Cytotoxic activity of semi-synthetic derivatives of elatol and isoobtusol
In the present study, the in vitro cytotoxic effects of six semi-synthetic derivatives of elatol (1) and isoobtusol (2) were investigated. Chemical modifications were performed on the hydroxyl groups aiming to get derivatives of different polarity, namely the hemisuccinate, carbamate and sulfamate....
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todo:paper_16603397_v10_n10_p2254_Lang2023-10-03T16:28:38Z Cytotoxic activity of semi-synthetic derivatives of elatol and isoobtusol Lang, K.L. Silva, I.T. Zimmermann, L.A. Lhullier, C. Arana, M.V.M. Palermo, J.A. Falkenberg, M. Simões, C.M.O. Schenkel, E.P. Durán, F.J. Cytotoxic activity Elatol Isoobtusol Sesquiterpenes Synthesis cytotoxic agent elatol 9 carbamate elatol 9 hemisuccinate elatol 9 sulfamate elatol derivative hydroxyl group isoobtusol 9 carbamate isoobtusol 9 hemisuccinate isoobtusol 9 sulfamate isoobtusol derivative unclassified drug article cancer cell culture chemical modification concentration response controlled study drug cytotoxicity drug structure embryo human human cell in vitro study mass spectrometry nuclear magnetic resonance rhabdomyosarcoma Antineoplastic Agents Cell Line Humans Laurencia Molecular Structure Spiro Compounds In the present study, the in vitro cytotoxic effects of six semi-synthetic derivatives of elatol (1) and isoobtusol (2) were investigated. Chemical modifications were performed on the hydroxyl groups aiming to get derivatives of different polarity, namely the hemisuccinate, carbamate and sulfamate. The structural elucidation of the new derivatives was based on detailed NMR and MS spectroscopic analyses. The in vitro cytotoxicity of compounds 1 to 8 was evaluated against A459 and RD tumor cell lines with CC50 values ranging from 4.93 to 41.53 μM. These results suggest that the structural modifications performed on both compounds could be considered a good strategy to obtain more active derivatives. © 2012 by the authors; licensee MDPI, Basel, Switzerland. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_16603397_v10_n10_p2254_Lang |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Cytotoxic activity Elatol Isoobtusol Sesquiterpenes Synthesis cytotoxic agent elatol 9 carbamate elatol 9 hemisuccinate elatol 9 sulfamate elatol derivative hydroxyl group isoobtusol 9 carbamate isoobtusol 9 hemisuccinate isoobtusol 9 sulfamate isoobtusol derivative unclassified drug article cancer cell culture chemical modification concentration response controlled study drug cytotoxicity drug structure embryo human human cell in vitro study mass spectrometry nuclear magnetic resonance rhabdomyosarcoma Antineoplastic Agents Cell Line Humans Laurencia Molecular Structure Spiro Compounds |
| spellingShingle |
Cytotoxic activity Elatol Isoobtusol Sesquiterpenes Synthesis cytotoxic agent elatol 9 carbamate elatol 9 hemisuccinate elatol 9 sulfamate elatol derivative hydroxyl group isoobtusol 9 carbamate isoobtusol 9 hemisuccinate isoobtusol 9 sulfamate isoobtusol derivative unclassified drug article cancer cell culture chemical modification concentration response controlled study drug cytotoxicity drug structure embryo human human cell in vitro study mass spectrometry nuclear magnetic resonance rhabdomyosarcoma Antineoplastic Agents Cell Line Humans Laurencia Molecular Structure Spiro Compounds Lang, K.L. Silva, I.T. Zimmermann, L.A. Lhullier, C. Arana, M.V.M. Palermo, J.A. Falkenberg, M. Simões, C.M.O. Schenkel, E.P. Durán, F.J. Cytotoxic activity of semi-synthetic derivatives of elatol and isoobtusol |
| topic_facet |
Cytotoxic activity Elatol Isoobtusol Sesquiterpenes Synthesis cytotoxic agent elatol 9 carbamate elatol 9 hemisuccinate elatol 9 sulfamate elatol derivative hydroxyl group isoobtusol 9 carbamate isoobtusol 9 hemisuccinate isoobtusol 9 sulfamate isoobtusol derivative unclassified drug article cancer cell culture chemical modification concentration response controlled study drug cytotoxicity drug structure embryo human human cell in vitro study mass spectrometry nuclear magnetic resonance rhabdomyosarcoma Antineoplastic Agents Cell Line Humans Laurencia Molecular Structure Spiro Compounds |
| description |
In the present study, the in vitro cytotoxic effects of six semi-synthetic derivatives of elatol (1) and isoobtusol (2) were investigated. Chemical modifications were performed on the hydroxyl groups aiming to get derivatives of different polarity, namely the hemisuccinate, carbamate and sulfamate. The structural elucidation of the new derivatives was based on detailed NMR and MS spectroscopic analyses. The in vitro cytotoxicity of compounds 1 to 8 was evaluated against A459 and RD tumor cell lines with CC50 values ranging from 4.93 to 41.53 μM. These results suggest that the structural modifications performed on both compounds could be considered a good strategy to obtain more active derivatives. © 2012 by the authors; licensee MDPI, Basel, Switzerland. |
| format |
JOUR |
| author |
Lang, K.L. Silva, I.T. Zimmermann, L.A. Lhullier, C. Arana, M.V.M. Palermo, J.A. Falkenberg, M. Simões, C.M.O. Schenkel, E.P. Durán, F.J. |
| author_facet |
Lang, K.L. Silva, I.T. Zimmermann, L.A. Lhullier, C. Arana, M.V.M. Palermo, J.A. Falkenberg, M. Simões, C.M.O. Schenkel, E.P. Durán, F.J. |
| author_sort |
Lang, K.L. |
| title |
Cytotoxic activity of semi-synthetic derivatives of elatol and isoobtusol |
| title_short |
Cytotoxic activity of semi-synthetic derivatives of elatol and isoobtusol |
| title_full |
Cytotoxic activity of semi-synthetic derivatives of elatol and isoobtusol |
| title_fullStr |
Cytotoxic activity of semi-synthetic derivatives of elatol and isoobtusol |
| title_full_unstemmed |
Cytotoxic activity of semi-synthetic derivatives of elatol and isoobtusol |
| title_sort |
cytotoxic activity of semi-synthetic derivatives of elatol and isoobtusol |
| url |
http://hdl.handle.net/20.500.12110/paper_16603397_v10_n10_p2254_Lang |
| work_keys_str_mv |
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| _version_ |
1807314737713643520 |