Confocal raman spectroscopy: Determination of natural moisturizing factor profile related to skin hydration

Introduction: Skin health and skin care to reduce the effects of aging are the main interests of many researchers. The skin is very important because it protects the body from various effects of the external environment, and studies of the largest organ of the human body have been conducted since an...

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Autores principales: Teixeira, A.P., Rangel, J.L., Raniero, L.J., Tosato, M.G., Fávero, P.P., Martin, A.A.
Formato: JOUR
Materias:
Confocal Raman spectroscopy
Cosmetics
NMF
Skin aging
Skin
Biochemical composition
External environments
Noninvasive technique
Stratum corneum
Superficial layers
Hydration
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_15173151_v30_n1_p11_Teixeira
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id todo:paper_15173151_v30_n1_p11_Teixeira
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spelling todo:paper_15173151_v30_n1_p11_Teixeira2023-10-03T16:19:50Z Confocal raman spectroscopy: Determination of natural moisturizing factor profile related to skin hydration Teixeira, A.P. Rangel, J.L. Raniero, L.J. Tosato, M.G. Fávero, P.P. Martin, A.A. Confocal Raman spectroscopy Cosmetics NMF Skin aging Cosmetics Skin Biochemical composition Confocal Raman spectroscopy External environments NMF Noninvasive technique Skin aging Stratum corneum Superficial layers Hydration Introduction: Skin health and skin care to reduce the effects of aging are the main interests of many researchers. The skin is very important because it protects the body from various effects of the external environment, and studies of the largest organ of the human body have been conducted since antiquity. In skin, aging effects are severe enough to promote changes in cell structure and biochemical composition. In this study, we quantitatively analyzed the water content and natural moisturizing factor of human facial skin in vivo and in real time by confocal Raman spectroscopy. This non-invasive technique is capable of providing detailed information on the biochemical composition at different depth profiles in the skin. Methods: We studied 10 volunteers, phototype II (40 and 50 years old), using a confocal Raman system to examine the skin surface down to 25 μm. Raman spectra were obtained before product use (T0), and after 30 days of continuous use of cosmetics (T30). Results: The results show a significant increase of 6.4% in water content in the surface layer of the facial skin after the cosmetic use. The amounts of natural moisturizing factor (NMF) compounds were also increased. Urocanic acid underwent a greater change in relation to carboxylic acid pyrrolidone, with a 38.5% increase in the stratum corneum. Conclusion: Confocal Raman spectroscopy identified changes in the biochemical composition of the superficial layers of the epidermis, which suggests the anti-aging efficacy of the formulation. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_15173151_v30_n1_p11_Teixeira
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Confocal Raman spectroscopy
Cosmetics
NMF
Skin aging
Cosmetics
Skin
Biochemical composition
Confocal Raman spectroscopy
External environments
NMF
Noninvasive technique
Skin aging
Stratum corneum
Superficial layers
Hydration
spellingShingle Confocal Raman spectroscopy
Cosmetics
NMF
Skin aging
Cosmetics
Skin
Biochemical composition
Confocal Raman spectroscopy
External environments
NMF
Noninvasive technique
Skin aging
Stratum corneum
Superficial layers
Hydration
Teixeira, A.P.
Rangel, J.L.
Raniero, L.J.
Tosato, M.G.
Fávero, P.P.
Martin, A.A.
Confocal raman spectroscopy: Determination of natural moisturizing factor profile related to skin hydration
topic_facet Confocal Raman spectroscopy
Cosmetics
NMF
Skin aging
Cosmetics
Skin
Biochemical composition
Confocal Raman spectroscopy
External environments
NMF
Noninvasive technique
Skin aging
Stratum corneum
Superficial layers
Hydration
description Introduction: Skin health and skin care to reduce the effects of aging are the main interests of many researchers. The skin is very important because it protects the body from various effects of the external environment, and studies of the largest organ of the human body have been conducted since antiquity. In skin, aging effects are severe enough to promote changes in cell structure and biochemical composition. In this study, we quantitatively analyzed the water content and natural moisturizing factor of human facial skin in vivo and in real time by confocal Raman spectroscopy. This non-invasive technique is capable of providing detailed information on the biochemical composition at different depth profiles in the skin. Methods: We studied 10 volunteers, phototype II (40 and 50 years old), using a confocal Raman system to examine the skin surface down to 25 μm. Raman spectra were obtained before product use (T0), and after 30 days of continuous use of cosmetics (T30). Results: The results show a significant increase of 6.4% in water content in the surface layer of the facial skin after the cosmetic use. The amounts of natural moisturizing factor (NMF) compounds were also increased. Urocanic acid underwent a greater change in relation to carboxylic acid pyrrolidone, with a 38.5% increase in the stratum corneum. Conclusion: Confocal Raman spectroscopy identified changes in the biochemical composition of the superficial layers of the epidermis, which suggests the anti-aging efficacy of the formulation.
format JOUR
author Teixeira, A.P.
Rangel, J.L.
Raniero, L.J.
Tosato, M.G.
Fávero, P.P.
Martin, A.A.
author_facet Teixeira, A.P.
Rangel, J.L.
Raniero, L.J.
Tosato, M.G.
Fávero, P.P.
Martin, A.A.
author_sort Teixeira, A.P.
title Confocal raman spectroscopy: Determination of natural moisturizing factor profile related to skin hydration
title_short Confocal raman spectroscopy: Determination of natural moisturizing factor profile related to skin hydration
title_full Confocal raman spectroscopy: Determination of natural moisturizing factor profile related to skin hydration
title_fullStr Confocal raman spectroscopy: Determination of natural moisturizing factor profile related to skin hydration
title_full_unstemmed Confocal raman spectroscopy: Determination of natural moisturizing factor profile related to skin hydration
title_sort confocal raman spectroscopy: determination of natural moisturizing factor profile related to skin hydration
url http://hdl.handle.net/20.500.12110/paper_15173151_v30_n1_p11_Teixeira
work_keys_str_mv AT teixeiraap confocalramanspectroscopydeterminationofnaturalmoisturizingfactorprofilerelatedtoskinhydration
AT rangeljl confocalramanspectroscopydeterminationofnaturalmoisturizingfactorprofilerelatedtoskinhydration
AT ranierolj confocalramanspectroscopydeterminationofnaturalmoisturizingfactorprofilerelatedtoskinhydration
AT tosatomg confocalramanspectroscopydeterminationofnaturalmoisturizingfactorprofilerelatedtoskinhydration
AT faveropp confocalramanspectroscopydeterminationofnaturalmoisturizingfactorprofilerelatedtoskinhydration
AT martinaa confocalramanspectroscopydeterminationofnaturalmoisturizingfactorprofilerelatedtoskinhydration
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