Emerging roles of ATF2 and the dynamic AP1 network in cancer

Cooperation among transcription factors is central for their ability to execute specific transcriptional programmes. The AP1 complex exemplifies a network of transcription factors that function in unison under normal circumstances and during the course of tumour development and progression. This Per...

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Detalles Bibliográficos
Autores principales: Lopez-Bergami, P., Lau, E., Ronai, Z.
Formato: JOUR
Materias:
activating transcription factor 2
activating transcription factor 3
activating transcription factor 4
cathepsin L
cyclic AMP responsive element binding protein
cyclin A
ezrin
gelatinase A
gelatinase B
high mobility group B1 protein
interstitial collagenase
mitogen activated protein kinase kinase 4
protein fos
stathmin
stromelysin
transcription factor AP 1
transcription factor FosB
transcription factor Fra 1
transcription factor JunB
transcription factor JunD
vasculotropin A
angiogenesis
apoptosis
cancer invasion
carcinogenesis
cell cycle regulation
cell differentiation
cell survival
human
in vitro study
in vivo study
metastasis
nonhuman
priority journal
protein degradation
protein expression
protein phosphorylation
protein structure
review
signal transduction
stem cell
Activating Transcription Factor 2
Animals
Gene Regulatory Networks
Humans
Multigene Family
Neoplasms
Protein Binding
Proto-Oncogene Proteins c-jun
Transcription Factor AP-1
Acceso en línea:http://hdl.handle.net/20.500.12110/paper_1474175X_v10_n1_p65_LopezBergami
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Cooperation among transcription factors is central for their ability to execute specific transcriptional programmes. The AP1 complex exemplifies a network of transcription factors that function in unison under normal circumstances and during the course of tumour development and progression. This Perspective summarizes our current understanding of the changes in members of the AP1 complex and the role of ATF2 as part of this complex in tumorigenesis.

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