INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions

The cyclin D-Cdk4-6/INK4/Rb/E2F pathway plays a key role in controlling cell growth by integrating multiple mitogenic and antimitogenic stimuli. The members of INK4 family, comprising p16INK4a, p15INK4b, p18INK4c, and p19INK4d, block the progression of the cell cycle by binding to either Cdk4 or Cdk...

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Detalles Bibliográficos
Autores principales:	Cánepa, E.T., Scassa, M.E., Ceruti, J.M., Marazita, M.C., Carcagno, A.L., Sirkin, P.F., Ogara, M.F.
Formato:	JOUR
Materias:	Apoptosis Cancer Cell cycle DNA repair INK4 Senescence ankyrin cyclin D cyclin dependent kinase 4 cyclin dependent kinase 6 cyclin dependent kinase inhibitor 2B cyclin dependent kinase inhibitor 2C cyclin dependent kinase inhibitor 2D protein p16INK4a scleroprotein transcription factor E2F1 apoptosis carcinogenesis cell cycle arrest cell cycle G1 phase cell cycle regulation cell growth cell lineage genetic variability human mitogenesis nonhuman protein binding protein expression protein function protein structure review senescence tissue specificity tumor suppressor gene Animals Cell Aging Cell Transformation, Neoplastic Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinase Inhibitor Proteins DNA Repair Humans Multigene Family Mammalia
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_15216543_v59_n7_p419_Canepa
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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