The benefits of analysing complete mitochondrial genomes: Deep insights into the phylogeny and population structure of Echinococcus granulosus sensu lato genotypes G6 and G7
Cystic echinococcosis (CE) is a zoonotic disease caused by the larval stage of the species complex Echinococcus granulosus sensu lato. Within this complex, genotypes G6 and G7 have been frequently associated with human CE worldwide. Previous studies exploring the genetic variability and phylogeograp...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | JOUR |
| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_15671348_v64_n_p85_Laurimae |
| Aporte de: |
| id |
todo:paper_15671348_v64_n_p85_Laurimae |
|---|---|
| record_format |
dspace |
| spelling |
todo:paper_15671348_v64_n_p85_Laurimae2023-10-03T16:26:32Z The benefits of analysing complete mitochondrial genomes: Deep insights into the phylogeny and population structure of Echinococcus granulosus sensu lato genotypes G6 and G7 Laurimäe, T. Kinkar, L. Romig, T. Omer, R.A. Casulli, A. Umhang, G. Gasser, R.B. Jabbar, A. Sharbatkhori, M. Mirhendi, H. Ponce-Gordo, F. Lazzarini, L.E. Soriano, S.V. Varcasia, A. Rostami Nejad, M. Andresiuk, V. Maravilla, P. González, L.M. Dybicz, M. Gawor, J. Šarkūnas, M. Šnábel, V. Kuzmina, T. Saarma, U. Cystic echinococcosis Genotype G6 Genotype G7 Hydatid disease Mitochondrial genome Zoonosis cyclooxygenase 1 Article binding affinity Corsica Echinococcus granulosus Echinococcus granulosus sensu lato gene sequence gene structure genetic variability genetic variation genotype geographic mapping geography haplotype human life cycle mitochondrial genome Mongolia nonhuman phylogeny population differentiation population structure priority journal Sardinia sequence analysis Cystic echinococcosis (CE) is a zoonotic disease caused by the larval stage of the species complex Echinococcus granulosus sensu lato. Within this complex, genotypes G6 and G7 have been frequently associated with human CE worldwide. Previous studies exploring the genetic variability and phylogeography of genotypes G6 and G7 have been based on relatively short mtDNA sequences, and the resolution of these studies has often been low. Moreover, using short sequences, the distinction between G6 and G7 has in some cases remained challenging. The aim here was to sequence complete mitochondrial genomes (mitogenomes) to obtain deeper insight into the genetic diversity, phylogeny and population structure of genotypes G6 and G7. We sequenced complete mitogenomes of 94 samples collected from 15 different countries worldwide. The results demonstrated that (i) genotypes G6 and G7 can be clearly distinguished when mitogenome sequences are used; (ii) G7 is represented by two major haplogroups, G7a and G7b, the latter being specific to islands of Corsica and Sardinia; (iii) intensive animal trade, but also geographical isolation, have likely had the largest impact on shaping the genetic structure and distribution of genotypes G6 and G7. In addition, we found phylogenetically highly divergent haplotype from Mongolia (Gmon), which had a higher affinity to G6. © 2018 Elsevier B.V. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_15671348_v64_n_p85_Laurimae |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Cystic echinococcosis Genotype G6 Genotype G7 Hydatid disease Mitochondrial genome Zoonosis cyclooxygenase 1 Article binding affinity Corsica Echinococcus granulosus Echinococcus granulosus sensu lato gene sequence gene structure genetic variability genetic variation genotype geographic mapping geography haplotype human life cycle mitochondrial genome Mongolia nonhuman phylogeny population differentiation population structure priority journal Sardinia sequence analysis |
| spellingShingle |
Cystic echinococcosis Genotype G6 Genotype G7 Hydatid disease Mitochondrial genome Zoonosis cyclooxygenase 1 Article binding affinity Corsica Echinococcus granulosus Echinococcus granulosus sensu lato gene sequence gene structure genetic variability genetic variation genotype geographic mapping geography haplotype human life cycle mitochondrial genome Mongolia nonhuman phylogeny population differentiation population structure priority journal Sardinia sequence analysis Laurimäe, T. Kinkar, L. Romig, T. Omer, R.A. Casulli, A. Umhang, G. Gasser, R.B. Jabbar, A. Sharbatkhori, M. Mirhendi, H. Ponce-Gordo, F. Lazzarini, L.E. Soriano, S.V. Varcasia, A. Rostami Nejad, M. Andresiuk, V. Maravilla, P. González, L.M. Dybicz, M. Gawor, J. Šarkūnas, M. Šnábel, V. Kuzmina, T. Saarma, U. The benefits of analysing complete mitochondrial genomes: Deep insights into the phylogeny and population structure of Echinococcus granulosus sensu lato genotypes G6 and G7 |
| topic_facet |
Cystic echinococcosis Genotype G6 Genotype G7 Hydatid disease Mitochondrial genome Zoonosis cyclooxygenase 1 Article binding affinity Corsica Echinococcus granulosus Echinococcus granulosus sensu lato gene sequence gene structure genetic variability genetic variation genotype geographic mapping geography haplotype human life cycle mitochondrial genome Mongolia nonhuman phylogeny population differentiation population structure priority journal Sardinia sequence analysis |
| description |
Cystic echinococcosis (CE) is a zoonotic disease caused by the larval stage of the species complex Echinococcus granulosus sensu lato. Within this complex, genotypes G6 and G7 have been frequently associated with human CE worldwide. Previous studies exploring the genetic variability and phylogeography of genotypes G6 and G7 have been based on relatively short mtDNA sequences, and the resolution of these studies has often been low. Moreover, using short sequences, the distinction between G6 and G7 has in some cases remained challenging. The aim here was to sequence complete mitochondrial genomes (mitogenomes) to obtain deeper insight into the genetic diversity, phylogeny and population structure of genotypes G6 and G7. We sequenced complete mitogenomes of 94 samples collected from 15 different countries worldwide. The results demonstrated that (i) genotypes G6 and G7 can be clearly distinguished when mitogenome sequences are used; (ii) G7 is represented by two major haplogroups, G7a and G7b, the latter being specific to islands of Corsica and Sardinia; (iii) intensive animal trade, but also geographical isolation, have likely had the largest impact on shaping the genetic structure and distribution of genotypes G6 and G7. In addition, we found phylogenetically highly divergent haplotype from Mongolia (Gmon), which had a higher affinity to G6. © 2018 Elsevier B.V. |
| format |
JOUR |
| author |
Laurimäe, T. Kinkar, L. Romig, T. Omer, R.A. Casulli, A. Umhang, G. Gasser, R.B. Jabbar, A. Sharbatkhori, M. Mirhendi, H. Ponce-Gordo, F. Lazzarini, L.E. Soriano, S.V. Varcasia, A. Rostami Nejad, M. Andresiuk, V. Maravilla, P. González, L.M. Dybicz, M. Gawor, J. Šarkūnas, M. Šnábel, V. Kuzmina, T. Saarma, U. |
| author_facet |
Laurimäe, T. Kinkar, L. Romig, T. Omer, R.A. Casulli, A. Umhang, G. Gasser, R.B. Jabbar, A. Sharbatkhori, M. Mirhendi, H. Ponce-Gordo, F. Lazzarini, L.E. Soriano, S.V. Varcasia, A. Rostami Nejad, M. Andresiuk, V. Maravilla, P. González, L.M. Dybicz, M. Gawor, J. Šarkūnas, M. Šnábel, V. Kuzmina, T. Saarma, U. |
| author_sort |
Laurimäe, T. |
| title |
The benefits of analysing complete mitochondrial genomes: Deep insights into the phylogeny and population structure of Echinococcus granulosus sensu lato genotypes G6 and G7 |
| title_short |
The benefits of analysing complete mitochondrial genomes: Deep insights into the phylogeny and population structure of Echinococcus granulosus sensu lato genotypes G6 and G7 |
| title_full |
The benefits of analysing complete mitochondrial genomes: Deep insights into the phylogeny and population structure of Echinococcus granulosus sensu lato genotypes G6 and G7 |
| title_fullStr |
The benefits of analysing complete mitochondrial genomes: Deep insights into the phylogeny and population structure of Echinococcus granulosus sensu lato genotypes G6 and G7 |
| title_full_unstemmed |
The benefits of analysing complete mitochondrial genomes: Deep insights into the phylogeny and population structure of Echinococcus granulosus sensu lato genotypes G6 and G7 |
| title_sort |
benefits of analysing complete mitochondrial genomes: deep insights into the phylogeny and population structure of echinococcus granulosus sensu lato genotypes g6 and g7 |
| url |
http://hdl.handle.net/20.500.12110/paper_15671348_v64_n_p85_Laurimae |
| work_keys_str_mv |
AT laurimaet thebenefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT kinkarl thebenefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT romigt thebenefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT omerra thebenefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT casullia thebenefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT umhangg thebenefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT gasserrb thebenefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT jabbara thebenefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT sharbatkhorim thebenefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT mirhendih thebenefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT poncegordof thebenefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT lazzarinile thebenefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT sorianosv thebenefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT varcasiaa thebenefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT rostaminejadm thebenefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT andresiukv thebenefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT maravillap thebenefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT gonzalezlm thebenefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT dybiczm thebenefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT gaworj thebenefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT sarkunasm thebenefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT snabelv thebenefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT kuzminat thebenefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT saarmau thebenefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT laurimaet benefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT kinkarl benefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT romigt benefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT omerra benefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT casullia benefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT umhangg benefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT gasserrb benefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT jabbara benefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT sharbatkhorim benefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT mirhendih benefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT poncegordof benefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT lazzarinile benefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT sorianosv benefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT varcasiaa benefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT rostaminejadm benefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT andresiukv benefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT maravillap benefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT gonzalezlm benefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT dybiczm benefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT gaworj benefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT sarkunasm benefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT snabelv benefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT kuzminat benefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 AT saarmau benefitsofanalysingcompletemitochondrialgenomesdeepinsightsintothephylogenyandpopulationstructureofechinococcusgranulosussensulatogenotypesg6andg7 |
| _version_ |
1807318557926621184 |