Synthesis and biological evaluation of glutathione-like tripeptidesagainstTrypanosoma cruzi

Glutathionylspermidine synthase (GSS) is a crucial enzyme in the trypanothione biosynthetic pathway and is also an interesting molecular target for drug design. We synthesized a series of amides of a glutathione analogue (L-γ-Glu-L-Leu-Gly-NHR) where R are linear alkyl groups. All of these drugs exh...

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Detalles Bibliográficos
Autores principales:	Ravaschino, E.L., Docampo, R., Rodriguez, J.B.
Formato:	JOUR
Materias:	American trypanosomiasis Glutathionylspermidine synthase Trypanosoma cruzi Trypanothione gamma glutamyl alpha benzyl ester leucylgylcyl n 1 butylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 heptylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 hexylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 octylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 pentylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 propylamide gamma glutamyl alpha benzyl ester leucylgylcyl n ethylamide gamma glutamyl alpha benzyl ester leucylgylcyl n methylamide glutathione derivative glutathionylspermidine synthase n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 butylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 heptylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 hexylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 octylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 pentylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 propylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n ethylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n methylamide spermidine synthase tripeptide derivative unclassified drug article Chagas disease drug screening drug structure nonhuman peptide synthesis
Acceso en línea:	http://hdl.handle.net/20.500.12110/paper_14246376_v2003_n10_p298_Ravaschino
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

Descripción
Sumario:	Glutathionylspermidine synthase (GSS) is a crucial enzyme in the trypanothione biosynthetic pathway and is also an interesting molecular target for drug design. We synthesized a series of amides of a glutathione analogue (L-γ-Glu-L-Leu-Gly-NHR) where R are linear alkyl groups. All of these drugs exhibited marginal biological activity against the responsible agent of Chagas' disease, the protozoan Trypanosoma cruzi.

Synthesis and biological evaluation of glutathione-like tripeptidesagainstTrypanosoma cruzi

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