Turning 'sweet' on immunity: Galectin-glycan interactions in immune tolerance and inflammation
The function of deciphering the biological information encoded by the glycome, which is the entire repertoire of complex sugar structures expressed by cells and tissues, is assigned in part to endogenous glycan-binding proteins or lectins. Galectins, a family of animal lectins that bind N-acetyllact...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_14741733_v9_n5_p338_Rabinovich |
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todo:paper_14741733_v9_n5_p338_Rabinovich2023-10-03T16:18:12Z Turning 'sweet' on immunity: Galectin-glycan interactions in immune tolerance and inflammation Rabinovich, G.A. Toscano, M.A. ecalectin galectin galectin 1 galectin 10 galectin 11 galectin 12 galectin 13 galectin 15 galectin 2 galectin 3 galectin 5 galectin 6 galectin 7 galectin 8 glycan glycoprotein interleukin 6 lectin toll like receptor unclassified drug adaptive immunity allergy autoimmune disease autoimmunity cell survival chronic inflammation cytokine release dendritic cell homeostasis host pathogen interaction human immune response immunity immunocompetent cell immunological tolerance immunoregulation lymphocyte function nonhuman priority journal protein interaction protein structure regulatory T lymphocyte review T lymphocyte T lymphocyte activation Animals Disease Galectins Homeostasis Humans Immune Tolerance Inflammation Polysaccharides The function of deciphering the biological information encoded by the glycome, which is the entire repertoire of complex sugar structures expressed by cells and tissues, is assigned in part to endogenous glycan-binding proteins or lectins. Galectins, a family of animal lectins that bind N-acetyllactosamine- containing glycans, have many roles in diverse immune cell processes, including those relevant to pathogen recognition, shaping the course of adaptive immune responses and fine-tuning the inflammatory response. How do galectins translate glycan-encoded information into tolerogenic or inflammatory cell programmes? An improved understanding of the mechanisms underlying these functions will provide further opportunities for developing new therapies based on the immunoregulatory properties of this multifaceted protein family. © 2009 Macmillan Publishers Limited. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_14741733_v9_n5_p338_Rabinovich |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
ecalectin galectin galectin 1 galectin 10 galectin 11 galectin 12 galectin 13 galectin 15 galectin 2 galectin 3 galectin 5 galectin 6 galectin 7 galectin 8 glycan glycoprotein interleukin 6 lectin toll like receptor unclassified drug adaptive immunity allergy autoimmune disease autoimmunity cell survival chronic inflammation cytokine release dendritic cell homeostasis host pathogen interaction human immune response immunity immunocompetent cell immunological tolerance immunoregulation lymphocyte function nonhuman priority journal protein interaction protein structure regulatory T lymphocyte review T lymphocyte T lymphocyte activation Animals Disease Galectins Homeostasis Humans Immune Tolerance Inflammation Polysaccharides |
| spellingShingle |
ecalectin galectin galectin 1 galectin 10 galectin 11 galectin 12 galectin 13 galectin 15 galectin 2 galectin 3 galectin 5 galectin 6 galectin 7 galectin 8 glycan glycoprotein interleukin 6 lectin toll like receptor unclassified drug adaptive immunity allergy autoimmune disease autoimmunity cell survival chronic inflammation cytokine release dendritic cell homeostasis host pathogen interaction human immune response immunity immunocompetent cell immunological tolerance immunoregulation lymphocyte function nonhuman priority journal protein interaction protein structure regulatory T lymphocyte review T lymphocyte T lymphocyte activation Animals Disease Galectins Homeostasis Humans Immune Tolerance Inflammation Polysaccharides Rabinovich, G.A. Toscano, M.A. Turning 'sweet' on immunity: Galectin-glycan interactions in immune tolerance and inflammation |
| topic_facet |
ecalectin galectin galectin 1 galectin 10 galectin 11 galectin 12 galectin 13 galectin 15 galectin 2 galectin 3 galectin 5 galectin 6 galectin 7 galectin 8 glycan glycoprotein interleukin 6 lectin toll like receptor unclassified drug adaptive immunity allergy autoimmune disease autoimmunity cell survival chronic inflammation cytokine release dendritic cell homeostasis host pathogen interaction human immune response immunity immunocompetent cell immunological tolerance immunoregulation lymphocyte function nonhuman priority journal protein interaction protein structure regulatory T lymphocyte review T lymphocyte T lymphocyte activation Animals Disease Galectins Homeostasis Humans Immune Tolerance Inflammation Polysaccharides |
| description |
The function of deciphering the biological information encoded by the glycome, which is the entire repertoire of complex sugar structures expressed by cells and tissues, is assigned in part to endogenous glycan-binding proteins or lectins. Galectins, a family of animal lectins that bind N-acetyllactosamine- containing glycans, have many roles in diverse immune cell processes, including those relevant to pathogen recognition, shaping the course of adaptive immune responses and fine-tuning the inflammatory response. How do galectins translate glycan-encoded information into tolerogenic or inflammatory cell programmes? An improved understanding of the mechanisms underlying these functions will provide further opportunities for developing new therapies based on the immunoregulatory properties of this multifaceted protein family. © 2009 Macmillan Publishers Limited. |
| format |
JOUR |
| author |
Rabinovich, G.A. Toscano, M.A. |
| author_facet |
Rabinovich, G.A. Toscano, M.A. |
| author_sort |
Rabinovich, G.A. |
| title |
Turning 'sweet' on immunity: Galectin-glycan interactions in immune tolerance and inflammation |
| title_short |
Turning 'sweet' on immunity: Galectin-glycan interactions in immune tolerance and inflammation |
| title_full |
Turning 'sweet' on immunity: Galectin-glycan interactions in immune tolerance and inflammation |
| title_fullStr |
Turning 'sweet' on immunity: Galectin-glycan interactions in immune tolerance and inflammation |
| title_full_unstemmed |
Turning 'sweet' on immunity: Galectin-glycan interactions in immune tolerance and inflammation |
| title_sort |
turning 'sweet' on immunity: galectin-glycan interactions in immune tolerance and inflammation |
| url |
http://hdl.handle.net/20.500.12110/paper_14741733_v9_n5_p338_Rabinovich |
| work_keys_str_mv |
AT rabinovichga turningsweetonimmunitygalectinglycaninteractionsinimmunetoleranceandinflammation AT toscanoma turningsweetonimmunitygalectinglycaninteractionsinimmunetoleranceandinflammation |
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