Phytochemical Study of the Genus Salpichroa (Solanaceae), Chemotaxonomic Considerations, and Biological Evaluation in Prostate and Breast Cancer Cells
Twelve Salpichroa taxa have been phytochemically analyzed. From the aerial parts of S. scandens, four known salpichrolides A, C, I, S, and an unreported withanolide named salpichrolide V (1), were isolated. In S. dependens, S. gayi, S. glandulosa subsp. glandulosa, S. glandulosa subps. weddellii, S....
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todo:paper_16121872_v14_n8_p_Basso2023-10-03T16:27:59Z Phytochemical Study of the Genus Salpichroa (Solanaceae), Chemotaxonomic Considerations, and Biological Evaluation in Prostate and Breast Cancer Cells Basso, A.V. Leiva González, S. Barboza, G.E. Careaga, V.P. Calvo, J.C. Sacca, P.A. Nicotra, V.E. Chemotaxonomic markers Cytotoxic activities Salpichroa Structure elucidation Withanolides 2,3 dihydrosalpicrolide b antineoplastic agent doxorubicin plant medicinal product salpichrolide a salpichrolide c salpichrolide d salpichrolide g salpichrolide m salpichrolide s salpichrolide t salpichrolide v unclassified drug plant medicinal product antineoplastic activity Article breast cancer cancer cell cancer chemotherapy cell density chemotaxonomy column chromatography comparative study controlled study cytotoxicity drug isolation heteronuclear multiple bond correlation heteronuclear single quantum coherence human human cell in vitro study nuclear Overhauser effect prostate carcinoma proton nuclear magnetic resonance Salpichroa Salpichroa dependens Salpichroa gayi Salpichroa glandulosa Salpichroa leucantha Salpichroa micrantha Salpichroa microloba Salpichroa proboscidea Salpichroa ramosissima Salpichroa scandens Salpichroa tristis Salpichroa weberbauerii Solanaceae thin layer chromatography ultraviolet spectrophotometry breast tumor cell survival chemistry drug effects drug screening female isolation and purification male MCF-7 cell line metabolism pathology prostate tumor Solanaceae tumor cell line Breast Neoplasms Cell Line, Tumor Cell Survival Chromatography, Thin Layer Drug Screening Assays, Antitumor Female Humans Male MCF-7 Cells Phytochemicals Prostatic Neoplasms Solanaceae Twelve Salpichroa taxa have been phytochemically analyzed. From the aerial parts of S. scandens, four known salpichrolides A, C, I, S, and an unreported withanolide named salpichrolide V (1), were isolated. In S. dependens, S. gayi, S. glandulosa subsp. glandulosa, S. glandulosa subps. weddellii, S. leucantha, S. micrantha, S. microloba, S. proboscidea, S. ramosissima, S. tristis var. tristis, and S. weberbauerii, no withanolides were found. The chemical content of ca. 85% of the Salpichroa taxa is in agreement with molecular studies, which suggest that Salpichroa and Jaborosa, a genus considered morphologically close to Salpichroa, are distant in the systematic of the Solanoideae subfamily. Moreover, the in vitro cytotoxic activity of a set of natural salpichrolides and derivatives was examined against two prostate carcinoma cell lines (PC3 and LNCaP) and two human breast cancer cell lines (MCF-7 and T47D). Several compounds showed moderate activity (IC50 = 64.91 – 29.97 μm). © 2017 Wiley-VHCA AG, Zurich, Switzerland JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_16121872_v14_n8_p_Basso |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Chemotaxonomic markers Cytotoxic activities Salpichroa Structure elucidation Withanolides 2,3 dihydrosalpicrolide b antineoplastic agent doxorubicin plant medicinal product salpichrolide a salpichrolide c salpichrolide d salpichrolide g salpichrolide m salpichrolide s salpichrolide t salpichrolide v unclassified drug plant medicinal product antineoplastic activity Article breast cancer cancer cell cancer chemotherapy cell density chemotaxonomy column chromatography comparative study controlled study cytotoxicity drug isolation heteronuclear multiple bond correlation heteronuclear single quantum coherence human human cell in vitro study nuclear Overhauser effect prostate carcinoma proton nuclear magnetic resonance Salpichroa Salpichroa dependens Salpichroa gayi Salpichroa glandulosa Salpichroa leucantha Salpichroa micrantha Salpichroa microloba Salpichroa proboscidea Salpichroa ramosissima Salpichroa scandens Salpichroa tristis Salpichroa weberbauerii Solanaceae thin layer chromatography ultraviolet spectrophotometry breast tumor cell survival chemistry drug effects drug screening female isolation and purification male MCF-7 cell line metabolism pathology prostate tumor Solanaceae tumor cell line Breast Neoplasms Cell Line, Tumor Cell Survival Chromatography, Thin Layer Drug Screening Assays, Antitumor Female Humans Male MCF-7 Cells Phytochemicals Prostatic Neoplasms Solanaceae |
| spellingShingle |
Chemotaxonomic markers Cytotoxic activities Salpichroa Structure elucidation Withanolides 2,3 dihydrosalpicrolide b antineoplastic agent doxorubicin plant medicinal product salpichrolide a salpichrolide c salpichrolide d salpichrolide g salpichrolide m salpichrolide s salpichrolide t salpichrolide v unclassified drug plant medicinal product antineoplastic activity Article breast cancer cancer cell cancer chemotherapy cell density chemotaxonomy column chromatography comparative study controlled study cytotoxicity drug isolation heteronuclear multiple bond correlation heteronuclear single quantum coherence human human cell in vitro study nuclear Overhauser effect prostate carcinoma proton nuclear magnetic resonance Salpichroa Salpichroa dependens Salpichroa gayi Salpichroa glandulosa Salpichroa leucantha Salpichroa micrantha Salpichroa microloba Salpichroa proboscidea Salpichroa ramosissima Salpichroa scandens Salpichroa tristis Salpichroa weberbauerii Solanaceae thin layer chromatography ultraviolet spectrophotometry breast tumor cell survival chemistry drug effects drug screening female isolation and purification male MCF-7 cell line metabolism pathology prostate tumor Solanaceae tumor cell line Breast Neoplasms Cell Line, Tumor Cell Survival Chromatography, Thin Layer Drug Screening Assays, Antitumor Female Humans Male MCF-7 Cells Phytochemicals Prostatic Neoplasms Solanaceae Basso, A.V. Leiva González, S. Barboza, G.E. Careaga, V.P. Calvo, J.C. Sacca, P.A. Nicotra, V.E. Phytochemical Study of the Genus Salpichroa (Solanaceae), Chemotaxonomic Considerations, and Biological Evaluation in Prostate and Breast Cancer Cells |
| topic_facet |
Chemotaxonomic markers Cytotoxic activities Salpichroa Structure elucidation Withanolides 2,3 dihydrosalpicrolide b antineoplastic agent doxorubicin plant medicinal product salpichrolide a salpichrolide c salpichrolide d salpichrolide g salpichrolide m salpichrolide s salpichrolide t salpichrolide v unclassified drug plant medicinal product antineoplastic activity Article breast cancer cancer cell cancer chemotherapy cell density chemotaxonomy column chromatography comparative study controlled study cytotoxicity drug isolation heteronuclear multiple bond correlation heteronuclear single quantum coherence human human cell in vitro study nuclear Overhauser effect prostate carcinoma proton nuclear magnetic resonance Salpichroa Salpichroa dependens Salpichroa gayi Salpichroa glandulosa Salpichroa leucantha Salpichroa micrantha Salpichroa microloba Salpichroa proboscidea Salpichroa ramosissima Salpichroa scandens Salpichroa tristis Salpichroa weberbauerii Solanaceae thin layer chromatography ultraviolet spectrophotometry breast tumor cell survival chemistry drug effects drug screening female isolation and purification male MCF-7 cell line metabolism pathology prostate tumor Solanaceae tumor cell line Breast Neoplasms Cell Line, Tumor Cell Survival Chromatography, Thin Layer Drug Screening Assays, Antitumor Female Humans Male MCF-7 Cells Phytochemicals Prostatic Neoplasms Solanaceae |
| description |
Twelve Salpichroa taxa have been phytochemically analyzed. From the aerial parts of S. scandens, four known salpichrolides A, C, I, S, and an unreported withanolide named salpichrolide V (1), were isolated. In S. dependens, S. gayi, S. glandulosa subsp. glandulosa, S. glandulosa subps. weddellii, S. leucantha, S. micrantha, S. microloba, S. proboscidea, S. ramosissima, S. tristis var. tristis, and S. weberbauerii, no withanolides were found. The chemical content of ca. 85% of the Salpichroa taxa is in agreement with molecular studies, which suggest that Salpichroa and Jaborosa, a genus considered morphologically close to Salpichroa, are distant in the systematic of the Solanoideae subfamily. Moreover, the in vitro cytotoxic activity of a set of natural salpichrolides and derivatives was examined against two prostate carcinoma cell lines (PC3 and LNCaP) and two human breast cancer cell lines (MCF-7 and T47D). Several compounds showed moderate activity (IC50 = 64.91 – 29.97 μm). © 2017 Wiley-VHCA AG, Zurich, Switzerland |
| format |
JOUR |
| author |
Basso, A.V. Leiva González, S. Barboza, G.E. Careaga, V.P. Calvo, J.C. Sacca, P.A. Nicotra, V.E. |
| author_facet |
Basso, A.V. Leiva González, S. Barboza, G.E. Careaga, V.P. Calvo, J.C. Sacca, P.A. Nicotra, V.E. |
| author_sort |
Basso, A.V. |
| title |
Phytochemical Study of the Genus Salpichroa (Solanaceae), Chemotaxonomic Considerations, and Biological Evaluation in Prostate and Breast Cancer Cells |
| title_short |
Phytochemical Study of the Genus Salpichroa (Solanaceae), Chemotaxonomic Considerations, and Biological Evaluation in Prostate and Breast Cancer Cells |
| title_full |
Phytochemical Study of the Genus Salpichroa (Solanaceae), Chemotaxonomic Considerations, and Biological Evaluation in Prostate and Breast Cancer Cells |
| title_fullStr |
Phytochemical Study of the Genus Salpichroa (Solanaceae), Chemotaxonomic Considerations, and Biological Evaluation in Prostate and Breast Cancer Cells |
| title_full_unstemmed |
Phytochemical Study of the Genus Salpichroa (Solanaceae), Chemotaxonomic Considerations, and Biological Evaluation in Prostate and Breast Cancer Cells |
| title_sort |
phytochemical study of the genus salpichroa (solanaceae), chemotaxonomic considerations, and biological evaluation in prostate and breast cancer cells |
| url |
http://hdl.handle.net/20.500.12110/paper_16121872_v14_n8_p_Basso |
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