Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10

Despite their central function in orchestrating immunity, dendritic cells (DCs) can respond to inhibitory signals by becoming tolerogenic. Here we show that galectin-1, an endogenous glycan-binding protein, can endow DCs with tolerogenic potential. After exposure to galectin-1, DCs acquired an inter...

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Autores principales:	Ilarregui, J.M., Croci, D.O., Bianco, G.A., Toscano, M.A., Salatino, M., Vermeulen, M.E., Geffner, J.R., Rabinovich, G.A.
Formato:	JOUR
Materias:	galectin 1 gamma interferon granulocyte macrophage colony stimulating factor interleukin 10 interleukin 27 ovalbumin animal cell antiinflammatory activity article CD4+ T lymphocyte cell differentiation cell stimulation controlled study cytokine production cytokine release dendritic cell human human cell immunological tolerance immunoregulation inflammation mouse nonhuman priority journal protein expression protein function protein localization signal transduction T lymphocyte upregulation Animals Antigens, CD40 Dendritic Cells Encephalomyelitis, Autoimmune, Experimental Female Galectin 1 Gene Expression Regulation Glycoproteins Immune Tolerance Interleukin-10 Interleukins Mice Mice, Inbred BALB C Mice, Inbred C57BL Peptide Fragments STAT3 Transcription Factor T-Lymphocytes
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_15292908_v10_n9_p981_Ilarregui
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_15292908_v10_n9_p981_Ilarregui
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spelling	todo:paper_15292908_v10_n9_p981_Ilarregui2023-10-03T16:21:11Z Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10 Ilarregui, J.M. Croci, D.O. Bianco, G.A. Toscano, M.A. Salatino, M. Vermeulen, M.E. Geffner, J.R. Rabinovich, G.A. galectin 1 gamma interferon granulocyte macrophage colony stimulating factor interleukin 10 interleukin 27 ovalbumin animal cell antiinflammatory activity article CD4+ T lymphocyte cell differentiation cell stimulation controlled study cytokine production cytokine release dendritic cell human human cell immunological tolerance immunoregulation inflammation mouse nonhuman priority journal protein expression protein function protein localization signal transduction T lymphocyte upregulation Animals Antigens, CD40 Dendritic Cells Encephalomyelitis, Autoimmune, Experimental Female Galectin 1 Gene Expression Regulation Glycoproteins Immune Tolerance Interleukin-10 Interleukins Mice Mice, Inbred BALB C Mice, Inbred C57BL Peptide Fragments STAT3 Transcription Factor T-Lymphocytes Despite their central function in orchestrating immunity, dendritic cells (DCs) can respond to inhibitory signals by becoming tolerogenic. Here we show that galectin-1, an endogenous glycan-binding protein, can endow DCs with tolerogenic potential. After exposure to galectin-1, DCs acquired an interleukin 27 (IL-27)-dependent regulatory function, promoted IL-10-mediated T cell tolerance and suppressed autoimmune neuroinflammation. Consistent with its regulatory function, galectin-1 had its highest expression on DCs exposed to tolerogenic stimuli and was most abundant from the peak through the resolution of autoimmune pathology. DCs lacking galectin-1 had greater immunogenic potential and an impaired ability to halt inflammatory disease. Our findings identify a tolerogenic circuit linking galectin-1 signaling, IL-27-producing DCs and IL-10-secreting T cells, which has broad therapeutic implications in immunopathology. Fil:Ilarregui, J.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Croci, D.O. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Toscano, M.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Salatino, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Vermeulen, M.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_15292908_v10_n9_p981_Ilarregui
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	galectin 1 gamma interferon granulocyte macrophage colony stimulating factor interleukin 10 interleukin 27 ovalbumin animal cell antiinflammatory activity article CD4+ T lymphocyte cell differentiation cell stimulation controlled study cytokine production cytokine release dendritic cell human human cell immunological tolerance immunoregulation inflammation mouse nonhuman priority journal protein expression protein function protein localization signal transduction T lymphocyte upregulation Animals Antigens, CD40 Dendritic Cells Encephalomyelitis, Autoimmune, Experimental Female Galectin 1 Gene Expression Regulation Glycoproteins Immune Tolerance Interleukin-10 Interleukins Mice Mice, Inbred BALB C Mice, Inbred C57BL Peptide Fragments STAT3 Transcription Factor T-Lymphocytes
spellingShingle	galectin 1 gamma interferon granulocyte macrophage colony stimulating factor interleukin 10 interleukin 27 ovalbumin animal cell antiinflammatory activity article CD4+ T lymphocyte cell differentiation cell stimulation controlled study cytokine production cytokine release dendritic cell human human cell immunological tolerance immunoregulation inflammation mouse nonhuman priority journal protein expression protein function protein localization signal transduction T lymphocyte upregulation Animals Antigens, CD40 Dendritic Cells Encephalomyelitis, Autoimmune, Experimental Female Galectin 1 Gene Expression Regulation Glycoproteins Immune Tolerance Interleukin-10 Interleukins Mice Mice, Inbred BALB C Mice, Inbred C57BL Peptide Fragments STAT3 Transcription Factor T-Lymphocytes Ilarregui, J.M. Croci, D.O. Bianco, G.A. Toscano, M.A. Salatino, M. Vermeulen, M.E. Geffner, J.R. Rabinovich, G.A. Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10
topic_facet	galectin 1 gamma interferon granulocyte macrophage colony stimulating factor interleukin 10 interleukin 27 ovalbumin animal cell antiinflammatory activity article CD4+ T lymphocyte cell differentiation cell stimulation controlled study cytokine production cytokine release dendritic cell human human cell immunological tolerance immunoregulation inflammation mouse nonhuman priority journal protein expression protein function protein localization signal transduction T lymphocyte upregulation Animals Antigens, CD40 Dendritic Cells Encephalomyelitis, Autoimmune, Experimental Female Galectin 1 Gene Expression Regulation Glycoproteins Immune Tolerance Interleukin-10 Interleukins Mice Mice, Inbred BALB C Mice, Inbred C57BL Peptide Fragments STAT3 Transcription Factor T-Lymphocytes
description	Despite their central function in orchestrating immunity, dendritic cells (DCs) can respond to inhibitory signals by becoming tolerogenic. Here we show that galectin-1, an endogenous glycan-binding protein, can endow DCs with tolerogenic potential. After exposure to galectin-1, DCs acquired an interleukin 27 (IL-27)-dependent regulatory function, promoted IL-10-mediated T cell tolerance and suppressed autoimmune neuroinflammation. Consistent with its regulatory function, galectin-1 had its highest expression on DCs exposed to tolerogenic stimuli and was most abundant from the peak through the resolution of autoimmune pathology. DCs lacking galectin-1 had greater immunogenic potential and an impaired ability to halt inflammatory disease. Our findings identify a tolerogenic circuit linking galectin-1 signaling, IL-27-producing DCs and IL-10-secreting T cells, which has broad therapeutic implications in immunopathology.
format	JOUR
author	Ilarregui, J.M. Croci, D.O. Bianco, G.A. Toscano, M.A. Salatino, M. Vermeulen, M.E. Geffner, J.R. Rabinovich, G.A.
author_facet	Ilarregui, J.M. Croci, D.O. Bianco, G.A. Toscano, M.A. Salatino, M. Vermeulen, M.E. Geffner, J.R. Rabinovich, G.A.
author_sort	Ilarregui, J.M.
title	Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10
title_short	Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10
title_full	Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10
title_fullStr	Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10
title_full_unstemmed	Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10
title_sort	tolerogenic signals delivered by dendritic cells to t cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10
url	http://hdl.handle.net/20.500.12110/paper_15292908_v10_n9_p981_Ilarregui
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Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10

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