2018 Zalcman, Federman and Romano.
format	JOUR
author	Zalcman, G. Federman, N. Romano, A.
author_facet	Zalcman, G. Federman, N. Romano, A.
author_sort	Zalcman, G.
title	CaMKII isoforms in learning and memory: Localization and function
title_short	CaMKII isoforms in learning and memory: Localization and function
title_full	CaMKII isoforms in learning and memory: Localization and function
title_fullStr	CaMKII isoforms in learning and memory: Localization and function
title_full_unstemmed	CaMKII isoforms in learning and memory: Localization and function
title_sort	camkii isoforms in learning and memory: localization and function
url	http://hdl.handle.net/20.500.12110/paper_16625099_v11_n_p_Zalcman
work_keys_str_mv	AT zalcmang camkiiisoformsinlearningandmemorylocalizationandfunction AT federmann camkiiisoformsinlearningandmemorylocalizationandfunction AT romanoa camkiiisoformsinlearningandmemorylocalizationandfunction
_version_	1807320150281551872

CaMKII isoforms in learning and memory: Localization and function

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