Intrauterine programming of lipid metabolic alterations in the heart of the offspring of diabetic rats is prevented by maternal diets enriched in olive oil
Scope: Maternal diabetes can program metabolic and cardiovascular diseases in the offspring. The aim of this work was to address whether an olive oil supplemented diet during pregnancy can prevent lipid metabolic alterations in the heart of the offspring of mild diabetic rats. Methods and results: C...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_16134125_v59_n10_p1997_Capobianco |
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todo:paper_16134125_v59_n10_p1997_Capobianco2023-10-03T16:28:09Z Intrauterine programming of lipid metabolic alterations in the heart of the offspring of diabetic rats is prevented by maternal diets enriched in olive oil Capobianco, E. Pelesson, M. Careaga, V. Fornes, D. Canosa, I. Higa, R. Maier, M. Jawerbaum, A. Diabetes in pregnancy Intrauterine programming Lipid metabolism Offspring's heart Olive oil supplementation fatty acid linoleoyl coenzyme A desaturase nitric oxide olive oil peroxisome proliferator activated receptor alpha animal body weight cardiac muscle diet therapy dietary supplement drug effects experimental diabetes mellitus female heart lipid metabolism lipid peroxidation male metabolism pregnancy pregnancy diabetes mellitus Wistar rat Animals Body Weight Diabetes Mellitus, Experimental Dietary Supplements Fatty Acids Female Heart Linoleoyl-CoA Desaturase Lipid Metabolism Lipid Peroxidation Male Myocardium Nitric Oxide Olive Oil PPAR alpha Pregnancy Pregnancy in Diabetics Rats, Wistar Scope: Maternal diabetes can program metabolic and cardiovascular diseases in the offspring. The aim of this work was to address whether an olive oil supplemented diet during pregnancy can prevent lipid metabolic alterations in the heart of the offspring of mild diabetic rats. Methods and results: Control and diabetic Wistar rats were fed during pregnancy with either a standard diet or a 6% olive oil supplemented diet. The heart of adult offspring from diabetic rats showed increases in lipid concentrations (triglycerides in males and phospholipids, cholesterol, and free fatty acids in females), which were prevented with the maternal diets enriched in olive oil. Maternal olive oil supplementation increased the content of unsaturated fatty acids in the hearts of both female and male offspring from diabetic rats (possibly due to a reduction in lipoperoxidation), increased the expression of Δ6 desaturase in the heart of male offspring from diabetic rats, and increased the expression of peroxisome proliferator activated receptor α in the hearts of both female and male offspring from diabetic rats. Conclusion: Relevant alterations in cardiac lipid metabolism were evident in the adult offspring of a mild diabetic rat model, and regulated by maternal diets enriched in olive oil. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_16134125_v59_n10_p1997_Capobianco |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Diabetes in pregnancy Intrauterine programming Lipid metabolism Offspring's heart Olive oil supplementation fatty acid linoleoyl coenzyme A desaturase nitric oxide olive oil peroxisome proliferator activated receptor alpha animal body weight cardiac muscle diet therapy dietary supplement drug effects experimental diabetes mellitus female heart lipid metabolism lipid peroxidation male metabolism pregnancy pregnancy diabetes mellitus Wistar rat Animals Body Weight Diabetes Mellitus, Experimental Dietary Supplements Fatty Acids Female Heart Linoleoyl-CoA Desaturase Lipid Metabolism Lipid Peroxidation Male Myocardium Nitric Oxide Olive Oil PPAR alpha Pregnancy Pregnancy in Diabetics Rats, Wistar |
| spellingShingle |
Diabetes in pregnancy Intrauterine programming Lipid metabolism Offspring's heart Olive oil supplementation fatty acid linoleoyl coenzyme A desaturase nitric oxide olive oil peroxisome proliferator activated receptor alpha animal body weight cardiac muscle diet therapy dietary supplement drug effects experimental diabetes mellitus female heart lipid metabolism lipid peroxidation male metabolism pregnancy pregnancy diabetes mellitus Wistar rat Animals Body Weight Diabetes Mellitus, Experimental Dietary Supplements Fatty Acids Female Heart Linoleoyl-CoA Desaturase Lipid Metabolism Lipid Peroxidation Male Myocardium Nitric Oxide Olive Oil PPAR alpha Pregnancy Pregnancy in Diabetics Rats, Wistar Capobianco, E. Pelesson, M. Careaga, V. Fornes, D. Canosa, I. Higa, R. Maier, M. Jawerbaum, A. Intrauterine programming of lipid metabolic alterations in the heart of the offspring of diabetic rats is prevented by maternal diets enriched in olive oil |
| topic_facet |
Diabetes in pregnancy Intrauterine programming Lipid metabolism Offspring's heart Olive oil supplementation fatty acid linoleoyl coenzyme A desaturase nitric oxide olive oil peroxisome proliferator activated receptor alpha animal body weight cardiac muscle diet therapy dietary supplement drug effects experimental diabetes mellitus female heart lipid metabolism lipid peroxidation male metabolism pregnancy pregnancy diabetes mellitus Wistar rat Animals Body Weight Diabetes Mellitus, Experimental Dietary Supplements Fatty Acids Female Heart Linoleoyl-CoA Desaturase Lipid Metabolism Lipid Peroxidation Male Myocardium Nitric Oxide Olive Oil PPAR alpha Pregnancy Pregnancy in Diabetics Rats, Wistar |
| description |
Scope: Maternal diabetes can program metabolic and cardiovascular diseases in the offspring. The aim of this work was to address whether an olive oil supplemented diet during pregnancy can prevent lipid metabolic alterations in the heart of the offspring of mild diabetic rats. Methods and results: Control and diabetic Wistar rats were fed during pregnancy with either a standard diet or a 6% olive oil supplemented diet. The heart of adult offspring from diabetic rats showed increases in lipid concentrations (triglycerides in males and phospholipids, cholesterol, and free fatty acids in females), which were prevented with the maternal diets enriched in olive oil. Maternal olive oil supplementation increased the content of unsaturated fatty acids in the hearts of both female and male offspring from diabetic rats (possibly due to a reduction in lipoperoxidation), increased the expression of Δ6 desaturase in the heart of male offspring from diabetic rats, and increased the expression of peroxisome proliferator activated receptor α in the hearts of both female and male offspring from diabetic rats. Conclusion: Relevant alterations in cardiac lipid metabolism were evident in the adult offspring of a mild diabetic rat model, and regulated by maternal diets enriched in olive oil. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
| format |
JOUR |
| author |
Capobianco, E. Pelesson, M. Careaga, V. Fornes, D. Canosa, I. Higa, R. Maier, M. Jawerbaum, A. |
| author_facet |
Capobianco, E. Pelesson, M. Careaga, V. Fornes, D. Canosa, I. Higa, R. Maier, M. Jawerbaum, A. |
| author_sort |
Capobianco, E. |
| title |
Intrauterine programming of lipid metabolic alterations in the heart of the offspring of diabetic rats is prevented by maternal diets enriched in olive oil |
| title_short |
Intrauterine programming of lipid metabolic alterations in the heart of the offspring of diabetic rats is prevented by maternal diets enriched in olive oil |
| title_full |
Intrauterine programming of lipid metabolic alterations in the heart of the offspring of diabetic rats is prevented by maternal diets enriched in olive oil |
| title_fullStr |
Intrauterine programming of lipid metabolic alterations in the heart of the offspring of diabetic rats is prevented by maternal diets enriched in olive oil |
| title_full_unstemmed |
Intrauterine programming of lipid metabolic alterations in the heart of the offspring of diabetic rats is prevented by maternal diets enriched in olive oil |
| title_sort |
intrauterine programming of lipid metabolic alterations in the heart of the offspring of diabetic rats is prevented by maternal diets enriched in olive oil |
| url |
http://hdl.handle.net/20.500.12110/paper_16134125_v59_n10_p1997_Capobianco |
| work_keys_str_mv |
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