Polyoxygenated steroids from the octocoral leptogorgia punicea and in vitro evaluation of their cytotoxic activity

Five new polyoxygenated marine steroids-punicinols A-E (1-5)-were isolated from the gorgonian Leptogorgia punicea and characterized by spectroscopic methods (IR, MS, 1H, 13C and 2-D NMR). The five compounds induced in vitro cytotoxic effects against lung cancer A549 cells, while punicinols A and B w...

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Detalles Bibliográficos
Autores principales: Moritz, M.I.G., Marostica, L.L., Bianco, É.M., Almeida, M.T.R., Carraro, J.L., Cabrera, G.M., Palermo, J.A., Simões, C.M.O., Schenkel, E.P.
Formato: JOUR
Materias:
A549 cells
Cytotoxic effects
Leptogorgia punicea
Lung cancer cells
Octocoral
Polyoxygenated steroids
cytotoxic agent
paclitaxel
punicinol A
punicinol B
punicinol C
punicinol D
punicinol E
unclassified drug
steroid
A549 cell line
antiproliferative activity
Article
biological activity
carbon nuclear magnetic resonance
clonogenic assay
controlled study
coral
drug cytotoxicity
drug effect
drug isolation
drug potentiation
drug structure
IC50
in vitro study
infrared spectroscopy
mass spectrometry
nonhuman
physical chemistry
proton nuclear magnetic resonance
animal
Anthozoa
cell cycle
chemistry
drug effects
human
Lung Neoplasms
nuclear magnetic resonance spectroscopy
procedures
tumor cell line
Gorgonia
Animals
Cell Cycle
Cell Line, Tumor
Drug Synergism
Humans
Magnetic Resonance Spectroscopy
Paclitaxel
Steroids
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_16603397_v12_n12_p5864_Moritz
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Five new polyoxygenated marine steroids-punicinols A-E (1-5)-were isolated from the gorgonian Leptogorgia punicea and characterized by spectroscopic methods (IR, MS, 1H, 13C and 2-D NMR). The five compounds induced in vitro cytotoxic effects against lung cancer A549 cells, while punicinols A and B were the most active, with IC50 values of 9.7 μM and 9.6 μM, respectively. The synergistic effects of these compounds with paclitaxel, as well as their effects on cell cycle distribution and their performance in the clonogenic assay, were also evaluated. Both compounds demonstrated significant synergistic effects with paclitaxel. © 2014 by the authors licensee MDPI Basel Switzerland.

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