Emerging roles of ATF2 and the dynamic AP1 network in cancer
Cooperation among transcription factors is central for their ability to execute specific transcriptional programmes. The AP1 complex exemplifies a network of transcription factors that function in unison under normal circumstances and during the course of tumour development and progression. This Per...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_1474175X_v10_n1_p65_LopezBergami |
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todo:paper_1474175X_v10_n1_p65_LopezBergami2023-10-03T16:18:12Z Emerging roles of ATF2 and the dynamic AP1 network in cancer Lopez-Bergami, P. Lau, E. Ronai, Z. activating transcription factor 2 activating transcription factor 3 activating transcription factor 4 cathepsin L cyclic AMP responsive element binding protein cyclin A ezrin gelatinase A gelatinase B high mobility group B1 protein interstitial collagenase mitogen activated protein kinase kinase 4 protein fos stathmin stromelysin transcription factor AP 1 transcription factor FosB transcription factor Fra 1 transcription factor JunB transcription factor JunD vasculotropin A angiogenesis apoptosis cancer invasion carcinogenesis cell cycle regulation cell differentiation cell survival human in vitro study in vivo study metastasis nonhuman priority journal protein degradation protein expression protein phosphorylation protein structure review signal transduction stem cell Activating Transcription Factor 2 Animals Gene Regulatory Networks Humans Multigene Family Neoplasms Protein Binding Proto-Oncogene Proteins c-jun Transcription Factor AP-1 Cooperation among transcription factors is central for their ability to execute specific transcriptional programmes. The AP1 complex exemplifies a network of transcription factors that function in unison under normal circumstances and during the course of tumour development and progression. This Perspective summarizes our current understanding of the changes in members of the AP1 complex and the role of ATF2 as part of this complex in tumorigenesis. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_1474175X_v10_n1_p65_LopezBergami |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
activating transcription factor 2 activating transcription factor 3 activating transcription factor 4 cathepsin L cyclic AMP responsive element binding protein cyclin A ezrin gelatinase A gelatinase B high mobility group B1 protein interstitial collagenase mitogen activated protein kinase kinase 4 protein fos stathmin stromelysin transcription factor AP 1 transcription factor FosB transcription factor Fra 1 transcription factor JunB transcription factor JunD vasculotropin A angiogenesis apoptosis cancer invasion carcinogenesis cell cycle regulation cell differentiation cell survival human in vitro study in vivo study metastasis nonhuman priority journal protein degradation protein expression protein phosphorylation protein structure review signal transduction stem cell Activating Transcription Factor 2 Animals Gene Regulatory Networks Humans Multigene Family Neoplasms Protein Binding Proto-Oncogene Proteins c-jun Transcription Factor AP-1 |
| spellingShingle |
activating transcription factor 2 activating transcription factor 3 activating transcription factor 4 cathepsin L cyclic AMP responsive element binding protein cyclin A ezrin gelatinase A gelatinase B high mobility group B1 protein interstitial collagenase mitogen activated protein kinase kinase 4 protein fos stathmin stromelysin transcription factor AP 1 transcription factor FosB transcription factor Fra 1 transcription factor JunB transcription factor JunD vasculotropin A angiogenesis apoptosis cancer invasion carcinogenesis cell cycle regulation cell differentiation cell survival human in vitro study in vivo study metastasis nonhuman priority journal protein degradation protein expression protein phosphorylation protein structure review signal transduction stem cell Activating Transcription Factor 2 Animals Gene Regulatory Networks Humans Multigene Family Neoplasms Protein Binding Proto-Oncogene Proteins c-jun Transcription Factor AP-1 Lopez-Bergami, P. Lau, E. Ronai, Z. Emerging roles of ATF2 and the dynamic AP1 network in cancer |
| topic_facet |
activating transcription factor 2 activating transcription factor 3 activating transcription factor 4 cathepsin L cyclic AMP responsive element binding protein cyclin A ezrin gelatinase A gelatinase B high mobility group B1 protein interstitial collagenase mitogen activated protein kinase kinase 4 protein fos stathmin stromelysin transcription factor AP 1 transcription factor FosB transcription factor Fra 1 transcription factor JunB transcription factor JunD vasculotropin A angiogenesis apoptosis cancer invasion carcinogenesis cell cycle regulation cell differentiation cell survival human in vitro study in vivo study metastasis nonhuman priority journal protein degradation protein expression protein phosphorylation protein structure review signal transduction stem cell Activating Transcription Factor 2 Animals Gene Regulatory Networks Humans Multigene Family Neoplasms Protein Binding Proto-Oncogene Proteins c-jun Transcription Factor AP-1 |
| description |
Cooperation among transcription factors is central for their ability to execute specific transcriptional programmes. The AP1 complex exemplifies a network of transcription factors that function in unison under normal circumstances and during the course of tumour development and progression. This Perspective summarizes our current understanding of the changes in members of the AP1 complex and the role of ATF2 as part of this complex in tumorigenesis. |
| format |
JOUR |
| author |
Lopez-Bergami, P. Lau, E. Ronai, Z. |
| author_facet |
Lopez-Bergami, P. Lau, E. Ronai, Z. |
| author_sort |
Lopez-Bergami, P. |
| title |
Emerging roles of ATF2 and the dynamic AP1 network in cancer |
| title_short |
Emerging roles of ATF2 and the dynamic AP1 network in cancer |
| title_full |
Emerging roles of ATF2 and the dynamic AP1 network in cancer |
| title_fullStr |
Emerging roles of ATF2 and the dynamic AP1 network in cancer |
| title_full_unstemmed |
Emerging roles of ATF2 and the dynamic AP1 network in cancer |
| title_sort |
emerging roles of atf2 and the dynamic ap1 network in cancer |
| url |
http://hdl.handle.net/20.500.12110/paper_1474175X_v10_n1_p65_LopezBergami |
| work_keys_str_mv |
AT lopezbergamip emergingrolesofatf2andthedynamicap1networkincancer AT laue emergingrolesofatf2andthedynamicap1networkincancer AT ronaiz emergingrolesofatf2andthedynamicap1networkincancer |
| _version_ |
1807321496630067200 |