Modification of Akt by SUMO conjugation regulates alternative splicing and cell cycle

Akt/PKB is a key signaling molecule in higher eukaryotes and a crucial protein kinase in human health and disease. Phosphorylation, acetylation, and ubiquitylation have been reported as important regulatory post-translational modifications of this kinase. We describe here that Akt is modified by SUM...

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Detalles Bibliográficos
Autores principales: Risso, G., Pelisch, F., Pozzi, B., Mammi, P., Blaustein, M., Colman-Lerner, A., Srebrow, A.
Formato: JOUR
Materias:
Akt/PKB
Alternative splicing
Cell cycle
Post-translational modification
Signal transduction
SUMO
fibronectin
protein bcl x
protein kinase B
SUMO 2 protein
SUMO protein
acetylation
alternative RNA splicing
article
cell cycle
cell cycle G1 phase
cell cycle progression
cell cycle S phase
cell function
conjugation
enzyme activity
human
protein function
protein phosphorylation
sumoylation
ubiquitination
Eukaryota
alternative splicing
post-translational modification
signal transduction
Alternative Splicing
bcl-X Protein
Fibronectins
G1 Phase
HEK293 Cells
HeLa Cells
Humans
Mutagenesis, Site-Directed
Phosphorylation
Proto-Oncogene Proteins c-akt
RNA Interference
RNA, Small Interfering
S Phase
Small Ubiquitin-Related Modifier Proteins
Sumoylation
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_15384101_v12_n19_p3165_Risso
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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