INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions

The cyclin D-Cdk4-6/INK4/Rb/E2F pathway plays a key role in controlling cell growth by integrating multiple mitogenic and antimitogenic stimuli. The members of INK4 family, comprising p16INK4a, p15INK4b, p18INK4c, and p19INK4d, block the progression of the cell cycle by binding to either Cdk4 or Cdk...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Cánepa, E.T., Scassa, M.E., Ceruti, J.M., Marazita, M.C., Carcagno, A.L., Sirkin, P.F., Ogara, M.F.
Formato:	JOUR
Materias:	Apoptosis Cancer Cell cycle DNA repair INK4 Senescence ankyrin cyclin D cyclin dependent kinase 4 cyclin dependent kinase 6 cyclin dependent kinase inhibitor 2B cyclin dependent kinase inhibitor 2C cyclin dependent kinase inhibitor 2D protein p16INK4a scleroprotein transcription factor E2F1 apoptosis carcinogenesis cell cycle arrest cell cycle G1 phase cell cycle regulation cell growth cell lineage genetic variability human mitogenesis nonhuman protein binding protein expression protein function protein structure review senescence tissue specificity tumor suppressor gene Animals Cell Aging Cell Transformation, Neoplastic Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinase Inhibitor Proteins DNA Repair Humans Multigene Family Mammalia
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_15216543_v59_n7_p419_Canepa
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	todo:paper_15216543_v59_n7_p419_Canepa
record_format	dspace
spelling	todo:paper_15216543_v59_n7_p419_Canepa2023-10-03T16:20:37Z INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions Cánepa, E.T. Scassa, M.E. Ceruti, J.M. Marazita, M.C. Carcagno, A.L. Sirkin, P.F. Ogara, M.F. Apoptosis Cancer Cell cycle DNA repair INK4 Senescence ankyrin cyclin D cyclin dependent kinase 4 cyclin dependent kinase 6 cyclin dependent kinase inhibitor 2B cyclin dependent kinase inhibitor 2C cyclin dependent kinase inhibitor 2D protein p16INK4a scleroprotein transcription factor E2F1 apoptosis carcinogenesis cell cycle arrest cell cycle G1 phase cell cycle regulation cell growth cell lineage DNA repair genetic variability human mitogenesis nonhuman protein binding protein expression protein function protein structure review senescence tissue specificity tumor suppressor gene Animals Apoptosis Cell Aging Cell Transformation, Neoplastic Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinase Inhibitor Proteins DNA Repair Humans Multigene Family Mammalia The cyclin D-Cdk4-6/INK4/Rb/E2F pathway plays a key role in controlling cell growth by integrating multiple mitogenic and antimitogenic stimuli. The members of INK4 family, comprising p16INK4a, p15INK4b, p18INK4c, and p19INK4d, block the progression of the cell cycle by binding to either Cdk4 or Cdk6 and inhibiting the action of cyclin D. These INK4 proteins share a similar structure dominated by several ankyrin repeats. Although they appear to be structurally redundant and equally potent as inhibitors, the INK4 family members are differentially expressed during mouse development. The striking diversity in the pattern of expression of INK4 genes suggested that this family of cell cycle inhibitors might have cell lineage-specific or tissue-specific functions. The INK4 proteins are commonly lost or inactivated by mutations in diverse types of cancer, and they represent established or candidate tumor suppressors. Apart from their capacity to arrest cells in the G1-phase of the cell cycle they have been shown to participate in an increasing number of cellular processes. Given their emerging roles in fundamental physiological as well as pathological processes, it is interesting to explore the diverse roles for the individual INK4 family members in different functions other than cell cycle regulation. Extensive studies, over the past few years, uncover the involvement of INK4 proteins in senescence, apoptosis, DNA repair, and multistep oncogenesis. We will focus the discussion here on these unexpected issues. © 2007 IUBMB. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_15216543_v59_n7_p419_Canepa
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Apoptosis Cancer Cell cycle DNA repair INK4 Senescence ankyrin cyclin D cyclin dependent kinase 4 cyclin dependent kinase 6 cyclin dependent kinase inhibitor 2B cyclin dependent kinase inhibitor 2C cyclin dependent kinase inhibitor 2D protein p16INK4a scleroprotein transcription factor E2F1 apoptosis carcinogenesis cell cycle arrest cell cycle G1 phase cell cycle regulation cell growth cell lineage DNA repair genetic variability human mitogenesis nonhuman protein binding protein expression protein function protein structure review senescence tissue specificity tumor suppressor gene Animals Apoptosis Cell Aging Cell Transformation, Neoplastic Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinase Inhibitor Proteins DNA Repair Humans Multigene Family Mammalia
spellingShingle	Apoptosis Cancer Cell cycle DNA repair INK4 Senescence ankyrin cyclin D cyclin dependent kinase 4 cyclin dependent kinase 6 cyclin dependent kinase inhibitor 2B cyclin dependent kinase inhibitor 2C cyclin dependent kinase inhibitor 2D protein p16INK4a scleroprotein transcription factor E2F1 apoptosis carcinogenesis cell cycle arrest cell cycle G1 phase cell cycle regulation cell growth cell lineage DNA repair genetic variability human mitogenesis nonhuman protein binding protein expression protein function protein structure review senescence tissue specificity tumor suppressor gene Animals Apoptosis Cell Aging Cell Transformation, Neoplastic Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinase Inhibitor Proteins DNA Repair Humans Multigene Family Mammalia Cánepa, E.T. Scassa, M.E. Ceruti, J.M. Marazita, M.C. Carcagno, A.L. Sirkin, P.F. Ogara, M.F. INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions
topic_facet	Apoptosis Cancer Cell cycle DNA repair INK4 Senescence ankyrin cyclin D cyclin dependent kinase 4 cyclin dependent kinase 6 cyclin dependent kinase inhibitor 2B cyclin dependent kinase inhibitor 2C cyclin dependent kinase inhibitor 2D protein p16INK4a scleroprotein transcription factor E2F1 apoptosis carcinogenesis cell cycle arrest cell cycle G1 phase cell cycle regulation cell growth cell lineage DNA repair genetic variability human mitogenesis nonhuman protein binding protein expression protein function protein structure review senescence tissue specificity tumor suppressor gene Animals Apoptosis Cell Aging Cell Transformation, Neoplastic Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinase Inhibitor Proteins DNA Repair Humans Multigene Family Mammalia
description	The cyclin D-Cdk4-6/INK4/Rb/E2F pathway plays a key role in controlling cell growth by integrating multiple mitogenic and antimitogenic stimuli. The members of INK4 family, comprising p16INK4a, p15INK4b, p18INK4c, and p19INK4d, block the progression of the cell cycle by binding to either Cdk4 or Cdk6 and inhibiting the action of cyclin D. These INK4 proteins share a similar structure dominated by several ankyrin repeats. Although they appear to be structurally redundant and equally potent as inhibitors, the INK4 family members are differentially expressed during mouse development. The striking diversity in the pattern of expression of INK4 genes suggested that this family of cell cycle inhibitors might have cell lineage-specific or tissue-specific functions. The INK4 proteins are commonly lost or inactivated by mutations in diverse types of cancer, and they represent established or candidate tumor suppressors. Apart from their capacity to arrest cells in the G1-phase of the cell cycle they have been shown to participate in an increasing number of cellular processes. Given their emerging roles in fundamental physiological as well as pathological processes, it is interesting to explore the diverse roles for the individual INK4 family members in different functions other than cell cycle regulation. Extensive studies, over the past few years, uncover the involvement of INK4 proteins in senescence, apoptosis, DNA repair, and multistep oncogenesis. We will focus the discussion here on these unexpected issues. © 2007 IUBMB.
format	JOUR
author	Cánepa, E.T. Scassa, M.E. Ceruti, J.M. Marazita, M.C. Carcagno, A.L. Sirkin, P.F. Ogara, M.F.
author_facet	Cánepa, E.T. Scassa, M.E. Ceruti, J.M. Marazita, M.C. Carcagno, A.L. Sirkin, P.F. Ogara, M.F.
author_sort	Cánepa, E.T.
title	INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions
title_short	INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions
title_full	INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions
title_fullStr	INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions
title_full_unstemmed	INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions
title_sort	ink4 proteins, a family of mammalian cdk inhibitors with novel biological functions
url	http://hdl.handle.net/20.500.12110/paper_15216543_v59_n7_p419_Canepa
work_keys_str_mv	AT canepaet ink4proteinsafamilyofmammaliancdkinhibitorswithnovelbiologicalfunctions AT scassame ink4proteinsafamilyofmammaliancdkinhibitorswithnovelbiologicalfunctions AT cerutijm ink4proteinsafamilyofmammaliancdkinhibitorswithnovelbiologicalfunctions AT marazitamc ink4proteinsafamilyofmammaliancdkinhibitorswithnovelbiologicalfunctions AT carcagnoal ink4proteinsafamilyofmammaliancdkinhibitorswithnovelbiologicalfunctions AT sirkinpf ink4proteinsafamilyofmammaliancdkinhibitorswithnovelbiologicalfunctions AT ogaramf ink4proteinsafamilyofmammaliancdkinhibitorswithnovelbiologicalfunctions
_version_	1807319392013254656

INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions

Ejemplares similares