The revised Trypanosoma cruzi subspecific nomenclature: Rationale, epidemiological relevance and research applications
The protozoan Trypanosoma cruzi, its mammalian reservoirs, and vectors have existed in nature for millions of years. The human infection, named Chagas disease, is a major public health problem for Latin America. T. cruzi is genetically highly diverse and the understanding of the population structure...
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todo:paper_15671348_v12_n2_p240_Zingales2023-10-03T16:26:29Z The revised Trypanosoma cruzi subspecific nomenclature: Rationale, epidemiological relevance and research applications Zingales, B. Miles, M.A. Campbell, D.A. Tibayrenc, M. Macedo, A.M. Teixeira, M.M.G. Schijman, A.G. Llewellyn, M.S. Lages-Silva, E. Machado, C.R. Andrade, S.G. Sturm, N.R. Discrete typing unit Genotyping Hybridization Pathology Phylogeography Trypanosoma cruzi strains ribosome DNA clinical feature disease transmission gene frequency genetic variability genome analysis genotype geographic distribution heterozygosity human mitochondrial genome multilocus sequence typing nonhuman phylogeography population research population structure priority journal review single nucleotide polymorphism taxonomy Trypanosoma cruzi Animals Chagas Disease Chiroptera Evolution, Molecular Genetic Variation Genome, Protozoan Genomics Humans Multilocus Sequence Typing Phylogeography Terminology as Topic Trypanosoma cruzi Mammalia Protozoa Trypanosoma cruzi The protozoan Trypanosoma cruzi, its mammalian reservoirs, and vectors have existed in nature for millions of years. The human infection, named Chagas disease, is a major public health problem for Latin America. T. cruzi is genetically highly diverse and the understanding of the population structure of this parasite is critical because of the links to transmission cycles and disease. At present, T. cruzi is partitioned into six discrete typing units (DTUs), TcI-TcVI. Here we focus on the current status of taxonomy-related areas such as population structure, phylogeographical and eco-epidemiological features, and the correlation of DTU with natural and experimental infection. We also summarize methods for DTU genotyping, available for widespread use in endemic areas. For the immediate future multilocus sequence typing is likely to be the gold standard for population studies. We conclude that greater advances in our knowledge on pathogenic and epidemiological features of these parasites are expected in the coming decade through the comparative analysis of the genomes from isolates of various DTUs. © 2012 Elsevier B.V. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_15671348_v12_n2_p240_Zingales |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Discrete typing unit Genotyping Hybridization Pathology Phylogeography Trypanosoma cruzi strains ribosome DNA clinical feature disease transmission gene frequency genetic variability genome analysis genotype geographic distribution heterozygosity human mitochondrial genome multilocus sequence typing nonhuman phylogeography population research population structure priority journal review single nucleotide polymorphism taxonomy Trypanosoma cruzi Animals Chagas Disease Chiroptera Evolution, Molecular Genetic Variation Genome, Protozoan Genomics Humans Multilocus Sequence Typing Phylogeography Terminology as Topic Trypanosoma cruzi Mammalia Protozoa Trypanosoma cruzi |
| spellingShingle |
Discrete typing unit Genotyping Hybridization Pathology Phylogeography Trypanosoma cruzi strains ribosome DNA clinical feature disease transmission gene frequency genetic variability genome analysis genotype geographic distribution heterozygosity human mitochondrial genome multilocus sequence typing nonhuman phylogeography population research population structure priority journal review single nucleotide polymorphism taxonomy Trypanosoma cruzi Animals Chagas Disease Chiroptera Evolution, Molecular Genetic Variation Genome, Protozoan Genomics Humans Multilocus Sequence Typing Phylogeography Terminology as Topic Trypanosoma cruzi Mammalia Protozoa Trypanosoma cruzi Zingales, B. Miles, M.A. Campbell, D.A. Tibayrenc, M. Macedo, A.M. Teixeira, M.M.G. Schijman, A.G. Llewellyn, M.S. Lages-Silva, E. Machado, C.R. Andrade, S.G. Sturm, N.R. The revised Trypanosoma cruzi subspecific nomenclature: Rationale, epidemiological relevance and research applications |
| topic_facet |
Discrete typing unit Genotyping Hybridization Pathology Phylogeography Trypanosoma cruzi strains ribosome DNA clinical feature disease transmission gene frequency genetic variability genome analysis genotype geographic distribution heterozygosity human mitochondrial genome multilocus sequence typing nonhuman phylogeography population research population structure priority journal review single nucleotide polymorphism taxonomy Trypanosoma cruzi Animals Chagas Disease Chiroptera Evolution, Molecular Genetic Variation Genome, Protozoan Genomics Humans Multilocus Sequence Typing Phylogeography Terminology as Topic Trypanosoma cruzi Mammalia Protozoa Trypanosoma cruzi |
| description |
The protozoan Trypanosoma cruzi, its mammalian reservoirs, and vectors have existed in nature for millions of years. The human infection, named Chagas disease, is a major public health problem for Latin America. T. cruzi is genetically highly diverse and the understanding of the population structure of this parasite is critical because of the links to transmission cycles and disease. At present, T. cruzi is partitioned into six discrete typing units (DTUs), TcI-TcVI. Here we focus on the current status of taxonomy-related areas such as population structure, phylogeographical and eco-epidemiological features, and the correlation of DTU with natural and experimental infection. We also summarize methods for DTU genotyping, available for widespread use in endemic areas. For the immediate future multilocus sequence typing is likely to be the gold standard for population studies. We conclude that greater advances in our knowledge on pathogenic and epidemiological features of these parasites are expected in the coming decade through the comparative analysis of the genomes from isolates of various DTUs. © 2012 Elsevier B.V. |
| format |
JOUR |
| author |
Zingales, B. Miles, M.A. Campbell, D.A. Tibayrenc, M. Macedo, A.M. Teixeira, M.M.G. Schijman, A.G. Llewellyn, M.S. Lages-Silva, E. Machado, C.R. Andrade, S.G. Sturm, N.R. |
| author_facet |
Zingales, B. Miles, M.A. Campbell, D.A. Tibayrenc, M. Macedo, A.M. Teixeira, M.M.G. Schijman, A.G. Llewellyn, M.S. Lages-Silva, E. Machado, C.R. Andrade, S.G. Sturm, N.R. |
| author_sort |
Zingales, B. |
| title |
The revised Trypanosoma cruzi subspecific nomenclature: Rationale, epidemiological relevance and research applications |
| title_short |
The revised Trypanosoma cruzi subspecific nomenclature: Rationale, epidemiological relevance and research applications |
| title_full |
The revised Trypanosoma cruzi subspecific nomenclature: Rationale, epidemiological relevance and research applications |
| title_fullStr |
The revised Trypanosoma cruzi subspecific nomenclature: Rationale, epidemiological relevance and research applications |
| title_full_unstemmed |
The revised Trypanosoma cruzi subspecific nomenclature: Rationale, epidemiological relevance and research applications |
| title_sort |
revised trypanosoma cruzi subspecific nomenclature: rationale, epidemiological relevance and research applications |
| url |
http://hdl.handle.net/20.500.12110/paper_15671348_v12_n2_p240_Zingales |
| work_keys_str_mv |
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