17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior
Weight loss is an effective intervention for diminishing disease burden in obese older adults. Pharmacological interventions that reduce food intake and thereby promote weight loss may offer effective strategies to reduce age-related disease. We previously reported that 17α-estradiol (17α-E2) admini...
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todo:paper_14749718_v17_n1_p_Steyn2023-10-03T16:18:37Z 17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior Steyn, F.J. Ngo, S.T. Chen, V.P. Bailey-Downs, L.C. Xie, T.Y. Ghadami, M. Brimijoin, S. Freeman, W.M. Rubinstein, M. Low, M.J. Stout, M.B. 17α-estradiol aging food intake hypothalamus obesity pro-opiomelanocortin 17alpha estradiol glucose insulin proopiomelanocortin animal experiment appetite arcuate nucleus Article body mass caloric intake controlled study feeding behavior food intake gene gene expression genetic transcription glucose blood level homeostasis hypothalamus insulin blood level male metabolic balance mouse nonhuman obesity Pomc gene priority journal protein expression satiety Weight loss is an effective intervention for diminishing disease burden in obese older adults. Pharmacological interventions that reduce food intake and thereby promote weight loss may offer effective strategies to reduce age-related disease. We previously reported that 17α-estradiol (17α-E2) administration elicits beneficial effects on metabolism and inflammation in old male mice. These observations were associated with reduced calorie intake. Here, we demonstrate that 17α-E2 acts through pro-opiomelanocortin (Pomc) expression in the arcuate nucleus (ARC) to reduce food intake and body mass in mouse models of obesity. These results confirm that 17α-E2 modulates appetite through selective interactions within hypothalamic anorexigenic pathways. Interestingly, some peripheral markers of metabolic homeostasis were also improved in animals with near complete loss of ARC Pomc transcription. This suggests that 17α-E2 might have central and peripheral actions that can beneficially affect metabolism cooperatively or independently. © 2017 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_14749718_v17_n1_p_Steyn |
| institution |
Universidad de Buenos Aires |
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I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
17α-estradiol aging food intake hypothalamus obesity pro-opiomelanocortin 17alpha estradiol glucose insulin proopiomelanocortin animal experiment appetite arcuate nucleus Article body mass caloric intake controlled study feeding behavior food intake gene gene expression genetic transcription glucose blood level homeostasis hypothalamus insulin blood level male metabolic balance mouse nonhuman obesity Pomc gene priority journal protein expression satiety |
| spellingShingle |
17α-estradiol aging food intake hypothalamus obesity pro-opiomelanocortin 17alpha estradiol glucose insulin proopiomelanocortin animal experiment appetite arcuate nucleus Article body mass caloric intake controlled study feeding behavior food intake gene gene expression genetic transcription glucose blood level homeostasis hypothalamus insulin blood level male metabolic balance mouse nonhuman obesity Pomc gene priority journal protein expression satiety Steyn, F.J. Ngo, S.T. Chen, V.P. Bailey-Downs, L.C. Xie, T.Y. Ghadami, M. Brimijoin, S. Freeman, W.M. Rubinstein, M. Low, M.J. Stout, M.B. 17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior |
| topic_facet |
17α-estradiol aging food intake hypothalamus obesity pro-opiomelanocortin 17alpha estradiol glucose insulin proopiomelanocortin animal experiment appetite arcuate nucleus Article body mass caloric intake controlled study feeding behavior food intake gene gene expression genetic transcription glucose blood level homeostasis hypothalamus insulin blood level male metabolic balance mouse nonhuman obesity Pomc gene priority journal protein expression satiety |
| description |
Weight loss is an effective intervention for diminishing disease burden in obese older adults. Pharmacological interventions that reduce food intake and thereby promote weight loss may offer effective strategies to reduce age-related disease. We previously reported that 17α-estradiol (17α-E2) administration elicits beneficial effects on metabolism and inflammation in old male mice. These observations were associated with reduced calorie intake. Here, we demonstrate that 17α-E2 acts through pro-opiomelanocortin (Pomc) expression in the arcuate nucleus (ARC) to reduce food intake and body mass in mouse models of obesity. These results confirm that 17α-E2 modulates appetite through selective interactions within hypothalamic anorexigenic pathways. Interestingly, some peripheral markers of metabolic homeostasis were also improved in animals with near complete loss of ARC Pomc transcription. This suggests that 17α-E2 might have central and peripheral actions that can beneficially affect metabolism cooperatively or independently. © 2017 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. |
| format |
JOUR |
| author |
Steyn, F.J. Ngo, S.T. Chen, V.P. Bailey-Downs, L.C. Xie, T.Y. Ghadami, M. Brimijoin, S. Freeman, W.M. Rubinstein, M. Low, M.J. Stout, M.B. |
| author_facet |
Steyn, F.J. Ngo, S.T. Chen, V.P. Bailey-Downs, L.C. Xie, T.Y. Ghadami, M. Brimijoin, S. Freeman, W.M. Rubinstein, M. Low, M.J. Stout, M.B. |
| author_sort |
Steyn, F.J. |
| title |
17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior |
| title_short |
17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior |
| title_full |
17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior |
| title_fullStr |
17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior |
| title_full_unstemmed |
17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior |
| title_sort |
17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior |
| url |
http://hdl.handle.net/20.500.12110/paper_14749718_v17_n1_p_Steyn |
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