Cytotoxic activity of semi-synthetic derivatives of elatol and isoobtusol

In the present study, the in vitro cytotoxic effects of six semi-synthetic derivatives of elatol (1) and isoobtusol (2) were investigated. Chemical modifications were performed on the hydroxyl groups aiming to get derivatives of different polarity, namely the hemisuccinate, carbamate and sulfamate....

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Detalles Bibliográficos
Autores principales: Lang, K.L., Silva, I.T., Zimmermann, L.A., Lhullier, C., Arana, M.V.M., Palermo, J.A., Falkenberg, M., Simões, C.M.O., Schenkel, E.P., Durán, F.J.
Formato: JOUR
Materias:
Cytotoxic activity
Elatol
Isoobtusol
Sesquiterpenes
Synthesis
cytotoxic agent
elatol 9 carbamate
elatol 9 hemisuccinate
elatol 9 sulfamate
elatol derivative
hydroxyl group
isoobtusol 9 carbamate
isoobtusol 9 hemisuccinate
isoobtusol 9 sulfamate
isoobtusol derivative
unclassified drug
article
cancer cell culture
chemical modification
concentration response
controlled study
drug cytotoxicity
drug structure
embryo
human
human cell
in vitro study
mass spectrometry
nuclear magnetic resonance
rhabdomyosarcoma
Antineoplastic Agents
Cell Line
Humans
Laurencia
Molecular Structure
Spiro Compounds
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_16603397_v10_n10_p2254_Lang
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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