Integrating the universe of effector and regulatory immune cell subsets: An emerging role of protein-glycan interactions
The immune system has evolved as a highly effective and dynamic cellular network to signal the presence of invading pathogens and growing tumors and initiate a response that is specific for the danger signal; yet maintaining tolerance to self. In the recent years, data from genomics, proteomics and...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_15733955_v6_n4_p348_Pesoa |
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todo:paper_15733955_v6_n4_p348_Pesoa2023-10-03T16:27:35Z Integrating the universe of effector and regulatory immune cell subsets: An emerging role of protein-glycan interactions Pesoa, S.A. Croci, D.O. Rabinovich, G.A. Dendritic cells Galectins Glycoimmunology T helper cells cytokine galectin glycan growth factor article dendritic cell effector cell immunological tolerance immunomodulation immunoregulation inflammation nonhuman priority journal protein protein interaction regulatory T lymphocyte The immune system has evolved as a highly effective and dynamic cellular network to signal the presence of invading pathogens and growing tumors and initiate a response that is specific for the danger signal; yet maintaining tolerance to self. In the recent years, data from genomics, proteomics and glycomics together with classical genetic approaches (knockout and transgenic experiments) and in vivo imaging technologies revealed a complexity of immune cells and molecules which is higher than anticipated. The diversity of effector and regulatory immune cells is entering a new era, in which their specialization might contribute to the development of novel therapeutic approaches in immunopathology. In this context, recent evidence has shed light to an emerging role of protein-glycan interactions in the regulation of immune cell biology. In this review we will integrate traditional and novel subsets of immune cells and will highlight the relevance of protein-glycan systems in modulating their physiology. © 2010 Bentham Science Publishers Ltd. Fil:Croci, D.O. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_15733955_v6_n4_p348_Pesoa |
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Universidad de Buenos Aires |
| institution_str |
I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Dendritic cells Galectins Glycoimmunology T helper cells cytokine galectin glycan growth factor article dendritic cell effector cell immunological tolerance immunomodulation immunoregulation inflammation nonhuman priority journal protein protein interaction regulatory T lymphocyte |
| spellingShingle |
Dendritic cells Galectins Glycoimmunology T helper cells cytokine galectin glycan growth factor article dendritic cell effector cell immunological tolerance immunomodulation immunoregulation inflammation nonhuman priority journal protein protein interaction regulatory T lymphocyte Pesoa, S.A. Croci, D.O. Rabinovich, G.A. Integrating the universe of effector and regulatory immune cell subsets: An emerging role of protein-glycan interactions |
| topic_facet |
Dendritic cells Galectins Glycoimmunology T helper cells cytokine galectin glycan growth factor article dendritic cell effector cell immunological tolerance immunomodulation immunoregulation inflammation nonhuman priority journal protein protein interaction regulatory T lymphocyte |
| description |
The immune system has evolved as a highly effective and dynamic cellular network to signal the presence of invading pathogens and growing tumors and initiate a response that is specific for the danger signal; yet maintaining tolerance to self. In the recent years, data from genomics, proteomics and glycomics together with classical genetic approaches (knockout and transgenic experiments) and in vivo imaging technologies revealed a complexity of immune cells and molecules which is higher than anticipated. The diversity of effector and regulatory immune cells is entering a new era, in which their specialization might contribute to the development of novel therapeutic approaches in immunopathology. In this context, recent evidence has shed light to an emerging role of protein-glycan interactions in the regulation of immune cell biology. In this review we will integrate traditional and novel subsets of immune cells and will highlight the relevance of protein-glycan systems in modulating their physiology. © 2010 Bentham Science Publishers Ltd. |
| format |
JOUR |
| author |
Pesoa, S.A. Croci, D.O. Rabinovich, G.A. |
| author_facet |
Pesoa, S.A. Croci, D.O. Rabinovich, G.A. |
| author_sort |
Pesoa, S.A. |
| title |
Integrating the universe of effector and regulatory immune cell subsets: An emerging role of protein-glycan interactions |
| title_short |
Integrating the universe of effector and regulatory immune cell subsets: An emerging role of protein-glycan interactions |
| title_full |
Integrating the universe of effector and regulatory immune cell subsets: An emerging role of protein-glycan interactions |
| title_fullStr |
Integrating the universe of effector and regulatory immune cell subsets: An emerging role of protein-glycan interactions |
| title_full_unstemmed |
Integrating the universe of effector and regulatory immune cell subsets: An emerging role of protein-glycan interactions |
| title_sort |
integrating the universe of effector and regulatory immune cell subsets: an emerging role of protein-glycan interactions |
| url |
http://hdl.handle.net/20.500.12110/paper_15733955_v6_n4_p348_Pesoa |
| work_keys_str_mv |
AT pesoasa integratingtheuniverseofeffectorandregulatoryimmunecellsubsetsanemergingroleofproteinglycaninteractions AT crocido integratingtheuniverseofeffectorandregulatoryimmunecellsubsetsanemergingroleofproteinglycaninteractions AT rabinovichga integratingtheuniverseofeffectorandregulatoryimmunecellsubsetsanemergingroleofproteinglycaninteractions |
| _version_ |
1807323427637297152 |