Polyoxygenated steroids from the octocoral leptogorgia punicea and in vitro evaluation of their cytotoxic activity

Five new polyoxygenated marine steroids-punicinols A-E (1-5)-were isolated from the gorgonian Leptogorgia punicea and characterized by spectroscopic methods (IR, MS, 1H, 13C and 2-D NMR). The five compounds induced in vitro cytotoxic effects against lung cancer A549 cells, while punicinols A and B w...

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Autores principales:	Moritz, M.I.G., Marostica, L.L., Bianco, É.M., Almeida, M.T.R., Carraro, J.L., Cabrera, G.M., Palermo, J.A., Simões, C.M.O., Schenkel, E.P.
Formato:	JOUR
Materias:	A549 cells Cytotoxic effects Leptogorgia punicea Lung cancer cells Octocoral Polyoxygenated steroids cytotoxic agent paclitaxel punicinol A punicinol B punicinol C punicinol D punicinol E unclassified drug steroid A549 cell line antiproliferative activity Article biological activity carbon nuclear magnetic resonance clonogenic assay controlled study coral drug cytotoxicity drug effect drug isolation drug potentiation drug structure IC50 in vitro study infrared spectroscopy mass spectrometry nonhuman physical chemistry proton nuclear magnetic resonance animal Anthozoa cell cycle chemistry drug effects human Lung Neoplasms nuclear magnetic resonance spectroscopy procedures tumor cell line Gorgonia Animals Cell Cycle Cell Line, Tumor Drug Synergism Humans Magnetic Resonance Spectroscopy Paclitaxel Steroids
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_16603397_v12_n12_p5864_Moritz
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_16603397_v12_n12_p5864_Moritz
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spelling	todo:paper_16603397_v12_n12_p5864_Moritz2023-10-03T16:28:39Z Polyoxygenated steroids from the octocoral leptogorgia punicea and in vitro evaluation of their cytotoxic activity Moritz, M.I.G. Marostica, L.L. Bianco, É.M. Almeida, M.T.R. Carraro, J.L. Cabrera, G.M. Palermo, J.A. Simões, C.M.O. Schenkel, E.P. A549 cells Cytotoxic effects Leptogorgia punicea Lung cancer cells Octocoral Polyoxygenated steroids cytotoxic agent paclitaxel punicinol A punicinol B punicinol C punicinol D punicinol E unclassified drug paclitaxel steroid A549 cell line antiproliferative activity Article biological activity carbon nuclear magnetic resonance clonogenic assay controlled study coral drug cytotoxicity drug effect drug isolation drug potentiation drug structure IC50 in vitro study infrared spectroscopy Leptogorgia punicea mass spectrometry nonhuman physical chemistry proton nuclear magnetic resonance animal Anthozoa cell cycle chemistry drug effects human Lung Neoplasms nuclear magnetic resonance spectroscopy procedures tumor cell line Gorgonia Leptogorgia punicea Animals Anthozoa Cell Cycle Cell Line, Tumor Drug Synergism Humans Lung Neoplasms Magnetic Resonance Spectroscopy Paclitaxel Steroids Five new polyoxygenated marine steroids-punicinols A-E (1-5)-were isolated from the gorgonian Leptogorgia punicea and characterized by spectroscopic methods (IR, MS, 1H, 13C and 2-D NMR). The five compounds induced in vitro cytotoxic effects against lung cancer A549 cells, while punicinols A and B were the most active, with IC50 values of 9.7 μM and 9.6 μM, respectively. The synergistic effects of these compounds with paclitaxel, as well as their effects on cell cycle distribution and their performance in the clonogenic assay, were also evaluated. Both compounds demonstrated significant synergistic effects with paclitaxel. © 2014 by the authors licensee MDPI Basel Switzerland. Fil:Cabrera, G.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Palermo, J.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_16603397_v12_n12_p5864_Moritz
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	A549 cells Cytotoxic effects Leptogorgia punicea Lung cancer cells Octocoral Polyoxygenated steroids cytotoxic agent paclitaxel punicinol A punicinol B punicinol C punicinol D punicinol E unclassified drug paclitaxel steroid A549 cell line antiproliferative activity Article biological activity carbon nuclear magnetic resonance clonogenic assay controlled study coral drug cytotoxicity drug effect drug isolation drug potentiation drug structure IC50 in vitro study infrared spectroscopy Leptogorgia punicea mass spectrometry nonhuman physical chemistry proton nuclear magnetic resonance animal Anthozoa cell cycle chemistry drug effects human Lung Neoplasms nuclear magnetic resonance spectroscopy procedures tumor cell line Gorgonia Leptogorgia punicea Animals Anthozoa Cell Cycle Cell Line, Tumor Drug Synergism Humans Lung Neoplasms Magnetic Resonance Spectroscopy Paclitaxel Steroids
spellingShingle	A549 cells Cytotoxic effects Leptogorgia punicea Lung cancer cells Octocoral Polyoxygenated steroids cytotoxic agent paclitaxel punicinol A punicinol B punicinol C punicinol D punicinol E unclassified drug paclitaxel steroid A549 cell line antiproliferative activity Article biological activity carbon nuclear magnetic resonance clonogenic assay controlled study coral drug cytotoxicity drug effect drug isolation drug potentiation drug structure IC50 in vitro study infrared spectroscopy Leptogorgia punicea mass spectrometry nonhuman physical chemistry proton nuclear magnetic resonance animal Anthozoa cell cycle chemistry drug effects human Lung Neoplasms nuclear magnetic resonance spectroscopy procedures tumor cell line Gorgonia Leptogorgia punicea Animals Anthozoa Cell Cycle Cell Line, Tumor Drug Synergism Humans Lung Neoplasms Magnetic Resonance Spectroscopy Paclitaxel Steroids Moritz, M.I.G. Marostica, L.L. Bianco, É.M. Almeida, M.T.R. Carraro, J.L. Cabrera, G.M. Palermo, J.A. Simões, C.M.O. Schenkel, E.P. Polyoxygenated steroids from the octocoral leptogorgia punicea and in vitro evaluation of their cytotoxic activity
topic_facet	A549 cells Cytotoxic effects Leptogorgia punicea Lung cancer cells Octocoral Polyoxygenated steroids cytotoxic agent paclitaxel punicinol A punicinol B punicinol C punicinol D punicinol E unclassified drug paclitaxel steroid A549 cell line antiproliferative activity Article biological activity carbon nuclear magnetic resonance clonogenic assay controlled study coral drug cytotoxicity drug effect drug isolation drug potentiation drug structure IC50 in vitro study infrared spectroscopy Leptogorgia punicea mass spectrometry nonhuman physical chemistry proton nuclear magnetic resonance animal Anthozoa cell cycle chemistry drug effects human Lung Neoplasms nuclear magnetic resonance spectroscopy procedures tumor cell line Gorgonia Leptogorgia punicea Animals Anthozoa Cell Cycle Cell Line, Tumor Drug Synergism Humans Lung Neoplasms Magnetic Resonance Spectroscopy Paclitaxel Steroids
description	Five new polyoxygenated marine steroids-punicinols A-E (1-5)-were isolated from the gorgonian Leptogorgia punicea and characterized by spectroscopic methods (IR, MS, 1H, 13C and 2-D NMR). The five compounds induced in vitro cytotoxic effects against lung cancer A549 cells, while punicinols A and B were the most active, with IC50 values of 9.7 μM and 9.6 μM, respectively. The synergistic effects of these compounds with paclitaxel, as well as their effects on cell cycle distribution and their performance in the clonogenic assay, were also evaluated. Both compounds demonstrated significant synergistic effects with paclitaxel. © 2014 by the authors licensee MDPI Basel Switzerland.
format	JOUR
author	Moritz, M.I.G. Marostica, L.L. Bianco, É.M. Almeida, M.T.R. Carraro, J.L. Cabrera, G.M. Palermo, J.A. Simões, C.M.O. Schenkel, E.P.
author_facet	Moritz, M.I.G. Marostica, L.L. Bianco, É.M. Almeida, M.T.R. Carraro, J.L. Cabrera, G.M. Palermo, J.A. Simões, C.M.O. Schenkel, E.P.
author_sort	Moritz, M.I.G.
title	Polyoxygenated steroids from the octocoral leptogorgia punicea and in vitro evaluation of their cytotoxic activity
title_short	Polyoxygenated steroids from the octocoral leptogorgia punicea and in vitro evaluation of their cytotoxic activity
title_full	Polyoxygenated steroids from the octocoral leptogorgia punicea and in vitro evaluation of their cytotoxic activity
title_fullStr	Polyoxygenated steroids from the octocoral leptogorgia punicea and in vitro evaluation of their cytotoxic activity
title_full_unstemmed	Polyoxygenated steroids from the octocoral leptogorgia punicea and in vitro evaluation of their cytotoxic activity
title_sort	polyoxygenated steroids from the octocoral leptogorgia punicea and in vitro evaluation of their cytotoxic activity
url	http://hdl.handle.net/20.500.12110/paper_16603397_v12_n12_p5864_Moritz
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Polyoxygenated steroids from the octocoral leptogorgia punicea and in vitro evaluation of their cytotoxic activity

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