Interaction of p53 with tumor suppressive and oncogenic signaling pathways to control cellular reactive oxygen species production

p53 is a crucial transcription factor with tumor suppressive properties that elicits its function through specific target genes. It constitutes a pivotal system that integrates information received by many signaling pathways and subsequently orchestrates cell fate decisions, namely, growth-arrest, s...

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Autores principales:	Ladelfa, M.F., Toledo, M.F., Laiseca, J.E., Monte, M.
Formato:	JOUR
Materias:	beta catenin hypoxia inducible factor mammalian target of rapamycin mitogen activated protein kinase phosphatidylinositol 3 kinase protein kinase B protein p53 reactive oxygen metabolite Smad protein stress activated protein kinase transforming growth factor beta Wnt protein apoptosis cell proliferation human hypoxia metabolic regulation nonhuman priority journal protein function review signal transduction Apoptosis Genomic Instability Humans Hypoxia-Inducible Factor 1, alpha Subunit Mitogen-Activated Protein Kinases Neoplasms Oncogenes Reactive Oxygen Species Signal Transduction TOR Serine-Threonine Kinases Transforming Growth Factor beta Tumor Suppressor Protein p53 Wnt Proteins
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_15230864_v15_n6_p1749_Ladelfa
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_15230864_v15_n6_p1749_Ladelfa
record_format	dspace
spelling	todo:paper_15230864_v15_n6_p1749_Ladelfa2023-10-03T16:20:49Z Interaction of p53 with tumor suppressive and oncogenic signaling pathways to control cellular reactive oxygen species production Ladelfa, M.F. Toledo, M.F. Laiseca, J.E. Monte, M. beta catenin hypoxia inducible factor mammalian target of rapamycin mitogen activated protein kinase phosphatidylinositol 3 kinase protein kinase B protein p53 reactive oxygen metabolite Smad protein stress activated protein kinase transforming growth factor beta Wnt protein apoptosis cell proliferation human hypoxia metabolic regulation nonhuman priority journal protein function review signal transduction Apoptosis Genomic Instability Humans Hypoxia-Inducible Factor 1, alpha Subunit Mitogen-Activated Protein Kinases Neoplasms Oncogenes Reactive Oxygen Species Signal Transduction TOR Serine-Threonine Kinases Transforming Growth Factor beta Tumor Suppressor Protein p53 Wnt Proteins p53 is a crucial transcription factor with tumor suppressive properties that elicits its function through specific target genes. It constitutes a pivotal system that integrates information received by many signaling pathways and subsequently orchestrates cell fate decisions, namely, growth-arrest, senescence, or apoptosis. Reactive oxygen species (ROS) production in cells can play a key role in signal transduction, being able to trigger different processes as cell death or cell proliferation. Sustained oxidative stress can induce genomic instability and collaborates with cancer development, whereas acute enhancement of high ROS levels leads to toxic oxidative cell damage and cell death. Here, it has been considered p53 broad potential contribution through its ability to regulate selected key cancer signaling pathways, where ROS participate as inductors or effectors of the final biological outcome. Further, we have discussed how p53 could play a role in preventing potentially harmful oxidative state and cell proliferation by pro-oncogenic pathways such as PI3K/AKT/mTOR and WNT/β-catenin or under hypoxia state. In addition, we have considered potential mechanisms by which p53 could collaborate with signal transduction pathways such as transforming growth factor-β (TGF-β) and stress-activated protein kinases (SAPK) that produce ROS, to stop or eliminate uncontrolled proliferating cells. © 2011 Mary Ann Liebert, Inc. Fil:Ladelfa, M.F. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Monte, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_15230864_v15_n6_p1749_Ladelfa
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	beta catenin hypoxia inducible factor mammalian target of rapamycin mitogen activated protein kinase phosphatidylinositol 3 kinase protein kinase B protein p53 reactive oxygen metabolite Smad protein stress activated protein kinase transforming growth factor beta Wnt protein apoptosis cell proliferation human hypoxia metabolic regulation nonhuman priority journal protein function review signal transduction Apoptosis Genomic Instability Humans Hypoxia-Inducible Factor 1, alpha Subunit Mitogen-Activated Protein Kinases Neoplasms Oncogenes Reactive Oxygen Species Signal Transduction TOR Serine-Threonine Kinases Transforming Growth Factor beta Tumor Suppressor Protein p53 Wnt Proteins
spellingShingle	beta catenin hypoxia inducible factor mammalian target of rapamycin mitogen activated protein kinase phosphatidylinositol 3 kinase protein kinase B protein p53 reactive oxygen metabolite Smad protein stress activated protein kinase transforming growth factor beta Wnt protein apoptosis cell proliferation human hypoxia metabolic regulation nonhuman priority journal protein function review signal transduction Apoptosis Genomic Instability Humans Hypoxia-Inducible Factor 1, alpha Subunit Mitogen-Activated Protein Kinases Neoplasms Oncogenes Reactive Oxygen Species Signal Transduction TOR Serine-Threonine Kinases Transforming Growth Factor beta Tumor Suppressor Protein p53 Wnt Proteins Ladelfa, M.F. Toledo, M.F. Laiseca, J.E. Monte, M. Interaction of p53 with tumor suppressive and oncogenic signaling pathways to control cellular reactive oxygen species production
topic_facet	beta catenin hypoxia inducible factor mammalian target of rapamycin mitogen activated protein kinase phosphatidylinositol 3 kinase protein kinase B protein p53 reactive oxygen metabolite Smad protein stress activated protein kinase transforming growth factor beta Wnt protein apoptosis cell proliferation human hypoxia metabolic regulation nonhuman priority journal protein function review signal transduction Apoptosis Genomic Instability Humans Hypoxia-Inducible Factor 1, alpha Subunit Mitogen-Activated Protein Kinases Neoplasms Oncogenes Reactive Oxygen Species Signal Transduction TOR Serine-Threonine Kinases Transforming Growth Factor beta Tumor Suppressor Protein p53 Wnt Proteins
description	p53 is a crucial transcription factor with tumor suppressive properties that elicits its function through specific target genes. It constitutes a pivotal system that integrates information received by many signaling pathways and subsequently orchestrates cell fate decisions, namely, growth-arrest, senescence, or apoptosis. Reactive oxygen species (ROS) production in cells can play a key role in signal transduction, being able to trigger different processes as cell death or cell proliferation. Sustained oxidative stress can induce genomic instability and collaborates with cancer development, whereas acute enhancement of high ROS levels leads to toxic oxidative cell damage and cell death. Here, it has been considered p53 broad potential contribution through its ability to regulate selected key cancer signaling pathways, where ROS participate as inductors or effectors of the final biological outcome. Further, we have discussed how p53 could play a role in preventing potentially harmful oxidative state and cell proliferation by pro-oncogenic pathways such as PI3K/AKT/mTOR and WNT/β-catenin or under hypoxia state. In addition, we have considered potential mechanisms by which p53 could collaborate with signal transduction pathways such as transforming growth factor-β (TGF-β) and stress-activated protein kinases (SAPK) that produce ROS, to stop or eliminate uncontrolled proliferating cells. © 2011 Mary Ann Liebert, Inc.
format	JOUR
author	Ladelfa, M.F. Toledo, M.F. Laiseca, J.E. Monte, M.
author_facet	Ladelfa, M.F. Toledo, M.F. Laiseca, J.E. Monte, M.
author_sort	Ladelfa, M.F.
title	Interaction of p53 with tumor suppressive and oncogenic signaling pathways to control cellular reactive oxygen species production
title_short	Interaction of p53 with tumor suppressive and oncogenic signaling pathways to control cellular reactive oxygen species production
title_full	Interaction of p53 with tumor suppressive and oncogenic signaling pathways to control cellular reactive oxygen species production
title_fullStr	Interaction of p53 with tumor suppressive and oncogenic signaling pathways to control cellular reactive oxygen species production
title_full_unstemmed	Interaction of p53 with tumor suppressive and oncogenic signaling pathways to control cellular reactive oxygen species production
title_sort	interaction of p53 with tumor suppressive and oncogenic signaling pathways to control cellular reactive oxygen species production
url	http://hdl.handle.net/20.500.12110/paper_15230864_v15_n6_p1749_Ladelfa
work_keys_str_mv	AT ladelfamf interactionofp53withtumorsuppressiveandoncogenicsignalingpathwaystocontrolcellularreactiveoxygenspeciesproduction AT toledomf interactionofp53withtumorsuppressiveandoncogenicsignalingpathwaystocontrolcellularreactiveoxygenspeciesproduction AT laisecaje interactionofp53withtumorsuppressiveandoncogenicsignalingpathwaystocontrolcellularreactiveoxygenspeciesproduction AT montem interactionofp53withtumorsuppressiveandoncogenicsignalingpathwaystocontrolcellularreactiveoxygenspeciesproduction
_version_	1807318625080573952

Interaction of p53 with tumor suppressive and oncogenic signaling pathways to control cellular reactive oxygen species production

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