A comparative study of the photophysical and phototoxic properties of octakis(decyloxy)phthalocyaninato zinc(II), incorporated in a hydrophilic polymer, in liposomes and in non-ionic micelles
Factors such as charge, aggregation and lipophilicity influence photosensitiser localisation. The lipophilic octasubstituted sensitiser 2,3,9,10,16,17,23,24-octakis(decyloxy)phthalocyaninato zinc(II) was incorporated into liposomes of dimyristoyl-L-α-phosphatidylcholine (DMPC), non-ionic micelles of...
Guardado en:
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | JOUR |
| Materias: | |
| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_1474905X_v2_n10_p988_Rodriguez |
| Aporte de: |
| id |
todo:paper_1474905X_v2_n10_p988_Rodriguez |
|---|---|
| record_format |
dspace |
| spelling |
todo:paper_1474905X_v2_n10_p988_Rodriguez2023-10-03T16:18:24Z A comparative study of the photophysical and phototoxic properties of octakis(decyloxy)phthalocyaninato zinc(II), incorporated in a hydrophilic polymer, in liposomes and in non-ionic micelles Rodriguez, M.E. Morán, F. Bonansea, A. Monetti, M. Fernández, D.A. Strassert, C.A. Rivarola, V. Awruch, J. Dicelio, L.E. 2,3,9,10,16,17,23,24 octakis(decyloxy)phthalocyaninato zinc dimyristoylphosphatidylcholine liposome photosensitizing agent polymer polysorbate 80 singlet oxygen solutol hs 15 unclassified drug zinc derivative dimyristoylphosphatidylcholine liposome organometallic compound photosensitizing agent polymer apoptosis article cell death cell viability controlled study drug mechanism drug structure HEp 2 cell human human cell irradiation lipophilicity micelle photodynamic therapy phototoxicity priority journal biology cell line cell survival chemistry comparative study drug effect necrosis photochemistry photochemotherapy Apoptosis Cell Line Cell Survival Dimyristoylphosphatidylcholine Humans Liposomes Micelles Necrosis Organometallic Compounds Photobiology Photochemistry Photochemotherapy Photosensitizing Agents Polymers Factors such as charge, aggregation and lipophilicity influence photosensitiser localisation. The lipophilic octasubstituted sensitiser 2,3,9,10,16,17,23,24-octakis(decyloxy)phthalocyaninato zinc(II) was incorporated into liposomes of dimyristoyl-L-α-phosphatidylcholine (DMPC), non-ionic micelles of Tween 80 and the hydrosoluble polymer Solutol® HS 15 in order to investigate how these different environments affect the photophysical properties and phototoxicity of the photosensitiser. Fluorescence quantum yields and singlet molecular oxygen generation are enhanced in the presence of Solutol® HS 15. Phototoxicities were calculated by employing a concentration of 10-7 M of the dye against the Hcp-2 cell line, which showed a viability of 53 and 30% in DMPC and Solutol® HS 15, respectively. After 24 h of photodynamic therapy with 15 min irradiation, apoptotic and necrotic cells were observed. © The Royal Society of Chemistry and Owner Societies 2003. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_1474905X_v2_n10_p988_Rodriguez |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
2,3,9,10,16,17,23,24 octakis(decyloxy)phthalocyaninato zinc dimyristoylphosphatidylcholine liposome photosensitizing agent polymer polysorbate 80 singlet oxygen solutol hs 15 unclassified drug zinc derivative dimyristoylphosphatidylcholine liposome organometallic compound photosensitizing agent polymer apoptosis article cell death cell viability controlled study drug mechanism drug structure HEp 2 cell human human cell irradiation lipophilicity micelle photodynamic therapy phototoxicity priority journal biology cell line cell survival chemistry comparative study drug effect necrosis photochemistry photochemotherapy Apoptosis Cell Line Cell Survival Dimyristoylphosphatidylcholine Humans Liposomes Micelles Necrosis Organometallic Compounds Photobiology Photochemistry Photochemotherapy Photosensitizing Agents Polymers |
| spellingShingle |
2,3,9,10,16,17,23,24 octakis(decyloxy)phthalocyaninato zinc dimyristoylphosphatidylcholine liposome photosensitizing agent polymer polysorbate 80 singlet oxygen solutol hs 15 unclassified drug zinc derivative dimyristoylphosphatidylcholine liposome organometallic compound photosensitizing agent polymer apoptosis article cell death cell viability controlled study drug mechanism drug structure HEp 2 cell human human cell irradiation lipophilicity micelle photodynamic therapy phototoxicity priority journal biology cell line cell survival chemistry comparative study drug effect necrosis photochemistry photochemotherapy Apoptosis Cell Line Cell Survival Dimyristoylphosphatidylcholine Humans Liposomes Micelles Necrosis Organometallic Compounds Photobiology Photochemistry Photochemotherapy Photosensitizing Agents Polymers Rodriguez, M.E. Morán, F. Bonansea, A. Monetti, M. Fernández, D.A. Strassert, C.A. Rivarola, V. Awruch, J. Dicelio, L.E. A comparative study of the photophysical and phototoxic properties of octakis(decyloxy)phthalocyaninato zinc(II), incorporated in a hydrophilic polymer, in liposomes and in non-ionic micelles |
| topic_facet |
2,3,9,10,16,17,23,24 octakis(decyloxy)phthalocyaninato zinc dimyristoylphosphatidylcholine liposome photosensitizing agent polymer polysorbate 80 singlet oxygen solutol hs 15 unclassified drug zinc derivative dimyristoylphosphatidylcholine liposome organometallic compound photosensitizing agent polymer apoptosis article cell death cell viability controlled study drug mechanism drug structure HEp 2 cell human human cell irradiation lipophilicity micelle photodynamic therapy phototoxicity priority journal biology cell line cell survival chemistry comparative study drug effect necrosis photochemistry photochemotherapy Apoptosis Cell Line Cell Survival Dimyristoylphosphatidylcholine Humans Liposomes Micelles Necrosis Organometallic Compounds Photobiology Photochemistry Photochemotherapy Photosensitizing Agents Polymers |
| description |
Factors such as charge, aggregation and lipophilicity influence photosensitiser localisation. The lipophilic octasubstituted sensitiser 2,3,9,10,16,17,23,24-octakis(decyloxy)phthalocyaninato zinc(II) was incorporated into liposomes of dimyristoyl-L-α-phosphatidylcholine (DMPC), non-ionic micelles of Tween 80 and the hydrosoluble polymer Solutol® HS 15 in order to investigate how these different environments affect the photophysical properties and phototoxicity of the photosensitiser. Fluorescence quantum yields and singlet molecular oxygen generation are enhanced in the presence of Solutol® HS 15. Phototoxicities were calculated by employing a concentration of 10-7 M of the dye against the Hcp-2 cell line, which showed a viability of 53 and 30% in DMPC and Solutol® HS 15, respectively. After 24 h of photodynamic therapy with 15 min irradiation, apoptotic and necrotic cells were observed. © The Royal Society of Chemistry and Owner Societies 2003. |
| format |
JOUR |
| author |
Rodriguez, M.E. Morán, F. Bonansea, A. Monetti, M. Fernández, D.A. Strassert, C.A. Rivarola, V. Awruch, J. Dicelio, L.E. |
| author_facet |
Rodriguez, M.E. Morán, F. Bonansea, A. Monetti, M. Fernández, D.A. Strassert, C.A. Rivarola, V. Awruch, J. Dicelio, L.E. |
| author_sort |
Rodriguez, M.E. |
| title |
A comparative study of the photophysical and phototoxic properties of octakis(decyloxy)phthalocyaninato zinc(II), incorporated in a hydrophilic polymer, in liposomes and in non-ionic micelles |
| title_short |
A comparative study of the photophysical and phototoxic properties of octakis(decyloxy)phthalocyaninato zinc(II), incorporated in a hydrophilic polymer, in liposomes and in non-ionic micelles |
| title_full |
A comparative study of the photophysical and phototoxic properties of octakis(decyloxy)phthalocyaninato zinc(II), incorporated in a hydrophilic polymer, in liposomes and in non-ionic micelles |
| title_fullStr |
A comparative study of the photophysical and phototoxic properties of octakis(decyloxy)phthalocyaninato zinc(II), incorporated in a hydrophilic polymer, in liposomes and in non-ionic micelles |
| title_full_unstemmed |
A comparative study of the photophysical and phototoxic properties of octakis(decyloxy)phthalocyaninato zinc(II), incorporated in a hydrophilic polymer, in liposomes and in non-ionic micelles |
| title_sort |
comparative study of the photophysical and phototoxic properties of octakis(decyloxy)phthalocyaninato zinc(ii), incorporated in a hydrophilic polymer, in liposomes and in non-ionic micelles |
| url |
http://hdl.handle.net/20.500.12110/paper_1474905X_v2_n10_p988_Rodriguez |
| work_keys_str_mv |
AT rodriguezme acomparativestudyofthephotophysicalandphototoxicpropertiesofoctakisdecyloxyphthalocyaninatozinciiincorporatedinahydrophilicpolymerinliposomesandinnonionicmicelles AT moranf acomparativestudyofthephotophysicalandphototoxicpropertiesofoctakisdecyloxyphthalocyaninatozinciiincorporatedinahydrophilicpolymerinliposomesandinnonionicmicelles AT bonanseaa acomparativestudyofthephotophysicalandphototoxicpropertiesofoctakisdecyloxyphthalocyaninatozinciiincorporatedinahydrophilicpolymerinliposomesandinnonionicmicelles AT monettim acomparativestudyofthephotophysicalandphototoxicpropertiesofoctakisdecyloxyphthalocyaninatozinciiincorporatedinahydrophilicpolymerinliposomesandinnonionicmicelles AT fernandezda acomparativestudyofthephotophysicalandphototoxicpropertiesofoctakisdecyloxyphthalocyaninatozinciiincorporatedinahydrophilicpolymerinliposomesandinnonionicmicelles AT strassertca acomparativestudyofthephotophysicalandphototoxicpropertiesofoctakisdecyloxyphthalocyaninatozinciiincorporatedinahydrophilicpolymerinliposomesandinnonionicmicelles AT rivarolav acomparativestudyofthephotophysicalandphototoxicpropertiesofoctakisdecyloxyphthalocyaninatozinciiincorporatedinahydrophilicpolymerinliposomesandinnonionicmicelles AT awruchj acomparativestudyofthephotophysicalandphototoxicpropertiesofoctakisdecyloxyphthalocyaninatozinciiincorporatedinahydrophilicpolymerinliposomesandinnonionicmicelles AT diceliole acomparativestudyofthephotophysicalandphototoxicpropertiesofoctakisdecyloxyphthalocyaninatozinciiincorporatedinahydrophilicpolymerinliposomesandinnonionicmicelles AT rodriguezme comparativestudyofthephotophysicalandphototoxicpropertiesofoctakisdecyloxyphthalocyaninatozinciiincorporatedinahydrophilicpolymerinliposomesandinnonionicmicelles AT moranf comparativestudyofthephotophysicalandphototoxicpropertiesofoctakisdecyloxyphthalocyaninatozinciiincorporatedinahydrophilicpolymerinliposomesandinnonionicmicelles AT bonanseaa comparativestudyofthephotophysicalandphototoxicpropertiesofoctakisdecyloxyphthalocyaninatozinciiincorporatedinahydrophilicpolymerinliposomesandinnonionicmicelles AT monettim comparativestudyofthephotophysicalandphototoxicpropertiesofoctakisdecyloxyphthalocyaninatozinciiincorporatedinahydrophilicpolymerinliposomesandinnonionicmicelles AT fernandezda comparativestudyofthephotophysicalandphototoxicpropertiesofoctakisdecyloxyphthalocyaninatozinciiincorporatedinahydrophilicpolymerinliposomesandinnonionicmicelles AT strassertca comparativestudyofthephotophysicalandphototoxicpropertiesofoctakisdecyloxyphthalocyaninatozinciiincorporatedinahydrophilicpolymerinliposomesandinnonionicmicelles AT rivarolav comparativestudyofthephotophysicalandphototoxicpropertiesofoctakisdecyloxyphthalocyaninatozinciiincorporatedinahydrophilicpolymerinliposomesandinnonionicmicelles AT awruchj comparativestudyofthephotophysicalandphototoxicpropertiesofoctakisdecyloxyphthalocyaninatozinciiincorporatedinahydrophilicpolymerinliposomesandinnonionicmicelles AT diceliole comparativestudyofthephotophysicalandphototoxicpropertiesofoctakisdecyloxyphthalocyaninatozinciiincorporatedinahydrophilicpolymerinliposomesandinnonionicmicelles |
| _version_ |
1807314613648228352 |