Protective action of antioxidants on hepatic damage induced by griseofulvin

Erythropoietic protoporphyria (EPP) is a disease associated with ferrochelatase deficiency and characterized by the accumulation of protoporphyrin IX (PROTO IX) in erythrocytes, liver, and skin. In some cases, a severe hepatic failure and cholestasis were observed. Griseofulvin (Gris) develops an ex...

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Detalles Bibliográficos
Autores principales: Martinez, M.D.C., Afonso, S.G., Buzaleh, A.M., Batlle, A.
Formato: JOUR
Materias:
antifungal agent
antioxidant
biological marker
glutathione
griseofulvin
heme
superoxide dismutase
animal
article
disease model
male
metabolism
mouse
toxic hepatitis
Animals
Antifungal Agents
Antioxidants
Biological Markers
Disease Models, Animal
Drug-Induced Liver Injury
Glutathione
Griseofulvin
Heme
Male
Mice
Superoxide Dismutase
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_1537744X_v2014_n_p_Martinez
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_1537744X_v2014_n_p_Martinez
record_format dspace
spelling todo:paper_1537744X_v2014_n_p_Martinez2023-10-03T16:21:55Z Protective action of antioxidants on hepatic damage induced by griseofulvin Martinez, M.D.C. Afonso, S.G. Buzaleh, A.M. Batlle, A. antifungal agent antioxidant biological marker glutathione griseofulvin heme superoxide dismutase animal article disease model male metabolism mouse toxic hepatitis Animals Antifungal Agents Antioxidants Biological Markers Disease Models, Animal Drug-Induced Liver Injury Glutathione Griseofulvin Heme Male Mice Superoxide Dismutase Erythropoietic protoporphyria (EPP) is a disease associated with ferrochelatase deficiency and characterized by the accumulation of protoporphyrin IX (PROTO IX) in erythrocytes, liver, and skin. In some cases, a severe hepatic failure and cholestasis were observed. Griseofulvin (Gris) develops an experimental EPP with hepatic manifestations in mice such as PROTO IX accumulation followed by cellular damage as wells as necrotic and inflammatory processes. The antioxidant defense system was also altered. The aim was to evaluate the possible protective effect of different antioxidant compounds: trolox (Tx), ascorbic acid (Asc), the combination Tx and Asc, melatonin (Mel), and the polyphenols: ellagic acid, quercetin, chlorogenic acid, caffeic acid, gallic acid, and ferulic acid on liver damage and oxidative stress markers in a mouse model of EPP. Coadministration of Gris with Tx, Asc, and its combination, or Mel mainly affected heme biosynthetic pathway, resulting in a decrease in ALA-S activity which was increased by Gris, while the tested polyphenols exerted a protective effect on oxidative stress, decreasing lipid peroxidation and the activity of some antioxidant enzymes. In conclusion, antioxidant compounds can only protect partially against the liver damage induced by Gris, reducing oxidative stress or acting on heme regulation. © 2014 M. del C. Martinez et al. Fil:Martinez, M.D.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Afonso, S.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Buzaleh, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Batlle, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_1537744X_v2014_n_p_Martinez
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic antifungal agent
antioxidant
biological marker
glutathione
griseofulvin
heme
superoxide dismutase
animal
article
disease model
male
metabolism
mouse
toxic hepatitis
Animals
Antifungal Agents
Antioxidants
Biological Markers
Disease Models, Animal
Drug-Induced Liver Injury
Glutathione
Griseofulvin
Heme
Male
Mice
Superoxide Dismutase
spellingShingle antifungal agent
antioxidant
biological marker
glutathione
griseofulvin
heme
superoxide dismutase
animal
article
disease model
male
metabolism
mouse
toxic hepatitis
Animals
Antifungal Agents
Antioxidants
Biological Markers
Disease Models, Animal
Drug-Induced Liver Injury
Glutathione
Griseofulvin
Heme
Male
Mice
Superoxide Dismutase
Martinez, M.D.C.
Afonso, S.G.
Buzaleh, A.M.
Batlle, A.
Protective action of antioxidants on hepatic damage induced by griseofulvin
topic_facet antifungal agent
antioxidant
biological marker
glutathione
griseofulvin
heme
superoxide dismutase
animal
article
disease model
male
metabolism
mouse
toxic hepatitis
Animals
Antifungal Agents
Antioxidants
Biological Markers
Disease Models, Animal
Drug-Induced Liver Injury
Glutathione
Griseofulvin
Heme
Male
Mice
Superoxide Dismutase
description Erythropoietic protoporphyria (EPP) is a disease associated with ferrochelatase deficiency and characterized by the accumulation of protoporphyrin IX (PROTO IX) in erythrocytes, liver, and skin. In some cases, a severe hepatic failure and cholestasis were observed. Griseofulvin (Gris) develops an experimental EPP with hepatic manifestations in mice such as PROTO IX accumulation followed by cellular damage as wells as necrotic and inflammatory processes. The antioxidant defense system was also altered. The aim was to evaluate the possible protective effect of different antioxidant compounds: trolox (Tx), ascorbic acid (Asc), the combination Tx and Asc, melatonin (Mel), and the polyphenols: ellagic acid, quercetin, chlorogenic acid, caffeic acid, gallic acid, and ferulic acid on liver damage and oxidative stress markers in a mouse model of EPP. Coadministration of Gris with Tx, Asc, and its combination, or Mel mainly affected heme biosynthetic pathway, resulting in a decrease in ALA-S activity which was increased by Gris, while the tested polyphenols exerted a protective effect on oxidative stress, decreasing lipid peroxidation and the activity of some antioxidant enzymes. In conclusion, antioxidant compounds can only protect partially against the liver damage induced by Gris, reducing oxidative stress or acting on heme regulation. © 2014 M. del C. Martinez et al.
format JOUR
author Martinez, M.D.C.
Afonso, S.G.
Buzaleh, A.M.
Batlle, A.
author_facet Martinez, M.D.C.
Afonso, S.G.
Buzaleh, A.M.
Batlle, A.
author_sort Martinez, M.D.C.
title Protective action of antioxidants on hepatic damage induced by griseofulvin
title_short Protective action of antioxidants on hepatic damage induced by griseofulvin
title_full Protective action of antioxidants on hepatic damage induced by griseofulvin
title_fullStr Protective action of antioxidants on hepatic damage induced by griseofulvin
title_full_unstemmed Protective action of antioxidants on hepatic damage induced by griseofulvin
title_sort protective action of antioxidants on hepatic damage induced by griseofulvin
url http://hdl.handle.net/20.500.12110/paper_1537744X_v2014_n_p_Martinez
work_keys_str_mv AT martinezmdc protectiveactionofantioxidantsonhepaticdamageinducedbygriseofulvin
AT afonsosg protectiveactionofantioxidantsonhepaticdamageinducedbygriseofulvin
AT buzaleham protectiveactionofantioxidantsonhepaticdamageinducedbygriseofulvin
AT batllea protectiveactionofantioxidantsonhepaticdamageinducedbygriseofulvin
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