Synthesis and biological evaluation of glutathione-like tripeptidesagainstTrypanosoma cruzi
Glutathionylspermidine synthase (GSS) is a crucial enzyme in the trypanothione biosynthetic pathway and is also an interesting molecular target for drug design. We synthesized a series of amides of a glutathione analogue (L-γ-Glu-L-Leu-Gly-NHR) where R are linear alkyl groups. All of these drugs exh...
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| Acceso en línea: | http://hdl.handle.net/20.500.12110/paper_14246376_v2003_n10_p298_Ravaschino |
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todo:paper_14246376_v2003_n10_p298_Ravaschino2023-10-03T16:13:37Z Synthesis and biological evaluation of glutathione-like tripeptidesagainstTrypanosoma cruzi Ravaschino, E.L. Docampo, R. Rodriguez, J.B. American trypanosomiasis Glutathionylspermidine synthase Trypanosoma cruzi Trypanothione gamma glutamyl alpha benzyl ester leucylgylcyl n 1 butylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 heptylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 hexylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 octylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 pentylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 propylamide gamma glutamyl alpha benzyl ester leucylgylcyl n ethylamide gamma glutamyl alpha benzyl ester leucylgylcyl n methylamide glutathione derivative glutathionylspermidine synthase n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 butylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 heptylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 hexylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 octylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 pentylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 propylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n ethylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n methylamide spermidine synthase tripeptide derivative unclassified drug article Chagas disease drug screening drug structure nonhuman peptide synthesis Trypanosoma cruzi Glutathionylspermidine synthase (GSS) is a crucial enzyme in the trypanothione biosynthetic pathway and is also an interesting molecular target for drug design. We synthesized a series of amides of a glutathione analogue (L-γ-Glu-L-Leu-Gly-NHR) where R are linear alkyl groups. All of these drugs exhibited marginal biological activity against the responsible agent of Chagas' disease, the protozoan Trypanosoma cruzi. Fil:Ravaschino, E.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Rodriguez, J.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. JOUR info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar http://hdl.handle.net/20.500.12110/paper_14246376_v2003_n10_p298_Ravaschino |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
American trypanosomiasis Glutathionylspermidine synthase Trypanosoma cruzi Trypanothione gamma glutamyl alpha benzyl ester leucylgylcyl n 1 butylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 heptylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 hexylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 octylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 pentylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 propylamide gamma glutamyl alpha benzyl ester leucylgylcyl n ethylamide gamma glutamyl alpha benzyl ester leucylgylcyl n methylamide glutathione derivative glutathionylspermidine synthase n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 butylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 heptylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 hexylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 octylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 pentylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 propylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n ethylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n methylamide spermidine synthase tripeptide derivative unclassified drug article Chagas disease drug screening drug structure nonhuman peptide synthesis Trypanosoma cruzi |
| spellingShingle |
American trypanosomiasis Glutathionylspermidine synthase Trypanosoma cruzi Trypanothione gamma glutamyl alpha benzyl ester leucylgylcyl n 1 butylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 heptylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 hexylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 octylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 pentylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 propylamide gamma glutamyl alpha benzyl ester leucylgylcyl n ethylamide gamma glutamyl alpha benzyl ester leucylgylcyl n methylamide glutathione derivative glutathionylspermidine synthase n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 butylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 heptylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 hexylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 octylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 pentylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 propylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n ethylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n methylamide spermidine synthase tripeptide derivative unclassified drug article Chagas disease drug screening drug structure nonhuman peptide synthesis Trypanosoma cruzi Ravaschino, E.L. Docampo, R. Rodriguez, J.B. Synthesis and biological evaluation of glutathione-like tripeptidesagainstTrypanosoma cruzi |
| topic_facet |
American trypanosomiasis Glutathionylspermidine synthase Trypanosoma cruzi Trypanothione gamma glutamyl alpha benzyl ester leucylgylcyl n 1 butylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 heptylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 hexylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 octylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 pentylamide gamma glutamyl alpha benzyl ester leucylgylcyl n 1 propylamide gamma glutamyl alpha benzyl ester leucylgylcyl n ethylamide gamma glutamyl alpha benzyl ester leucylgylcyl n methylamide glutathione derivative glutathionylspermidine synthase n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 butylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 heptylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 hexylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 octylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 pentylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n 1 propylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n ethylamide n benzyloxycarbonyl gamma glutamyl alpha benzyl ester leucylgylcyl n methylamide spermidine synthase tripeptide derivative unclassified drug article Chagas disease drug screening drug structure nonhuman peptide synthesis Trypanosoma cruzi |
| description |
Glutathionylspermidine synthase (GSS) is a crucial enzyme in the trypanothione biosynthetic pathway and is also an interesting molecular target for drug design. We synthesized a series of amides of a glutathione analogue (L-γ-Glu-L-Leu-Gly-NHR) where R are linear alkyl groups. All of these drugs exhibited marginal biological activity against the responsible agent of Chagas' disease, the protozoan Trypanosoma cruzi. |
| format |
JOUR |
| author |
Ravaschino, E.L. Docampo, R. Rodriguez, J.B. |
| author_facet |
Ravaschino, E.L. Docampo, R. Rodriguez, J.B. |
| author_sort |
Ravaschino, E.L. |
| title |
Synthesis and biological evaluation of glutathione-like tripeptidesagainstTrypanosoma cruzi |
| title_short |
Synthesis and biological evaluation of glutathione-like tripeptidesagainstTrypanosoma cruzi |
| title_full |
Synthesis and biological evaluation of glutathione-like tripeptidesagainstTrypanosoma cruzi |
| title_fullStr |
Synthesis and biological evaluation of glutathione-like tripeptidesagainstTrypanosoma cruzi |
| title_full_unstemmed |
Synthesis and biological evaluation of glutathione-like tripeptidesagainstTrypanosoma cruzi |
| title_sort |
synthesis and biological evaluation of glutathione-like tripeptidesagainsttrypanosoma cruzi |
| url |
http://hdl.handle.net/20.500.12110/paper_14246376_v2003_n10_p298_Ravaschino |
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AT ravaschinoel synthesisandbiologicalevaluationofglutathioneliketripeptidesagainsttrypanosomacruzi AT docampor synthesisandbiologicalevaluationofglutathioneliketripeptidesagainsttrypanosomacruzi AT rodriguezjb synthesisandbiologicalevaluationofglutathioneliketripeptidesagainsttrypanosomacruzi |
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1807318342313181184 |